Impact of Marijuana Legalization: Comparison of Two Longitudinal Twin Cohorts

大麻合法化的影响：两个纵向双胞胎群体的比较

• 批准号: 9402524
• 负责人: JOHN K. HEWITT
• 金额: $ 112.6万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9402524
• 关键词: 21 year old; Adolescence; Adult; Advocate; Affect; Age; Alcohol or Other Drugs use; Alcohols; Behavioral; Clinical; Colorado; Data; Dependence; Development; Environmental Monitoring; Event; Exposure to; Family; Frequencies; Functional disorder; Gender; Genetic; Genetic Predisposition to Disease; Genetic Risk; Geographic state; Health; Home environment; Illicit Drugs; Individual; Individual Differences; Industry; Laws; Legal; Life; Marijuana; Marijuana Dependence; Measurement; Measures; Medical Marijuana; Mental Health; Mental disorders; Minnesota; Mutation; Natural experiment; Nicotine; Outcome; Pattern; Policies; Population; Prevalence; Property; Psychological adjustment; Psychopathology; Public Health; Recreational Drugs; Research; Risk; Role; Sample Size; Sampling; Severities; Side; Social Impacts; Structure; Substance Addiction; Substance Use Disorder; Testing; Time; Twin Multiple Birth; Twin Studies; Work; alcohol availability; base; cohort; design; early adolescence; emerging adult; environmental change; experience; falls; follow up assessment; gender difference; high risk; marijuana legalization; marijuana use; marijuana use disorder; pill; population based; prospective; psychologic; psychosocial; resilience

PROJECT ABSTRACT We propose to examine the impact of recreational marijuana legalization on the development of marijuana use and marijuana use disorders, alcohol, nicotine, and other substance use and use disorders, and associated psychological adjustment and psychopathology. To do this, we will compare outcomes in two population based twin samples that have been followed longitudinally for over 15 years since adolescence. The age ranges of the samples at will be 23-39 at their follow-up assessment, thus, we will be able to examine the impact of legalization on early- to mid-adulthood functioning of family formation, work engagement, and adult role fulfillment. We will obtain additional waves of data in these samples in order to examine the effect of legalization on rates of marijuana, alcohol and other substance use and use disorders as well as associated psychological adjustment and psychopathology. One of these samples is from Colorado, which legalized adult recreational marijuana use in 2014 and now has widespread commercial marijuana readily available to consumers. The other sample is from Minnesota, which in 2014 legalized medical marijuana, with very strict limits on access, and has no recreational legalization. Together with our detailed prior longitudinal data, the new assessments, post-legalization of substance use, psychopathology, and psychosocial functioning in over 5000 population-based adult twins will provide unique and powerful data to understand the impact of recreational marijuana legalization and marijuana use on a wide variety of important outcomes. Furthermore, the effect of recreational marijuana legalization is unlikely to be uniform across the population. Rather, some individuals will be at higher risk to suffer negative consequences of RML, such as increased use and dependence. Leveraging the longitudinal and twin structure of the study, we will be able to determine the influence of pre-legalization individual differences in behavioral risk and psychosocial function on the effect of recreational marijuana legalization.

项目摘要 我们建议研究休闲大麻合法化对大麻使用开发的影响 大麻使用疾病，酒精，尼古丁和其他物质使用和使用障碍，以及相关的 心理调整和心理病理学。为此，我们将比较两个基于人群的结果 自青春期以来，已经纵向纵向遵循的双样本。年龄范围 在其后续评估中，样本将为23-39，因此，我们将能够检查 关于家庭形成，工作参与和成人角色的早期至中期运作的合法化 履行。我们将在这些样品中获得其他数据浪潮，以检查 大麻，酒精和其他物质使用和使用障碍的率以及相关的合法化 心理调整和心理病理学。这些样本之一来自科罗拉多州，该样本合法化成人 2014年的休闲大麻使用，现在很容易获得广泛的商业大麻 消费者。另一个样本来自明尼苏达州，该样本在2014年将医用大麻合法化，非常严格 限制访问，没有娱乐合法化。以及我们详细的先前纵向数据， 新的评估，物质使用后的合法化，心理病理学和社会心理功能 5000个基于人口的成人双胞胎将提供独特而强大的数据，以了解 娱乐性大麻合法化和大麻在各种重要结果上使用。此外， 休闲大麻合法化的影响不太可能在整个人群中统一。相反，有些 个人将面临RML负面后果的风险更高，例如使用增加和 依赖。利用研究的纵向和双胞胎结构，我们将能够确定 在行为风险和社会心理功能上的个人差异对个体差异的影响对 休闲大麻合法化。