Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)

跨学科 NexGen 结核病研究推进中心 (IN-TRAC)

基本信息

批准号：
10431465
负责人：
Larry S. Schlesinger
金额：
$ 119.94万
依托单位：
TEXAS BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-10 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10431465
关键词：
Address Animal Model Animals Biomedical Research Chest Cities Clinic Clinical Clinical Management Clinical Research Clinical Services Communicable Diseases Communication Communities Community Healthcare Complement Comprehension Confocal Microscopy Country Cytometry Development Discipline Disease Management Educational Curriculum Ensure Funding Funding Agency Grant Health Health Professional Hospitals IACUC Image Individual Industry Inpatients Institutes Interdisciplinary Study Internships Knowledge Leadership Learning Mechanics Mexico Mission Mus National Institute of Allergy and Infectious Disease Outpatients PET/CT scan Participant Patient Care Prevention Procedures Protocols documentation Research Research Institute Research Personnel Resources Risk Assessment Rodent Science Scientist Site Texas Training Training Programs Tuberculosis United States National Institutes of Health Universities Work Writing biocontainment facility career development cellular imaging cohort commercialization experience externship live cell imaging metropolitan multidisciplinary next generation nonhuman primate organizational structure peer point of care prevent programs prospective single-cell RNA sequencing skills success tool whole body imaging

项目摘要

TEXAS BIOMED IN-TRAC OVERALL ABSTRACT The Interdisciplinary NexGen TB Research Advancement Center (IN-TRAC) at Texas Biomedical Research Institute (Texas Biomed) will attract the next generation of diverse researchers to the tuberculosis (TB) research field, and develop them into independent researchers with multi-disciplinary skills and real-world experience of clinical TB. The product of IN-TRAC will be researchers that choose to work on some of the most challenging and relevant translational problems in TB, and that work across academic disciplines and within a framework of highly collaborative research. This will be achieved through 6 interrelated Cores. Administrative Core: The central hub of IN-TRAC management and oversight, with responsibility for administrative and scientific leadership; coordinating communication between Cores, researchers and NIH/NIAID Program staff and providing an organizational structure to optimize multidisciplinary collaborations and interactions between the Cores and among a diverse cohort of IN-TRAC participants. Development Core: Oversight of all career development programming and courses, tailoring the research and clinical experiences, both intern and externships, to each individual IN-TRAC participant, and management of the IN-TRAC pilot grant program. Biosafety & Biocontainment Core: Extending the required biosafety training to a personalized curriculum including theoretical and hands-on biocontainment training, understanding the mechanical and regulatory requirements of a BSL3/ABSL3, coaching on how to develop biosafety protocols, and working through risk assessments from the perspective of a Biosafety Officer. Research Imaging Core: Providing theoretical and hands-on training from single cell imaging (confocal microscopy, cytometry, live cell imaging, single cell RNAseq) through to whole body imaging in mice (IVIS) and Non-human primates (NHP) (PET/CT) within large, fully outfitted BSL3/ABSL3 facilities. Animal Model Core: Implementing a training program to introduce all IN-TRAC participants to the regulatory requirements for working with rodents and NHPs, how to develop a robust experimental protocol, how to write an IACUC protocol, and hands-on animal handling and experimental procedures. Clinical Research & Patient Care Core: Introducing IN-TRAC participants to TB patient care at the only free-standing TB hospital in the US (Texas Center of Infectious Diseases) that manages some of the most challenging cases of TB nationally. Partnering with this will be a clinical research experience at the US- Mexico border, to experience TB studies in under-served and under-resourced communities.

德克萨斯州 BIOMED IN-TRAC 总体摘要德克萨斯生物医学研究中心跨学科 NexGen 结核病研究进展中心 (IN-TRAC) 研究所（德克萨斯生物医学）将吸引下一代多元化研究人员参与结核病 (TB) 研究领域，并将他们培养成具有多学科技能和实际经验的独立研究人员临床结核病。 IN-TRAC 的产品将是选择从事一些最具挑战性的研究的研究人员以及结核病相关的转化问题，并且跨学科并在以下框架内发挥作用：高度协作的研究。这将通过 6 个相互关联的核心来实现。行政核心： IN-TRAC 管理和监督的中心枢纽，负责行政和科学事务领导;协调核心、研究人员和 NIH/NIAID 项目工作人员之间的沟通，提供一个组织结构来优化跨学科合作和互动核心以及不同的 IN-TRAC 参与者群体。发展核心：全职业监管开发规划和课程，定制实习生和临床经验为每个 IN-TRAC 参与者提供实习机会，以及 IN-TRAC 试点资助计划的管理。生物安全和生物防护核心：将所需的生物安全培训扩展到个性化课程包括理论和实践生物防护培训，了解机械和监管 BSL3/ABSL3 的要求，指导如何制定生物安全协议以及应对风险从生物安全官员的角度进行评估。研究成像核心：提供理论和单细胞成像实践培训（共聚焦显微镜、细胞计数、活细胞成像、单细胞 RNAseq）到小鼠 (IVIS) 和非人类灵长类动物 (NHP) (NHP) 的全身成像（PET/CT）配备 BSL3/ABSL3 设施。动物模型核心：实施培训计划以介绍所有 IN-TRAC 参与者了解与啮齿动物和 NHP 合作的监管要求，如何开发强大的实验方案、如何编写 IACUC 方案以及实际操作动物处理和实验程序。临床研究和患者护理核心：向 IN-TRAC 参与者介绍结核病患者护理美国唯一一家独立的结核病医院（德克萨斯传染病中心），管理一些全国最具挑战性的结核病病例。与此合作将是在美国的临床研究经验- 墨西哥边境，在服务不足和资源匮乏的社区体验结核病研究。