FASEB's The Reversible Protein Acetylation in Health and Disease Conference

FASEB 健康与疾病中的可逆蛋白质乙酰化会议

基本信息

批准号：
10230422
负责人：
Jessica K Tyler
金额：
$ 0.8万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10230422
关键词：
Acetylation Acetyltransferase Aging Ally American Antineoplastic Agents Architecture Area Basic Science Binding Binding Proteins Biochemistry Biological Biology Bromodomain Cancer Etiology Carbon Cations Cell Cycle Progression Cell Proliferation Cells Cellular biology Charge Chemicals Chemoprevention Clinical Clinical Research Collaborations Communities Country DNA Repair DNA biosynthesis Deacetylase Development Dietary Intervention Disease Docking Drug Targeting Eating Enzyme Interaction Enzymes Etiology European FDA approved Faculty Female Fertilization Fostering Gene Expression Genetic Genetic Transcription Genome Genome Stability Germany Goals Growth Growth and Development function Health Histone Deacetylase Histone Deacetylase Inhibitor Homeostasis Human Immune response Industrialization Industry International Investigation Italy Knowledge Link London Longevity Lysine Malignant Neoplasms Medical Mentors Metabolic Diseases Metabolism Methylation Mitochondria Modification Molecular Molecular Biology Molecular Mechanisms of Action Montana N-terminal New Agents Nuclear Oral Participant Pathway interactions Patients Pattern Pharmacology Phosphorylation Play Portugal Post-Translational Protein Processing Premature aging syndrome Prize Process Protein Acetylation Protein Secretion Proteins Public Health Puerto Rico Reader Regulation Reporting Research Research Personnel Resort Role Scientist Side Signal Transduction Sirtuins Site Structure Sumoylation Pathway Surface Talents Technology Testing Therapeutic Therapeutic Intervention Therapeutic Uses Time Training Tumor Suppressor Genes Underrepresented Minority age related base cancer cell cancer therapy career career development drug discovery epigenetic regulation epigenetic silencing epigenome graduate student histone acetyltransferase human disease improved inhibitor/antagonist innovation insight interest meetings novel therapeutic intervention novel therapeutics overexpression palmitoylation posters prevent protein function response stem cell function stem cells success summer research symposium therapeutic target

项目摘要

Abstract Over the past few years, the “epigenetic” regulation of the genome has become increasingly important to understanding both the etiology and fundamental mechanisms of aging and age-related diseases. Key to epigenetic regulation are two classes of lysine-modifying enzymes, the histone deacetylases (sirtuins and HDACs) and the histone acetyltransferases (HATs), also known as erasers and writers, respectively. Acetyl- lysine neutralizes the cationic charge relative to the naked Lys sidechain and also creates an attractive surface for binding to proteins containing bromodomains, also known as reader proteins. These acetyl-Lys writers, erasers, and readers are critical for maintaining normal expression patterns, cell cycle progression, DNA repair, stem cells, mitochondria, cell fate, and differentiation. Alterations in the functions of these acetyl-Lys related proteins have been linked to epigenetic silencing of gene expression including tumor suppressor genes, leading to cancer cell proliferation. Moreover, changes in acetyl-Lys pathways are believed to contribute to a variety of other diseases and aging mechanisms. Several broad spectrum HDAC inhibitors have been approved by FDA to treat various cancers. Their precise molecular mechanisms in controlling cancer and influencing other biomedical processes remain elusive. Targeting HATs and HDACs for therapeutic purposes has been an area of great interest and success, and exciting new progress has also been made in recent years in targeting interactions between readers and acetylated lysines in cancer and other diseases. As the only conference dedicated to protein acetylation, this biannual meeting plays an essential role in bringing together more than 40 world leaders and ~120 participants. A primary objective is to transfer knowledge and foster collaboration between basic academic researchers, clinical scientists, and industrial researchers to understand how lysine acetylation controls human health and how to prevent and treat a diverse set of cancers and age-related diseases. A second objective is to foster the development and interests of younger investigators to help support their career development. The participants stay and eat at the meeting venue so they have ample time to for informal brainstorming and networking. There are 16 planned talks from junior scientists selected from the submitted abstracts and poster prize winners, which is important for their career development. We will also have a panel discussion on professional development and career options, aimed to provide further support for the young investigators. Moreover, there will be a diversity networking session, and multiple meet the speaker sessions that will be highlighted at the meeting. This meeting is particularly timely because of a linkage of acetylation, metabolism, and cancer. Furthermore, exciting new fundamental discoveries are continuing to be reported, such as the discovery of new lysine post-translational modifications (e.g. 3-hydroxybutyryl lysine and palmitoyl lysine) that can be removed by sirtuins or HDACs, and the discovery that these modifications can regulate transcription, cell signaling, and protein secretion. Therefore, support is requested for the 8th biannual FASEB conference on reversible protein acetylation in health and disease to be held in Dorado, Puerto Rico on August 9-14, 2021.

抽象的在过去的几年中，基因组的“表观遗传学调节”对了解衰老和与年龄有关的疾病的病因和基本机制。关键表观遗传调节是两类赖氨酸修饰酶，组蛋白脱乙酰基酶（Sirtuins和Sirtuins和 HDACS）和组蛋白乙酰转移酶（HATS），分别称为橡皮擦和作家。乙酰基赖氨酸中和阳离子电荷相对于裸露的Lys Sidechain，也产生了一个吸引人的表面用于结合含有溴生粒的蛋白质，也称为读取器蛋白。这些乙酰赖以释放的作家，橡皮擦和读者对于维持正常表达模式，细胞周期进程，DNA至关重要修复，干细胞，线粒体，细胞命运和分化。这些乙酰基透析功能的改变相关蛋白质已与基因表达的表观遗传沉默有关，包括肿瘤抑制剂基因，导致癌细胞增殖。此外，乙酰透析途径的变化被认为是有助于其他各种疾病和衰老机制。几种广谱HDAC抑制剂已获得FDA的批准来治疗各种癌症。它们在控制方面的精确分子机制癌症和影响其他生物医学过程仍然难以捉摸。靶向帽子和HDAC进行治疗目的一直是一个充满兴趣和成功的领域，并且也取得了令人兴奋的新进步近年来，癌症和其他疾病中读者与乙酰化歌词之间的相互作用。作为这次双年度会议是唯一致力于蛋白质乙酰化的会议，在带来共同有40多名世界领导人和约120名参与者。主要目标是转移知识，促进基础学术研究人员，临床科学家和工业研究人员之间的合作了解赖氨酸乙酰化如何控制人类健康以及如何预防和治疗各种癌症和与年龄有关的疾病。第二个目标是促进年轻的发展和利益调查人员帮助他们的职业发展。参与者在会议场所留下来吃饭他们有足够的时间进行非正式的集思广益和网络。初中有16次计划的会谈从提交的摘要和海报获奖者中选择的科学家，这对他们的职业很重要发展。我们还将进行有关专业发展和职业选择的小组讨论，以为年轻的调查人员提供进一步的支持。此外，将会有一个多样性网络会话，会议将在会议上强调的多个演讲者会议。这次会议特别及时由于乙酰化，代谢和癌症的联系。此外，令人兴奋的新基本发现发现的发现，例如发现新赖氨酸后翻译后修改（例如3-羟基丁酰胺赖氨酸和棕榈酰赖氨酸）可以通过sirtuins或hdacs去除，然后去除发现这些修饰可以调节转录，细胞信号传导和蛋白质分泌。所以，要求参加第八届双年度FASEB会议关于健康和疾病将于2021年8月9日至14日在波多黎各的多拉多举行。