Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)

跨学科 NexGen 结核病研究推进中心 (IN-TRAC)

基本信息

批准号：
10588203
负责人：
Larry S. Schlesinger
金额：
$ 115.01万
依托单位：
TEXAS BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-10 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10588203
关键词：
Address Animal Model Animals Biomedical Research Chest Cities Clinic Clinical Clinical Management Clinical Research Clinical Services Communicable Diseases Communication Communities Complement Comprehension Confocal Microscopy Country Cytometry Development Discipline Educational Curriculum Funding Funding Agency Grant Health Health Professional Hospitals IACUC Image Individual Industry Inpatients Interdisciplinary Study Internships Knowledge Leadership Learning Mechanics Mexico Mission Mus National Institute of Allergy and Infectious Disease Outpatients PET/CT scan Participant Patient Care Prevention Procedures Protocols documentation Research Research Institute Research Personnel Resources Risk Assessment Rodent Science Scientist Site Texas Training Training Programs Tuberculosis United States National Institutes of Health Universities Work Writing biocontainment facility career development cellular imaging cohort commercialization experience externship live cell imaging metropolitan multidisciplinary next generation nonhuman primate organizational structure peer point of care prevent programs prospective single-cell RNA sequencing skills success tool whole body imaging

项目摘要

TEXAS BIOMED IN-TRAC OVERALL ABSTRACT The Interdisciplinary NexGen TB Research Advancement Center (IN-TRAC) at Texas Biomedical Research Institute (Texas Biomed) will attract the next generation of diverse researchers to the tuberculosis (TB) research field, and develop them into independent researchers with multi-disciplinary skills and real-world experience of clinical TB. The product of IN-TRAC will be researchers that choose to work on some of the most challenging and relevant translational problems in TB, and that work across academic disciplines and within a framework of highly collaborative research. This will be achieved through 6 interrelated Cores. Administrative Core: The central hub of IN-TRAC management and oversight, with responsibility for administrative and scientific leadership; coordinating communication between Cores, researchers and NIH/NIAID Program staff and providing an organizational structure to optimize multidisciplinary collaborations and interactions between the Cores and among a diverse cohort of IN-TRAC participants. Development Core: Oversight of all career development programming and courses, tailoring the research and clinical experiences, both intern and externships, to each individual IN-TRAC participant, and management of the IN-TRAC pilot grant program. Biosafety & Biocontainment Core: Extending the required biosafety training to a personalized curriculum including theoretical and hands-on biocontainment training, understanding the mechanical and regulatory requirements of a BSL3/ABSL3, coaching on how to develop biosafety protocols, and working through risk assessments from the perspective of a Biosafety Officer. Research Imaging Core: Providing theoretical and hands-on training from single cell imaging (confocal microscopy, cytometry, live cell imaging, single cell RNAseq) through to whole body imaging in mice (IVIS) and Non-human primates (NHP) (PET/CT) within large, fully outfitted BSL3/ABSL3 facilities. Animal Model Core: Implementing a training program to introduce all IN-TRAC participants to the regulatory requirements for working with rodents and NHPs, how to develop a robust experimental protocol, how to write an IACUC protocol, and hands-on animal handling and experimental procedures. Clinical Research & Patient Care Core: Introducing IN-TRAC participants to TB patient care at the only free-standing TB hospital in the US (Texas Center of Infectious Diseases) that manages some of the most challenging cases of TB nationally. Partnering with this will be a clinical research experience at the US- Mexico border, to experience TB studies in under-served and under-resourced communities.

德克萨斯州生物术中的整体抽象德克萨斯生物医学研究的跨学科Nexgen TB研究进步中心（IN-TRAC）研究所（得克萨斯州生物元素）将吸引下一代多元化研究人员进行结核病研究（TB）研究领域，并将其发展为具有多学科技能和现实世界经验的独立研究人员临床结核TRAC的产物将是研究人员，他们选择从事一些最具挑战性的工作以及结核病中的相关翻译问题，以及在学科跨学科以及在一个框架内的工作高度协作研究。这将通过6个相互关联的内核来实现。行政核心：贸易管理和监督的中央枢纽，负责行政和科学领导;协调核心，研究人员与NIH/NIAID计划人员之间的沟通以及提供组织结构，以优化多学科的合作以及核心以及各种各样的搜索参与者。发展核心：对所有职业的监督开发计划和课程，量身定制研究和临床经验实习，对每个个人进水参与者以及贸易中试点赠款计划的管理。生物安全与生物内在核心核心：将所需的生物安全培训扩展到个性化课程包括理论和动手生物内在培训，了解机械和调节性 BSL3/absl3的要求，有关如何制定生物安全协议的指导以及通过风险进行的从生物安全官员的角度进行评估。研究成像核心：提供理论和单细胞成像（共聚焦显微镜，细胞术，活细胞成像，单细胞RNASEQ）的动手训练通过小鼠（IVI）和非人类灵长类动物（NHP）（PET/CT）的全身成像到全身成像装备的BSL3/ABSL3设施。动物模型核心：实施培训计划以介绍所有轨道参与者满足与啮齿动物和NHP合作的监管要求，如何开发强大的实验方案，如何编写IACUC协议以及动物动物处理和实验程序。临床研究与患者护理核心：将Trac In-Trac参与者引入结核病患者护理美国唯一的独立结核病医院（得克萨斯州传染病中心）管理了一些全国结核病的最具挑战性案例。与此合作将是美国的临床研究经验墨西哥边境，在服务不足和资源不足的社区中进行结核病研究。