Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 7880743
• 负责人: JOHN K. HEWITT
• 金额: $ 27.23万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7880743
• 关键词: Genetic; Research Training; Substance abuse problem

DESCRIPTION (provided by applicant): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBGfaculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 40 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques and the development of quantitative trait loci methods allow the mapping and identification of genes that regulate complex traits. Information from such analyses, along with neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, will provide an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays,gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees over a total period of 5 years. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in mental health include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory attendance in a course on the responsible conduct of research. This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to the vulnerability to develop substance abuse. This understanding will lead to new approaches to the prevention and alleviation of substance abuse.

描述（由申请人提供）：该提案正在通过机构培训拨款寻求持续支持，为博士前和博士后研究员提供培训计划，这些研究员将从事研究职业，重点研究遗传对药物滥用的影响。 IBG 学院在研究方面表现出色且活跃，40 多年来，IBG 科学家一直积极研究遗传对药物滥用的影响。与药物滥用相关的主要人类和动物行为遗传学研究项目目前正在进行中。生物统计、统计和数量遗传技术的应用以及数量性状基因座方法的发展使得能够绘制和鉴定调节复杂性状的基因。来自此类分析的信息以及神经化学、神经药理学、神经生理学和分子遗传学研究将提供对与行为相关的基因功能的理解。人类和动物行为遗传学方面的重大研究项目目前正在进行中，包括大规模的国家合作研究，积累了 DNA 存储库和丰富的表型数据集，可用于药物滥用研究。设施可用于基因型检测，包括全基因组检测、基因功能和表达研究以及行为、生化和神经生理学研究。请求资金支持 4 名博士前培训生和 2 名博士后培训生，为期 5 年。博士前培训生获得合作学术单位的博士学位和行为遗传学认证。培训计划的学术要求包括行为遗传学、定量和生物统计遗传学、理论和计算机统计、分子遗传学、生物信息学和基因组学、负责任的研究行为以及行为和临床表型课程的培训。附加要求根据授予学位的学术单位而有所不同。研究经验是培训的一个组成部分。博士后学员还追求一个正式的项目，强调个人研究以及分子和定量行为遗传学的能力。为心理健康研究生涯做准备的其他活动包括：对学生和/或技术人员的监督、主持研讨会演讲者、客座讲座、每周期刊俱乐部以及强制参加有关负责任的研究行为的课程。 该提案旨在培训科学家，他们将能够为我们了解遗传因素对药物滥用脆弱性的理解做出重大贡献。这种理解将带来预防和减轻药物滥用的新方法。