FASEB Summer Conference on Transcriptional Regulation During Cell Growth

FASEB 细胞生长过程转录调控夏季会议

• 批准号: 7484009
• 负责人: Jessica K Tyler
• 金额: $ 1.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7484009
• 关键词: Academy; Area; Back; Biological; Biological Models; Cell Differentiation process; Cells; Chromatin; Collaborations; Colorado; Complex; DNA; Development; Developmental Biology; Disabled Persons; Disease; End Point; Epigenetic Process; Fertilization; Fibroblasts; Fostering; Funding; Gene Expression Regulation; Genes; Genetic Transcription; Genome; Goals; Growth and Development function; Health; Human; Knowledge; Location; Malignant Neoplasms; Maps; Minority; Modification; Molecular; Pathway interactions; Philosophy; Pluripotent Stem Cells; Problem Solving; Process; Purpose; Range; Recording of previous events; Regulatory Pathway; Research Personnel; Scientist; Signal Transduction; Site; Students; System; Transcription factor genes; Transcriptional Regulation; Travel; Tumor Suppressor Genes; Vermont; Woman; Work; base; cell growth; day; human disease; new technology; oncology; programs; scientific organization; symposium; transcription factor

DESCRIPTION (provided by applicant): Partial funding is requested for a five day FASEB conference on "Transcriptional Regulation During Cell Growth, Differentiation, and Development" to be held at Snowmass Village, Colorado in June 2008. The ability to globally analyze transcription factor pathways and chromatin modification has revolutionized the fields of signal transduction, developmental biology and oncology. An emerging theme is that epigenetic modifications of chromatin and DNA accompany all aspects of gene regulation. This is also the case during the gene misregulation that leads to human diseases including cancer. Yet many fundamental questions remain as to how covalent modifications of chromatin impact the assembly and disassembly of the transcriptional machinery in different contexts. An understanding of the specific mechanisms is central to determining, for example, how tumor suppressor genes are epigenetically inactivated in some cancers and how can a fibroblast be reprogrammed to generate a pluripotent stem cell? The purpose of this conference is to foster new transcriptional approaches to solving problems like these. We have assembled an outstanding group of established, midlevel and newly minted scientists that are at the cutting-edge, examining disparate issues ranging from fundamental mechanisms of transcription to deciphering global networks of interacting genes and transcription factors during development. This FASEB meeting is unique within these fields because it brings together scientists who employ vastly different approaches to study transcriptional regulation. The key objective of the conference will be to leverage the diversity of approaches and systems to generate a new paradigm for studying transcription in complex biological systems. Our philosophy is that knowledge of basic mechanisms provides an important perspective for understanding how networks of genes are activated and silenced during development, differentiation and disease, including cancer. As transcription is the ultimate endpoint for many regulatory processes an understanding of its mechanism will have profound implications for human health.

描述（由申请人提供）：要求为 2008 年 6 月在科罗拉多州斯诺马斯村举行的为期五天的 FASEB 会议提供部分资金，会议主题为“细胞生长、分化和发育过程中的转录调控”。 全球分析转录因子通路的能力染色质修饰彻底改变了信号转导、发育生物学和肿瘤学领域。一个新兴的主题是染色质和 DNA 的表观遗传修饰伴随着基因调控的各个方面。基因失调导致包括癌症在内的人类疾病也是如此。然而，关于染色质的共价修饰如何影响不同环境下转录机制的组装和分解，仍然存在许多基本问题。了解具体机制对于确定肿瘤抑制基因如何在某些癌症中表观遗传失活以及成纤维细胞如何重新编程以产生多能干细胞等至关重要。这次会议的目的是培育新的转录方法来解决此类问题。我们聚集了一支由资深、中层和新晋科学家组成的杰出团队，他们处于前沿，研究不同的问题，从转录的基本机制到破译发育过程中相互作用的基因和转录因子的全球网络。这次 FASEB 会议在这些领域中是独一无二的，因为它汇集了采用截然不同的方法来研究转录调控的科学家。会议的主要目标是利用方法和系统的多样性来生成研究复杂生物系统中转录的新范式。我们的理念是，对基本机制的了解为理解基因网络在发育、分化和疾病（包括癌症）过程中如何激活和沉默提供了重要视角。由于转录是许多调控过程的最终终点，对其机制的理解将对人类健康产生深远的影响。