Resveratrol treatment in monkeys

白藜芦醇对猴子的治疗

• 批准号: 8552388
• 负责人: Julie Mattison
• 金额: $ 5.19万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8552388
• 关键词: Aging; Antioxidants; Biopsy; Blood Chemical Analysis; Body Composition; Cardiovascular system; Data; Data Collection; Diet; Fatty acid glycerol esters; Glucose tolerance test; Health; Health Benefit; Learning; Longevity; Macaca mulatta; Manuscripts; Measures; Memory; Mitochondria; Monitor; Monkeys; Motor; Motor Activity; Mus; Obesity; Ophthalmic examination and evaluation; Organ; Pathology; Physiologic pulse; Placebos; Plants; Process; Property; Resveratrol; Serum Markers; Tissue Sample; Tissues; Weight; feeding; follow-up; immune function; insulin sensitivity; sugar

Twenty-four rhesus monkeys were divided into treatment groups. Twenty of the monkeys were fed an obesity-inducing diet high in fat and sugar; ten of these monkeys received 40 mg resveratrol twice a day for year one, followed by 240mg resveratrol during year 2, ten monkeys got a placebo. Four monkeys remained on a healthy weight stable diet without resveratrol to serve as controls. Monkeys were monitored regularly and follow up data collection occurred every three months. Data variables include body composition, glucose tolerance test, immune function, eye exams, pulse wave velocity, locomotor activity, and blood chemistry. Tissue biopsies were collected at baseline and year 1. The monkeys were sacrificed after 2 years on study and tissue samples were collected, processed and preserved. Analysis of all the tissue is ongoing. One manuscript has been submitted and two others are in final edits prior to submission.

二十四只恒河猴被分为治疗组。二十只猴子被喂食肥胖的饮食高脂肪和糖。其中十只猴子每天两次获得40毫克白藜芦醇，然后在2年级的240毫克白藜芦醇中接受了240毫克的白藜芦醇，十只猴子得到了安慰剂。四只猴子保持健康的体重稳定饮食，而没有白藜芦醇作为对照。 定期监控猴子，并每三个月进行一次随访数据收集。 数据变量包括身体成分，葡萄糖耐量测试，免疫功能，眼科检查，脉搏波速度，运动活性和血液化学。在基线和第1年收集组织活检。 研究2年后，牺牲猴子，并收集，处理和保存组织样品。对所有组织的分析正在进行中。提交了一份手稿，另外两个手稿在提交之前进行了最终编辑。