Primate Aging Studies

灵长类动物衰老研究

• 批准号: 8736544
• 负责人: Julie Mattison
• 金额: $ 57.04万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8736544
• 关键词: Aging; Aging-Related Process; Attenuated; Behavior; Body Composition; Caloric Restriction; Cardiovascular Physiology; Disease; Energy Intake; Future; Goals; Health; Human; Incidence; Intervention Studies; Intestinal Cancer; Longevity; Longitudinal Studies; Macaca mulatta; Macular degeneration; Mammals; Metabolic; MicroRNAs; Monitor; Monkeys; Motor; Muscle; Ophthalmic examination and evaluation; Performance; Physiology; Primates; Publishing; Relative (related person); Reporting; Role; Sampling; Stress; Universities; Wisconsin; age related; brain behavior; functional decline; gut microbiota; immune function; improved; nonhuman primate; reproductive function; sample collection; trait

Caloric restriction (CR: reducing caloric intake 30-40 percent below ad libitum levels) has been repeatedly shown to extend lifespan, reduce the incidence and delay the onset of age-related disease, enhance stress protection, and attenuate functional decline in mammals. The NIA longitudinal study of CR and aging in rhesus monkeys is in its 25th year and recently published the survival findings. We reported findings of improved health; however, unlike findings from a similar study at the University of Wisconsin, the NIA CR monkeys did not have improved survival compared to the controls. Both studies are ongoing and we will continue to monitor the monkeys for age-related changes in many health parameters. Specifically we have ongoing studies assessing behavior including locomotor and motor performance. We have recently completed eye exams identifying traits consistent with macular degeneration. The monkeys have now had 5 exams in the last 7 years. We completed sample collection to identify markers consistent with intestinal cancers that might be similar between monkeys and humans. Additionally, fecal samples will be analyzed for the gut microbiota and compared to monkeys on the Wisconsin study and humans practicing CR.

热量限制（CR：降低热量降低30-40％的热量摄入量）已反复证明可以延长寿命，降低发病率并延迟与年龄相关疾病的发作，增强压力保护并减轻哺乳动物的功能下降。 NIA的恒河猴CR和衰老的纵向研究已成立25年，最近发表了生存结果。我们报道了改善健康的结果；但是，与威斯康星大学类似研究的发现不同，与对照组相比，Nia Cr猴子的生存率没有提高。这两项研究都在进行中，我们将继续监视猴子的许多健康参数变化。具体而言，我们正在进行评估包括运动和运动性能在内的行为的持续研究。我们最近完成了眼科检查，以识别与黄斑变性一致的特征。在过去的7年中，猴子现在有5项考试。我们完成了样本收集，以识别与猴子和人类之间可能相似的肠癌一致的标记。此外，将分析肠道菌群的粪便样品，并将其与威斯康星州研究的猴子进行比较。