Targeted Protein Degradation: From Small Molecules to Complex Organelles

靶向蛋白质降解：从小分子到复杂细胞器

基本信息

批准号：
10237082
负责人：
Thale Cross Jarvis
金额：
$ 1.68万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10237082
关键词：
Academia Age Area Attention Austria Automobile Driving Autophagocytosis Basic Science Cell physiology Collaborations Complex Degradation Pathway Disease Educational workshop Exposure to Fostering Functional disorder Future Generations Goals Health Homeostasis Industrialization Industry Knowledge Maintenance Malignant Neoplasms Martens Methodology Methods Molecular Molecular Chaperones Nerve Degeneration Organelles Outcome Pathology Pathway interactions Peptide Hydrolases Physiological Play Positioning Attribute Process Proteins Proteome Research Research Personnel Role Scientist Shapes Signal Transduction Speed System Techniques Therapeutic Translations Ubiquitin Vision career clinical implementation clinical practice gender diversity insight multicatalytic endopeptidase complex novel posters programs protein degradation small molecule small molecule therapeutics symposium technological innovation

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Targeted Protein Degradation: From Small Molecules to Complex Organelles, organized by Drs. Sascha Martens, Tim Clausen and Judith Frydman. The conference will be held in Vienna, Austria from June 6-9, 2021. Targeted protein degradation plays a critical role in regulating nearly all cellular functions, and as such, its dysfunction is associated with severe pathologies including diseases like cancer, neurodegeneration and age- associated diseases. Therefore, fundamental insights into protein clearance pathways might be harnessed for therapeutic applications against a wide range of diseases. While much progress has been made in revealing mechanisms of autophagy and the ubiquitin-proteasome system, the major protein degradation pathways defined thus far, these fields continue to remain isolated from each other despite the interconnection of these processes. This separation is now leading to an urgent need to discuss the interplay of these pathways at the molecular and cellular levels to integrate our understanding of these processes and how they contribute to disease pathology. This conference will bring together researchers from these different fields, who do not typically interact, to build a holistic and integrated vision of protein degradation. Such an integrative conference highlighting the connections between the different branches of protein degradation research does not yet exist, so this Keystone Symposia conference will be the first of its kind to reshape how these fields interact and collaborate to yield transformative insights into both basic science and disease processes. Topics of discussion will include: (1) Substrate recognition and processing by energy-dependent proteases, autophagy and lysosomal pathways; (2) Signals targeting proteins to distinct degradation pathways; (3) Interplay between proteolytic systems and chaperone pathways; (4) Reprogramming degradation with small molecules for therapeutic applications; (5) Degradation programs driving global proteome remodeling. Attendees will be exposed to novel perspectives, as well as methods, techniques and approaches, that will advance research within their field, and across the many different components in the protein degradation landscape.

抽象的请求支持题为“靶向蛋白质降解：从小到大”的 Keystone Symposia 会议分子到复杂细胞器，由 Drs 组织。萨莎·马滕斯、蒂姆·克劳森和朱迪思·弗里德曼。这会议将于2021年6月6日至9日在奥地利维也纳举行。靶向蛋白质降解在调节几乎所有细胞功能中发挥着关键作用，因此，其功能障碍与严重的病理有关，包括癌症、神经退行性疾病和年龄相关的疾病。相关疾病。因此，可以利用对蛋白质清除途径的基本见解针对多种疾病的治疗应用。虽然在揭示方面已经取得了很大进展自噬和泛素蛋白酶体系统的机制，主要的蛋白质降解途径迄今为止的定义，尽管这些领域相互关联，但它们仍然彼此隔离。流程。这种分离现在导致迫切需要讨论这些途径的相互作用。分子和细胞水平整合我们对这些过程及其如何贡献的理解疾病病理学。这次会议将汇集来自这些不同领域的研究人员，他们不通常相互作用，以建立蛋白质降解的整体和综合愿景。这样的综合性会议强调了蛋白质降解研究不同分支之间的联系尚不存在，因此本次 Keystone 研讨会将是第一次重塑这些领域的此类会议互动和协作，以产生对基础科学和疾病过程的变革性见解。主题讨论内容包括：（1）能量依赖性蛋白酶的底物识别和加工、自噬和溶酶体途径； (2) 将蛋白质靶向不同降解途径的信号； (3) 之间的相互作用蛋白水解系统和伴侣途径； (4) 用小分子重编程降解治疗应用； (5) 驱动全球蛋白质组重塑的降解计划。参加者将是接触新的观点以及方法、技术和途径，这将推动研究在他们的领域内，以及蛋白质降解领域的许多不同组成部分。