Gene Environment Contributions to Drug Use and Problem Behavior Trajectories

基因环境对药物使用和问题行为轨迹的贡献

• 批准号: 7718986
• 负责人: JOHN K. HEWITT
• 金额: $ 297.01万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718986
• 关键词: Adolescence; Adolescent; Age; Alcohol or Other Drugs use; Attention; Behavior; Biological; Candidate Disease Gene; Characteristics; DSM-IV; Data; Data Analyses; Data Set; Dependence; Development; Drug usage; Environment; Ethnic Origin; Gender; Gene Targeting; Genes; Genetic; Genetic Polymorphism; Genotype; Health; Individual; Life; Life Cycle Stages; Longitudinal Studies; Mediating; Outcome; Pathway interactions; Pattern; Problem behavior; Race; Risk; Risk-Taking; Sampling; Serotonin; Single Nucleotide Polymorphism; Single Nucleotide Polymorphism Map; Social Behavior; Subgroup; Substance of Abuse; System; Testing; Time; anti social; dopamine system; environmental stressor; externalizing behavior; genetic analysis; high risk sexual behavior; psychologic; response; social

Using four waves of data from Add Health, in this data analysis subproject we will examine the developmental trajectories of drug use and related behaviors, including conduct problems and risky sexual behavior. Genetic contributions will be examined in terms of their interaction with other biological, psychological, and social factors in a developmental life course framework. Attention to the developmental course and consequences of drug use leads to an emphasis on genetic polymorphisms in the dopamine system, some of which can be examined in detail through dense single nucleotide polymorphism (SNP) association studies of the candidate genes. Attention to the environmental influences on development leads to our simultaneous consideration of genotype by environment interactions, and to a consideration of genetic polymorphisms of the serotonin system that may mediate responses to environmental stressors and life transitions. We will: empirically determine trajectories of substance use and abuse from adolescence into young adulthood, and identify subgroups of individuals who reflect distinct patterns of continuity and change in substance use over time; describe how trajectories of substance use intersect with patterns of sexual risk taking and anti-social behavior; examine trajectories of substance use, and their covariation with sexual and anti-social behavior patterns, by gender and race/ethnicity to determine if there are patterns that are more characteristic of some groups versus others; examine genetic contributions to substance use trajectories and related health outcomes through biometrical analyses of the genetic pairs data; examine genetic contributions to substance use trajectories and related health outcomes through association tests of candidate genes including dense SNP mapping of specific target genes in the dopaminergic pathways implicated in the response to substances of abuse, and serotonergic pathways implicated in response to environmental stressors or adversity; examine gene X environment interactions in predicting the trajectories of substance use, and associated conduct problems, risky sexual behavior and related health outcomes, and whether these interactions vary by gender or race/ethnicity.

使用来自 Add Health 的四波数据，在这个数据分析子项目中，我们将检查发育 吸毒和相关行为的轨迹，包括行为问题和危险的性行为。遗传 将根据与其他生物、心理和社会因素的相互作用来审查贡献 在发展生命历程框架中。关注吸毒的发展过程和后果 导致对多巴胺系统遗传多态性的重视，其中一些可以进行详细检查 通过候选基因的密集单核苷酸多态性（SNP）关联研究。注意 环境对发展的影响导致我们同时考虑环境和基因型 相互作用，并考虑可能介导反应的血清素系统的遗传多态性 环境压力和生活转变。我们将： 凭经验确定物质使用轨迹和 从青春期到成年早期的虐待，并确定反映不同模式的个人亚组 物质使用随时间的连续性和变化；描述物质使用轨迹如何与 性冒险和反社会行为的模式；检查物质使用的轨迹及其协变 性和反社会行为模式，按性别和种族/民族确定是否存在以下模式： 与其他群体相比，某些群体更具特征；检查遗传对物质使用轨迹的贡献 通过基因对数据的生物识别分析得出相关的健康结果；检查遗传贡献 通过候选基因的关联测试来了解物质使用轨迹和相关的健康结果，包括 与物质反应有关的多巴胺能通路中特定靶基因的密集 SNP 作图 滥用以及与环境压力或逆境反应有关的血清素途径；检查基因 X 环境相互作用在预测物质使用轨迹和相关行为问题方面存在风险 性行为和相关的健康结果，以及这些相互作用是否因性别或种族/民族而异。