Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 9457003
• 负责人: JOHN K. HEWITT
• 金额: --
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9457003
• 关键词: Genetic; Research Training; Substance abuse problem

DESCRIPTION (provided by applicant): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBG faculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 45 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in our understanding. Neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays, gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in substance abuse include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory training in the responsible conduct of research and the development of individual professional plans.

描述（由申请人提供）：该提案正在通过机构培训补助金寻求持续支持，该培训计划针对博士后和博士后研究员进行培训计划，他们将追求研究研究对遗传影响对药物滥用的影响的研究职业。 IBG教师在研究方面具有杰出作用和积极性，IBG科学家已经积极地研究了45年以上的遗传影响对药物滥用的研究。人类和动物行为遗传学中，与药物滥用相关的主要研究项目现在正在进行中。生物识别，统计和定量遗传技术的应用，以及生物信息学，全基因组分析以及下一代测序以及表观遗传学，在我们的理解中提供了真正的进步。神经化学，神经药理，神经生理学和分子遗传研究正在提供与行为相关的基因功能的理解。目前，人类和动物行为遗传学的主要研究项目正在进行中，包括大规模的国家合作研究积聚了DNA存储库和丰富的表型数据集可用于滥用药物的研究。设施可用于基因型测定，包括全基因组测定，基因功能和表达研究以及行为，生化和神经生理学研究。要求资金支持4个占主导地位和2个博士后学员。托管前学员获得合作学术单位和行为遗传学认证的博士学位。培训计划中的学术要求包括行为遗传学，定量和生物遗传学，基于理论和计算机的统计数据，分子遗传学，神经科学，生物信息学和基因组学，负责研究的研究以及行为和临床表型的课程。其他要求根据授予学位单位的程度而有所不同。研究经验是培训的组成部分。博士后学员还采用了一个正式的计划，该计划强调了个人研究以及分子和定量行为遗传学的能力。为滥用毒品的研究职业准备的其他活动包括：对学生和/或技术人员的监督，主持研讨会演讲者，嘉宾讲座，每周期刊俱乐部以及负责任的研究以及个人专业计划的制定的强制性培训。