Impact of Marijuana Legalization: Comparison of Two Longitudinal Twin Cohorts

大麻合法化的影响：两个纵向双胞胎群体的比较

• 批准号: 10192397
• 负责人: JOHN K. HEWITT
• 金额: $ 15.43万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10192397
• 关键词: Adolescence; Adult; Affect; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Anxiety; Behavior; COVID-19; COVID-19 pandemic; Cannabis; Cessation of life; China; Colorado; Data; Dependence; Diagnosis; Disease; Exposure to; Financial Hardship; Functional disorder; Gender; Goals; Grant; Home environment; Individual; Individual Differences; International; Legal; Legal Status; Marijuana; Marijuana Abuse; Market Research; Measurement; Medical Marijuana; Mental Depression; Mental Health; Mental disorders; Minnesota; Occupational; Participant; Pattern; Property; Psychopathology; Reporting; Research; Risk; Sales; Sample Size; Sampling; Social Distance; Stress; Substance Addiction; Substance Use Disorder; Testing; Time; Twin Multiple Birth; Twin Studies; Unemployment; United States; World Health Organization; base; behavioral disinhibition; cohort; coronavirus disease; drinking; drinking behavior; marijuana legalization; marijuana use; novel virus; parent grant; parent project; psychosocial; public health emergency; resilience; social; stressor; substance misuse; Adolescence; Adult; Affect; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Anxiety; Behavior; COVID-19; COVID-19 pandemic; Cannabis; Cessation of life; China; Colorado; Data; Dependence; Diagnosis; Disease; Exposure to; Financial Hardship; Functional disorder; Gender; Goals; Grant; Home environment; Individual; Individual Differences; International; Legal; Legal Status; Marijuana; Marijuana Abuse; Market Research; Measurement; Medical Marijuana; Mental Depression; Mental Health; Mental disorders; Minnesota; Occupational; Participant; Pattern; Property; Psychopathology; Reporting; Research; Risk; Sales; Sample Size; Sampling; Social Distance; Stress; Substance Addiction; Substance Use Disorder; Testing; Time; Twin Multiple Birth; Twin Studies; Unemployment; United States; World Health Organization; base; behavioral disinhibition; cohort; coronavirus disease; drinking; drinking behavior; marijuana legalization; marijuana use; novel virus; parent grant; parent project; psychosocial; public health emergency; resilience; social; stressor; substance misuse

This supplemental grant proposes to add questions to extend the aims of the parent project by collecting additional data related to COVID-19 including financial hardships, social/interpersonal problems, stress, mental health, and substance use changes. Data will also be collected on whether participants are essential workers, were exposed to COVID-19, or have been diagnosed with COVID-19. Parent grant Aim 1: Effect of RML on substance use/misuse, mental health, & psychosocial function Aim 1 extended: Effect of COVID-19 pandemic and RML on substance use/misuse, mental health & psychosocial function. We will test the hypothesis that access to RML increases the likelihood that the stress and disruption associated with COVID-19 will lead to increased marijuana use and abuse. Relatedly, we will test the extent to which increased marijuana use, related to RML and stress/disruptions from COVID-19, is accompanied by increases in other substance use, mental health disorders, or psychosocial dysfunction. Parent grant Aim 2: Individual differences in the effect of RML Aim 2 extended: Examine individual differences in the effect of COVID-19 pandemic and RML. Examine individual differences in the effects of COVID-19 and legalization by leveraging parallel multi-wave longitudinal twin studies in CO and MN, which both began collecting substance use, psychopathology, and psychosocial function during the twins' adolescence. This supplemental assessment will allow us to: a) identify how COVID-19 differentially impacts individuals depending on legalization and prior exposure to marijuana; b) examine how individuals differ in their vulnerability and resilience to the effects COVID-19, in the context of legalization, based on their individual level of risk (e.g., prior diagnosis of anxiety or depression); and c) examine if there are differential associations between COVID-19 and substance use/dependence, mental health, and psychosocial problems depending on legalization status and gender.

这项补充赠款提议添加问题，以通过收集来扩展父项目的目标 与COVID-19有关的其他数据，包括经济困难，社交/人际交往问题，压力，心理 健康和药物使用变化。还将收集有关参与者是否是必不可少的工人的数据， 暴露于Covid-19，或已被诊断为Covid-19。 父母赠款目标1：RML对药物使用/滥用，心理健康和社会心理功能的影响 AIM 1扩展：COVID-19-19大流行和RML对药物使用/滥用，心理健康的影响 社会心理功能。 我们将检验以下假设，即获得RML会增加压力和破坏的可能性 与Covid-19相关的19将导致大麻使用和滥用。相关，我们将测试 增加了与RML和Covid-19的压力/破坏有关的大麻使用的伴随 其他药物使用，心理健康障碍或社会心理功能障碍的增加。 父母赠款目标2：RML效应的个体差异 AIM 2扩展：检查COVID-19-19大流行和RML的影响的个体差异。 通过利用并行多波来检查COVID-19和合法化的效果的个体差异 CO和MN中的纵向双胞胎研究，两者都开始收集药物使用，心理病理学和 双胞胎青春期期间的社会心理功能。这种补充评估将使我们能够：a）确定 COVID-19如何根据合法化和事先接触大麻来差异化个人； b） 检查个人在脆弱性和对效果的抗韧性如何在Covid-19的背景下如何有所不同。 合法化，基于他们的个人风险水平（例如，事先诊断出焦虑或抑郁症）；和c） 检查COVID-19与药物使用/依赖性，心理之间是否存在差异关联 健康和社会心理问题，具体取决于合法化状况和性别。