Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 8291310
• 负责人: JOHN K. HEWITT
• 金额: $ 27.81万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8291310
• 关键词: Genetic; Research Training; Substance abuse problem

Seeinstructions): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBGfaculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 40 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques and the development of quantitative trait loci methods allow the mapping and identification of genes that regulate complex traits. Information from such analyses, along with neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, will provide an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays,gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees over a total period of 5 years. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in mental health include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory attendance in a course on the responsible conduct of research. RELEVANCE (See instructions): This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to the vulnerability to develop substance abuse. This understanding will lead to new approaches to the prevention and alleviation of substance abuse.

参见说明）： 该提案正在通过机构培训拨款寻求持续支持，以开展预科培训计划。 以及博士后研究员，他们将从事研究职业，重点研究遗传对人类的影响 药物滥用。 IBG 院系在研究方面表现出色且活跃，IBG 科学家积极致力于 40多年来一直致力于研究遗传对药物滥用的影响。主要与药物滥用相关 人类和动物行为遗传学方面的研究项目目前正在进行中。应用 生物统计、统计和数量遗传技术以及数量性状基因座的开发 这些方法可以对调节复杂性状的基因进行定位和鉴定。来自此类的信息 分析以及神经化学、神经药理学、神经生理学和分子遗传学 研究将提供对与行为相关的基因功能的理解。目前主要研究项目 人类和动物行为遗传学方面取得进展，包括大规模的国家合作研究 积累可用于药物滥用研究的 DNA 存储库和丰富的表型数据集。设施 可用于基因型测定，包括全基因组测定、基因功能和表达研究，以及 行为、生化和神经生理学研究。申请资金支持 4 名博士前和 2 名 博士后培训生总期限为5年。博士前培训生获得博士学位 行为遗传学合作学术单位和认证。培训中的学术要求 计划包括行为遗传学、定量和生物统计遗传学、理论和 基于计算机的统计、分子遗传学、生物信息学和基因组学、负责任的行为 研究以及行为和临床表型课程。附加要求因情况而异 授予学位的学术单位。研究经验是培训的一个组成部分。博士后实习生还 追求一个正式的计划，强调个人研究以及分子和技术方面的能力 定量行为遗传学。为心理健康研究生涯做准备的其他活动包括： 监督学生和/或技术人员、主持研讨会演讲者、客座讲座、每周期刊 俱乐部，并强制参加有关负责任的研究行为的课程。 相关性（参见说明）： 该提案旨在培训科学家，使他们能够为我们对遗传的理解做出重大贡献 导致药物滥用的脆弱性。这种理解将带来新的 预防和减轻药物滥用的方法。