Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)

产生 NIDA 机会的群体合作联盟 (C3PNO)

• 批准号: 10352063
• 负责人: Pamina Mae Gorbach
• 金额: $ 40.09万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10352063
• 关键词: 2019-nCoV; AIDS prevention; Address; Adherence; Administrative Supplement; Affect; Appointment; Area; Attitude; Baltimore; Behavior; COVID-19; COVID-19 pandemic; COVID-19 testing; COVID-19 vaccination; California; Caring; Chicago; Collection; Communities; Competence; Consequentialism; Counseling; Data; Disease; Drug usage; Drug user; Ethnic Origin; Food; Frequencies; Funding; Funding Opportunities; HIV; HIV Infections; Health; Heart; Housing; Imprisonment; Individual; Infrastructure; Interruption; Link; Location; Los Angeles; Measures; Mediating; Medical; Medical Records; Mental Health; NIH Program Announcements; National Institute of Drug Abuse; Opioid; Outcome; Participant; Patient Self-Report; Pattern; Persons; Pharmaceutical Preparations; Population; Race; Recovery; Reporting; Research; Risk; Risk Factors; SARS-CoV-2 infection; Science; Severities; Smoking; Specific qualifier value; Structure; Substance Use Disorder; Surveys; Symptoms; Syndrome; Technology; Time; Tobacco; Universities; Vaccination; Vaccines; Vulnerable Populations; antiretroviral therapy; base; behavior test; cohort; data harmonization; design; experience; frontier; high risk; interest; intimate partner violence; marijuana vaping; novel; opioid use disorder; pandemic disease; pre-exposure prophylaxis; prescription opioid; protective behavior; public health emergency; response; social; stimulant use; substance use; substance use treatment; uptake; vaccine acceptance; vaccine hesitancy; vaping

ABSTRACT In response to the Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements and Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (Notice Number NOT-DA-20-047 and linked Program Announcement PA-18-591) funding opportunity, the Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO; U24DA044554) proposes to assess the impact of COVID-19 on the participating cohorts - including people who use drugs (PWUD), people living with HIV (PLWH), and those at high-risk for HIV infection. We propose to expand the C3PNO COVID-19 module developed under a previous supplement (4U24DA044554-03:S2) to include vaccination attitudes, uptake, and adherence as well as post- COVID-19 symptoms and syndrome. The new module will allow further longitudinal assessment of the practice of protective behaviors, testing, substance use, and mental health in the C3PNO cohorts for at least two more rounds six months apart resulting in two years of data related to COVID-19 pandemic experiences. This approach will allow us to longitudinally assess vaccination hesitancy/acceptability and structural factors' association with uptake and adherence to COVID-19 vaccination. Additionally, we will use our current infrastructure and C3PNO validated harmonization strategies to compile new and existing data across the cohorts in order to: assess changes in social and individual determinants of health during the course of the COVID-19 pandemic, to estimate differences in substance-using behaviors of those who were confirmed/probable cases of COVID-19 (based on self-report or medical record) and those who were not a confirmed/probable case, and to assess how PLWH and people who are at high risk for HIV in C3PNO have different experiences in and responses to the COVID-19 epidemic. The C3PNO Coordinating Center at The University of California, Los Angeles (UCLA) and Frontier Science will facilitate the design and implementation of a survey to collect data from a subset of participants from each of C3PNO cohorts (ACCESS, ALIVE, the Heart Study, HYM, JHHCC, MASH, mSTUDY, RADAR, and V- DUS). Cohorts will issue the survey to participants and transfer the resulting data to the coordinating center. If funded, this administrative supplement would allow a rapid and coordinated collection of linked COVID-19, HIV, and substance use data related to an ongoing public health emergency affecting the highly vulnerable substance- using populations followed by the cohorts. COVID-19 data harmonization with other HIV cohorts will further aide our collective effort to understand the impact of COVID-19 on these at risk communities. Finally, C3PNO's effort to assess changes in social and individual determinants of health, vaccine attitudes, differences in substance- using behavior, and the impact HIV-affected individuals during the course of the COVID-19 pandemic is both novel and critical in this time of unprecedented social upheaval and instability.

抽象的 响应有关行政补品可用性的特殊利益通知（NOSI）和 紧急竞争修订2019年小说冠状病毒（通知号非DA-DA-20-047）的竞争性修订 和链接的计划公告PA-18-591）资助机会，合作联盟 生产NIDA机会（C3PNO; U24DA044554）提议评估COVID-19的影响 参加人群 - 包括使用毒品的人（PWUD），艾滋病毒（PLWH）的人以及 高危HIV感染。我们建议扩大以前开发的C3pno covid-19模块 补充（4U24DA044554-03：S2）包括疫苗接种态度，摄取和依从性以及后 COVID-19症状和综合征。新模块将允许对实践进行进一步的纵向评估 C3PNO队列中至少两个的保护行为，测试，药物使用和心理健康 相距六个月，导致了与Covid-19-19的大流行经历有关的两年数据。这种方法 将使我们能够纵向评估疫苗接种犹豫/可接受性和结构性因素与与结构性因素的关联 吸收和遵守COVID-19疫苗接种。此外，我们将使用当前的基础架构和C3PNO 经过验证的协调策略，以跨同类群体编译新数据和现有数据，以评估 在19009年大流行期间，社会和个人决定因素的变化，以估计 被确认/可能的covid案例的人的物质行为差异（基于 自我报告或病历）以及没有确认/可能的情况的人，并评估PLWH和 在C3PNO中患HIV的高风险的人在Covid-19中有不同的经验和回应 流行性。加利福尼亚大学，洛杉矶大学（UCLA）和Frontier的C3PNO协调中心 科学将促进调查的设计和实施，以从参与者的一部分中收集数据 每个C3PNO队列（访问，活着，心脏研究，HYM，JHHCC，MASH，MASH，MSTUDY，RADAR和V-） dus）。同伙将向参与者发出调查，并将结果数据转移到协调中心。如果 资助，这种行政补充剂将允许快速，协调的链接covid-19，艾滋病毒，艾滋病毒， 与正在进行的公共卫生紧急情况有关的物质使用数据影响高度脆弱的物质 - 使用人群，然后使用队列。 COVID-19与其他HIV队列的数据协调将进一步助长 我们集体努力了解Covid-19对这些风险社区的影响。最后，C3PNO的努力 评估社会和个人决定因素的变化，疫苗态度，物质差异 - 使用行为，以及在COVID-19大流行期间受HIV影响的个体的影响都是 在这个前所未有的社会动荡和不稳定的时代，新颖而至关重要。