Acute metabolic and gene expression changes to diet

饮食的急性代谢和基因表达变化

• 批准号: 8552380
• 负责人: Julie Mattison
• 金额: $ 17.3万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8552380
• 关键词: Acute; Affect; Aging; Animals; Biological Markers; Body Composition; Body Weight; Caloric Restriction; Crossover Design; Data Collection; Diet; Disease; Fatty acid glycerol esters; Gene Expression; Genetic; Glucose tolerance test; Longevity; Longitudinal Studies; Macaca mulatta; Measures; Metabolic; Monkeys; Morbidity - disease rate; Muscle; Physiologic pulse; Plasma; Randomized; Sampling; Scanning; Site; United States National Institutes of Health; Wisconsin; age related; arterial stiffness; liver biopsy; mortality; prevent; response

Monkeys were randomized into study groups for a cross over design evaluating the acute effects of 3 different monkey diets: standard NIH chow, the NIA 1-87 diet, and the Wisconsin Harlan Teklad diet. The latter two diets are used at the respective sites for long-term studies of calorie restriction effects on function, morbidity, and mortality. For baseline and each 3-month timepoint, the following measures were collected: body weight, morphometric measures, body composition scan, pulse wave velocity for arterial stiffness, glucose tolerance test, biopsy of liver, fat and muscle, and banked serum and plasma samples. All data collection was completed this year and samples are currently being analyzed.

将猴子随机分为研究组，以评估3种不同的猴子饮食的急性影响：标准NIH Chow，NIA 1-87饮食和威斯康星州Harlan Teklad Diet。后两种饮食在各个部位用于对卡路里限制对功能，发病率和死亡率的影响的长期研究。对于基线和每个3个月的时间点，收集了以下措施：体重，形态计量测量，身体组成扫描，动脉僵硬度的脉搏波速度，葡萄糖耐受性测试，肝脏，脂肪和肌肉的活检以及储存的血清和血浆样品。所有数据收集均已完成，目前正在分析样本。