2nd Biennial ASBMB - BSC Symposium on the Interplay between Epigenetic Regulation and Genome Integrity

第二届两年一度的 ASBMB - BSC 表观遗传调控与基因组完整性之间相互作用研讨会

• 批准号: 10540502
• 负责人: Jessica K Tyler
• 金额: $ 0.96万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540502
• 关键词: Academia; Aging; Ally; American; Area; Attention; Back; Biochemistry; Biological; Biophysics; COVID-19 pandemic; Cell Aging; Cells; Cellular biology; Chemoprevention; China; Chromatin; Chromatin Disassembly; Chromatin Structure; Clinical; Collaborations; Communities; Country; DNA; DNA Repair; DNA biosynthesis; DNA lesion; Development; Dietary Intervention; Disease; Drug Targeting; Eating; Enzymes; Epigenetic Process; Female; Fertilization; Fostering; Genetic Transcription; Genome; Genome Stability; Genomic Instability; Genomics; Goals; Growth; Health; Higher Order Chromatin Structure; Histones; Human; Industrialization; Industry; International; Investigation; Joints; Knowledge; Link; Location; Malignant - descriptor; Malignant Neoplasms; Mediating; Medical; Mentors; Metabolic Diseases; Molecular; Molecular Biology; Molecular Chaperones; Molecular Mechanisms of Action; Movement; Oral; Participant; Persons; Pharmacology; Play; Post-Translational Protein Processing; Premature aging syndrome; Prize; Process; Proteins; Public Health; Regulation; Replication Initiation; Research; Research Personnel; Role; Scientist; Series; Societies; Structure; Talents; Technology; Therapeutic; Therapeutic Intervention; Time; Underrepresented Minority; Work; age related; base; career; career development; chromatin modification; chromatin remodeling; epigenetic regulation; epigenome; genome integrity; histone modification; human disease; insight; interest; meetings; new technology; novel therapeutic intervention; novel therapeutics; posters; prevent; recruit; repaired; response; symposium

Abstract Over the past few years, it has become increasingly important to understand how epigenetics and chromatin states impact DNA replication and DNA repair, two key processes critical for maintaining genome integrity. However, most meetings on epigenetics and chromatin focus on transcription, while most meetings on DNA repair or DNA replication include little attention to epigenetics and chromatin. The major focus of this meeting will be the dynamic interplay among chromatin, including histone modifications and high-order chromatin structure, and processes related to genome integrity, including DNA replication, DNA repair and the damage response and is the only meeting dedicated to this subject. Moreover, the meeting also highlights how the interplay between epigenetics and genome stability goes awry in cancer and aging cells. Therefore, this conference will bridge this gap to link researchers who are interested in epigenetic regulations and chromatin with those who are interested in genome integrity. The goal of this conference is to bring together scientists who are interested in epigenetic regulation and genome integrity together for discussion and interactions. A primary objective is to transfer knowledge and foster collaboration between basic academic researchers, clinical scientists, and industrial researchers to understand how epigenetic states regulate genome stability and vice versa, and how this goes awry in a diverse set of cancers and age-related diseases. In addition to the scientific focus, we will promote interactions between two societies, the American Society for Biochemistry and Molecular Biology (ASBMB) and the Biophysical Society of China (BSC). A second objective is to foster the development and interests of younger investigators to help support their career development. The participants stay and eat at the meeting venue, so they have ample time for informal brainstorming and networking. While we have two outstanding keynote speakers and other field leaders that have already committed to speak, most of the talks will be chosen from the submitted abstracts, enabling junior scientists to be highlighted in talks. Further, the meeting will provide an opportunity for poster prize winners to give a short presentation, which is important for their career development. We will also have a panel discussion on professional development and career options, aimed to provide further support for the young investigators. Moreover, there will be a diversity networking session, and multiple meet the speaker sessions that will be highlighted at the meeting. This meeting is particularly timely because of the linkage between epigenetics therapeutics, genome stability and cancer. The first joint conference of the two societies, ASBMB and BSC, was held in Suzhou, China in 2019 and was very successful attended by 275 scientists from all around the world, and we look forward to holding the conference in Seattle, WA, USA on Sept 28-Oct 2nd in 2022.

抽象的 在过去的几年中，了解表观遗传学和染色质是越来越重要的 状态会影响DNA复制和DNA修复，这对于维持基因组完整性至关重要的两个关键过程。 但是，大多数有关表观遗传学和染色质的会议都集中在转录上，而大多数会议上的DNA会议 修复或DNA复制很少关注表观遗传学和染色质。这次会议的主要重点 将是染色质之间的动态相互作用，包括组蛋白修饰和高阶染色质 结构和与基因组完整性有关的过程，包括DNA复制，DNA修复和损伤 回应，是唯一致力于此主题的会议。此外，会议还强调了 表观遗传学和基因组稳定性之间的相互作用在癌症和衰老细胞中出现问题。因此，这个 会议将弥合这一差距，以联系对表观遗传法规和染色质感兴趣的研究人员 与那些对基因组完整性感兴趣的人在一起。这次会议的目的是将科学家汇集在一起 对表观遗传调节和基因组完整性感兴趣的人一起讨论和相互作用。一个 主要目标是转移知识并促进基础学术研究人员之间的合作 临床科学家和工业研究人员了解表观遗传状态如何调节基因组稳定性和 反之亦然，以及在多种癌症和与年龄有关的疾病中的出现。除了 科学重点，我们将促进两个社会之间的互动，美国生物化学学会和 分子生物学（ASBMB）和中国生物物理学会（BSC）。第二个目标是促进 年轻调查人员的发展和利益，以帮助他们的职业发展。参与者 在会议场所留下来，因此他们有足够的时间进行非正式的集思广益和网络。尽管 我们有两个出色的主题演讲者和其他已经承诺发言的现场领导者，大多数 会谈将从提交的摘要中选择，使初级科学家能够在谈判中强调。 此外，会议将为海报获奖者提供简短介绍的机会，这是 对他们的职业发展很重要。我们还将进行有关专业发展和 职业选择，旨在为年轻的调查人员提供进一步的支持。而且，将会有多样性 网络会议，多个会议会议会议将在会议上强调的演讲者会议。这 会议特别及时，因为表观遗传学治疗剂，基因组稳定和 癌症。这两个社会的第一次联席会议ASBMB和BSC于2019年在中国苏州举行 来自世界各地的275名科学家参加了非常成功的参加，我们期待着 2022年9月28日在美国华盛顿州西雅图举行的会议。