Expansion of Marmoset Breeding Facilities to Meet Increasing Research Demands

扩建狨猴饲养设施以满足不断增长的研究需求

• 批准号: 9933536
• 负责人: Larry S. Schlesinger
• 金额: $ 50万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-23 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9933536
• 关键词: Aging; Animal Housing; Animals; Area; Biomedical Research; Breeding; Callithrix; Callithrix jacchus jacchus; Communicable Diseases; Communities; Custom; Fertility; Funding; Health; Housing; Human; Human Resources; Infrastructure; Modeling; Monkeys; Neurosciences; Population; Positioning Attribute; Primates; Prize; Production; Research; Resources; Sales; Shunt Device; Training; Transgenic Organisms; Weaning; Zika Virus; aging gene; design; flexibility; improved; vaccine evaluation

The common marmoset (Callithrix jacchus) is becoming an increasingly important biomedical research model in neuroscience, aging and infectious disease. Due to its small size, fast maturation, and high fertility, this species is particularly prized for research into aging, gene editing and transgenic production. There is clear evidence of unmet demand for marmosets by the US research community, pointing to the value of increasing marmoset production. The Southwest National Primate Research Center (SNPRC) has the trained personnel and infrastructure in place to effectively and efficiently breed additional marmosets. Of particular importance, we have the largest population of marmosets in the US and can, therefore, most rapidly expand the breeding population without encountering the issue of having to search elsewhere for additional animals to put into breeding. However SNPRC is limited in the extent to which we can expand production by appropriate housing space, caging and support to shunt animals away from sales and research and into breeding. We therefore are requesting support for: (1) Housing Space. While the center has more than adequate land for expansion, we do require additional, appropriate indoor housing in order to expand production. The most expedient way to increase production capacity is the placement of a custom-designed modular building in association with our other marmoset housing. The proposed modular building would provide approximately 1,008 sq ft of additional animal housing space, increasing our housing space for production by approximately 75%. (2) Caging. Our rationale for the marmoset caging request is to both increase our capacity to house this species but, perhaps more importantly, to provide us with flexible caging options that can be used for pair-housing, small group housing or large group housing. We project that the support provided by this supplement would allow us within 2.5 years to support 64 breeding units as opposed to the 36 we presently support, increasing our weaned production per year from 90-110 animals to 160-192 animals - an approximately 75% increase. This will position SNPRC to rapidly increase production, if mechanisms of support for moving marmosets from sales or research into breeding become available in the coming year.

普通狨猴（Callithrix jacchus）正在成为越来越重要的生物医学研究模型 在神经科学、衰老和传染病方面。由于其体型小、成熟快、受精率高， 该物种因衰老、基因编辑和转基因生产的研究而受到特别重视。有明确的 美国研究界对狨猴的需求未得到满足的证据，表明增加狨猴的价值 狨猴生产。西南国家灵长类研究中心（SNPRC）拥有经过培训的人员 以及有效和高效繁殖更多狨猴的基础设施。特别重要的是， 我们拥有美国最大的狨猴种群，因此可以最迅速地扩大繁殖 人口，而不会遇到必须在其他地方寻找更多动物来放入的问题 选育。然而，SNPRC 通过适当的住房来扩大生产的程度是有限的 空间、笼子和支持，将动物从销售和研究转移到繁殖。我们因此 请求支持： (1) 住房空间。虽然该中心有足够的土地用于扩建， 我们确实需要额外的、适当的室内住房以扩大生产。最方便的方法 为了提高生产能力，我们将定制设计的模块化建筑与我们的 其他狨猴的住房。拟议的模块化建筑将提供约 1,008 平方英尺的额外空间 动物饲养空间，使我们的生产饲养空间增加了约 75%。 (2)笼养。我们的 狨猴笼养要求的理由是为了提高我们容纳该物种的能力，但也许 更重要的是，为我们提供灵活的笼养选择，可用于配对住房、小团体 住房或大型团体住房。我们预计该补充提供的支持将使我们能够在 2.5 年支持 64 个育种单位（而不是我们目前支持的 36 个），从而增加我们的断奶仔数 年产量从 90-110 只动物增加到 160-192 只动物——增加了约 75%。这将 如果有支持狨猴停止销售的机制或 育种研究将于明年投入使用。