The impact of bilingualism on cognitive reserve/resilience using socio-demographically and linguistically diverse populations

双语对社会人口和语言多样化人群的认知储备/弹性的影响

• 批准号: 10584245
• 负责人: Suvarna Alladi
• 金额: $ 94.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10584245
• 关键词: Accounting; Address; Age; Age of Onset; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Amyloid beta-42; Anterior; Attention; Biological; Biological Markers; Brain; Brain Pathology; California; Cerebrum; Chinese; Chinese American; Chronic stress; Cognition; Cognitive; Corpus Callosum; Correlation Studies; Data; Dementia; Diagnostic; Dimensions; Education; English Language; Ethnic Population; Factor Analysis; Frequencies; Functional Magnetic Resonance Imaging; Glial Fibrillary Acidic Protein; Goals; Health; Image; Impaired cognition; India; Individual; Investigation; Joints; Language; Language Development; Learning; Light; Linguistics; Link; Longitudinal cohort; Measures; Mexican Americans; Multilingualism; National Institute of Mental Health; Neurocognitive; Neurosciences; Outcome; Persons; Population; Population Heterogeneity; Population Study; Prevalence; Publishing; Research; Research Project Grants; Role; San Francisco; Series; Severity of illness; Socioeconomic Status; Texas; Universities; Visit; Work; Writing; aging brain; bilingualism; cognitive performance; cognitive reserve; cohort; dementia risk; design; executive function; experience; follow-up; health care availability; health disparity; health disparity populations; healthy aging; imaging biomarker; improved; insight; lens; mild cognitive impairment; molecular marker; neighborhood disadvantage; neural; neurofilament; neuromechanism; novel; protective effect; racial population; resilience; social culture; social health determinants; sociocultural determinant; sociodemographics; stem; study population; tau Proteins; Accounting; Address; Age; Age of Onset; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Amyloid beta-42; Anterior; Attention; Biological; Biological Markers; Brain; Brain Pathology; California; Cerebrum; Chinese; Chinese American; Chronic stress; Cognition; Cognitive; Corpus Callosum; Correlation Studies; Data; Dementia; Diagnostic; Dimensions; Education; English Language; Ethnic Population; Factor Analysis; Frequencies; Functional Magnetic Resonance Imaging; Glial Fibrillary Acidic Protein; Goals; Health; Image; Impaired cognition; India; Individual; Investigation; Joints; Language; Language Development; Learning; Light; Linguistics; Link; Longitudinal cohort; Measures; Mexican Americans; Multilingualism; National Institute of Mental Health; Neurocognitive; Neurosciences; Outcome; Persons; Population; Population Heterogeneity; Population Study; Prevalence; Publishing; Research; Research Project Grants; Role; San Francisco; Series; Severity of illness; Socioeconomic Status; Texas; Universities; Visit; Work; Writing; aging brain; bilingualism; cognitive performance; cognitive reserve; cohort; dementia risk; design; executive function; experience; follow-up; health care availability; health disparity; health disparity populations; healthy aging; imaging biomarker; improved; insight; lens; mild cognitive impairment; molecular marker; neighborhood disadvantage; neural; neurofilament; neuromechanism; novel; protective effect; racial population; resilience; social culture; social health determinants; sociocultural determinant; sociodemographics; stem; study population; tau Proteins

PROJECT SUMMARY Alzheimer’s disease (AD) is the most common form of dementia, impacting millions of people globally. Despite the advancements in understanding fundamental biological constructs of AD and the fact that the global population of bilinguals has outnumbered monolinguals, our understanding of the impact of bilingualism on AD/ADRD (AD and related dementias) remains limited. Previous bilingualism studies suggest that the bilingual experience impacts cognition and AD/ADRD, albeit in varying scale that stems from variabilities in demographic profiles and prevalence of ADRD risk factors. The overarching goal of this study is to directly interrogate the neural and sociocultural aspects of bilingualism across multiple race/ethnic groups, with specific emphasis on deconstructing the links between bilingualism and AD. To accomplish this, the University of California, San Francisco Alzheimer's Disease Research Center in California, the National Institute of Mental Health and Neurosciences in India, and the Health and Aging Brain Study- Health Disparities study in Texas will jointly assemble one of the largest, multicultural, multilingual, and well-characterized cohort of 2,200 individuals representing the world’s most commonly spoken languages: Chinese, Spanish, Kannada, and English languages. This study team will collect cross-sectional data on cognition, imaging, molecular biomarkers, language background, and SDOH, and follow-up language, SDOH, and cognitive data for three years. We intend to build a theoretical framework on the cognitive role of bilingualism by deconstructing bilingualism and examining its features via a multidimensional lens. We will examine the inter-relationship of this multidimensional bilingualism construct with cognition and social determinants of health using structural and functional magnetic resonance imaging and AD/ADRD molecular biomarkers. Our central hypothesis is that specific bilingualism features would influence the cognitive trajectory by improving executive control through the mechanism of brain and cognitive reserve even after accounting for social determinants of health and AD/ADRD biomarkers. This proposed study will provide novel mechanistic insights into the multidimensionality of bilingualism and create an exclusive opportunity to study the cognitive relevance of bilingualism using socio-demographically and linguistically diverse cohorts. This study also has the unique settings to evaluate the generalizability of the proposed cognitive-bilingualism theoretical framework across populations that differ in sociocultural, demographic, and linguistic background.

项目摘要 阿尔茨海默氏病（AD）是痴呆症的最常见形式，影响了全球数百万的人。 尽管在理解AD的基本生物学结构方面取得了进步以及全球的事实 双语者的人口具有外部单语言，我们对双语对的影响 AD/ADRD（AD和相关痴呆症）仍然有限。以前的双语研究表明双语 经验影响认知和广告/ADRD，尽管规模不同，从人口统计学的变异中迈出了变化 ADRD风险因素的概况和患病率。 这项研究的总体目标是直接询问双语的神经和社会文化方面 在多个种族/族裔群体中，特别强调双语与双语之间的联系 广告。为此，加利福尼亚大学，旧金山阿尔茨海默氏病研究中心 加利福尼亚州，印度国家心理健康与神经科学研究所以及健康与衰老的大脑 德克萨斯州的研究 - 健康差异研究将共同​​组成最大的，多元文化，多语言和 代表世界上最常见的语言的2200个人的特征良好的队列： 中文，西班牙语，卡纳达语和英语语言。 该研究团队将收集有关认知，成像，分子生物标志物，语言的横断面数据 背景和SDOH以及后续语言，SDOH和认知数据已有三年了。我们打算建造 通过解构双语和检查其双语的认知作用的理论框架 通过多维镜头的功能。我们将研究这种多维双语的关系 使用结构和功能性磁共振结构和社会决定者的认知和社会决定者构建 成像和AD/ADRD分子生物标志物。我们的中心假设是特定的双语特征将 通过大脑的机制改善执行控制，影响认知轨迹 在考虑了健康和AD/ADRD生物标志物的社会决定者之后，也可以保留。 这项拟议的研究将为双语和 创造一个独家机会，使用社会人口统计学和 语言上多样化的队列。这项研究还具有独特的设置来评估 拟议的认知文学主义理论框架跨越社会文化， 人口统计和语言背景。