Monkey model of Alzheimer's disease

阿尔茨海默病的猴子模型

• 批准号: 7732213
• 负责人: Julie Mattison
• 金额: $ 13.9万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732213
• 关键词: Accounting; Alzheimer' s Disease; Alzheimer' s disease model; Amyloid beta-Protein; Animal Model; Brain; Chemicals; Deposition; Dose; Effectiveness; Elderly; Genes; Human; Injection of therapeutic agent; Learning; Lesion; Longitudinal Studies; Macaca mulatta; Measures; Memory; Monkeys; Mus; Pathology; Pilot Projects; Rodent; Saimiri; day; interest; locus ceruleus structure; mutant; neuroinflammation; nonhuman primate; noradrenergic

A pilot study was completed in both rhesus and squirrel monkeys to determine the efficacy of the DSP-4 injection. Thirty days following injection, monkeys were euthanized and brain sections were analyzed for noradrenergic depletion. In the regions of interest, there was 60-75% depletion confirming the effectiveness of the DSP-4. Subsequently, a longitudinal study was initiated first in squirrel monkeys. Monkeys received an initial dose and a booster dose at 3 and 6 months and were terminated at 9 months. Quantification of the noradrenergic depletion is underway. The parallel study in rhesus monkeys is ongoing with an additional measure of learning and memory.

在恒河猴和松鼠猴子都完成了一项试点研究，以确定DSP-4注射的功效。注射后的30天，对猴子进行安乐死，并分析了脑切片的去甲肾上腺素能耗竭。在感兴趣的地区，有60-75％的耗竭证实了DSP-4的有效性。随后，首先在松鼠猴子中开始了一项纵向研究。猴子在3和6个月时接受了初始剂量和助推器剂量，并在9个月时终止。去甲肾上腺素能耗竭的定量正在进行中。在恒河猴中进行的并行研究正在进行中，并具有额外的学习和记忆量度。