Primate Aging Studies

灵长类动物衰老研究

• 批准号: 10913056
• 负责人: Julie Mattison
• 金额: $ 123.12万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10913056
• 关键词: Age of Onset; Aging; Animals; Attenuated; Behavior; Biological Markers; Body Composition; Brain; Caloric Restriction; Cardiovascular Physiology; Diet; Disease; Energy Intake; Fasting; Goals; Health; Human; Incidence; Intervention; Learning; Longevity; Longitudinal Studies; Macaca mulatta; Macular degeneration; Mammals; Memory; Metabolic; Monitor; Monkeys; Outcome; Primates; Process; Publishing; Reporting; Research; Research Design; Serum; Stress; Testing; Time; Tissue Sample; Tissues; Universities; Wisconsin; age related; burden of illness; comparison control; functional decline; healthspan; immune function; improved; nonhuman primate; programs; reproductive function; survival outcome

Caloric restriction (CR: reducing caloric intake 30-40 percent below ad libitum levels) has been repeatedly shown to extend lifespan, reduce the incidence and delay the onset of age-related disease, enhance stress protection, and attenuate functional decline in mammals. The NIA longitudinal study of CR and aging in rhesus monkeys is in its 35th year and 7% of the animals remain on study. In 2012, we reported findings of improved health; however, unlike findings from a similar study at the University of Wisconsin (UW), the NIA CR monkeys did not have improved survival compared to the controls. In 2017, we compared the study designs and outcomes concluding that aging is malleable in primates and a reasonable target for intervention. Here, we demonstrated that the amount of time fasting may be more important than the diet contents for survival outcomes. We are continuing to monitor the monkeys for age-related changes in many health parameters and monkeys are currently tested on learning and memory tasks. Additionally, tissue and serum are used to assess biomarkers of aging.

热量限制（CR：降低热量降低30-40％的热量摄入量）已反复证明可以延长寿命，降低发病率并延迟与年龄相关疾病的发作，增强压力保护并减轻哺乳动物的功能下降。恒河猴中CR和衰老的NIA纵向研究已在其第35年，其中7％的动物仍在研究中。 2012年，我们报道了改善健康状况的结果。但是，与威斯康星大学（UW）的类似研究的发现不同，与对照组相比，Nia Cr猴子的生存率没有提高。在2017年，我们比较了研究设计和结果，得出的结论是，衰老是可以在灵长类动物中延展的，并且是干预的合理目标。在这里，我们证明了禁食的时间比生存结果的饮食含量更重要。目前，我们将继续监视猴子是否在学习和记忆任务上测试了许多健康参数和猴子的年龄相关变化。另外，组织和血清用于评估衰老的生物标志物。

项目成果

Watch the Clock, Not the Scale.

注意时钟，而不是秤。

• DOI: 10.1016/j.cmet.2018.05.016
• 发表时间: 2018
• 期刊: Cell metabolism
• 影响因子: 29
• 作者: Vaughan,KelliL;Mattison,JulieA
• 通讯作者: Mattison,JulieA

An overview of nonhuman primates in aging research.

• DOI: 10.1016/j.exger.2016.12.005
• 发表时间: 2017-08
• 期刊: Experimental gerontology
• 影响因子: 3.9
• 作者: Mattison JA;Vaughan KL
• 通讯作者: Vaughan KL

Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction.

• DOI: 10.18632/aging.100598
• 发表时间: 2013-09
• 期刊: Aging
• 作者: Mercken EM;Majounie E;Ding J;Guo R;Kim J;Bernier M;Mattison J;Cookson MR;Gorospe M;de Cabo R;Abdelmohsen K
• 通讯作者: Abdelmohsen K

Response to Le Bourg.

对勒布尔的回应。

• DOI: 10.1093/gerona/glx173
• 发表时间: 2018
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Mattison,JulieA;Colman,RickiJ
• 通讯作者: Colman,RickiJ