Retinal vessel measurements as clinically useful predictors in veterans

视网膜血管测量作为退伍军人临床有用的预测因子

• 批准号: 8974192
• 负责人: Michael David Abramoff
• 金额: --
• 依托单位: IOWA CITY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8974192
• 关键词: Biological Markers; Blindness; Blood Pressure; Caliber; Caring; Clinical; Color; Complications of Diabetes Mellitus; Development; Diabetes Mellitus; Diabetic Retinopathy; Diagnosis; Early Intervention; Fundus; Future; Goals; Hypertension; Image; Image Analysis; International; Manuals; Measurement; Measures; Methods; Patients; Photography; Pilot Projects; Population; Population Study; Prevention; Retinal; Retinal Diseases; Risk; Risk Factors; Severities; Source; Time; Venous; Veterans; Weight; Width; diabetic; diet and exercise; high risk; improved; macular edema; mortality; novel; predictive marker; programs; retina blood vessel structure; screening; tool

DESCRIPTION (provided by applicant): Background: We hypothesize that retinal vessel derived biomarkers, obtained using our automated, precise, fast, novel tool for measuring retinal vessels in retinal images can identify veterans at increased risk for diabetic retinopathy and hypertension, before any overt signs of retinopathy or increased blood pressure have become apparent. Population studies have shown that changes in arterial and venous diameter are associated with future development of these complications. Purpose: Determine the potential utility of retinal vessel derived biomarkers, from color fundus photographs, as a non-invasive independent risk factor for diabetic retinopathy (DR) and hypertension in veterans with diabetes. Methods: Aim 1. We will evaluate automatically derived retinal vessel parameters (arterial and retinal vessel width and branch relationships) as an early biomarker for future development of hypertension no less than 2 years later, with normal current normal blood pressure. We will compare this biomarker in retinal images from 500 veterans with diabetes, all of whom did not have hypertension at the time of imaging, for those who were and were not diagnosed with hypertension no more than 3 years later. Aim 2. To evaluate automatically derived retinal vessel parameters as an early biomarker for the risk for development of diabetic retinopathy (defined as transition from less than moderate retinopathy AND no apparent macular edema according to the International Clinical Diabetic Retinopathy and Diabetic Macular Edema Severity Scale) in at risk veterans with diabetes. We will compare this biomarker in retinal images from a population of 4000 veterans with diabetes, currently without DR, ~10% of who developed retinopathy no less than two years later while the remainder did not.

描述（由申请人提供）： 背景：我们假设，使用我们自动化、精确、快速、新颖的工具测量视网膜图像中的视网膜血管获得的视网膜血管衍生生物标志物，可以在出现任何明显的视网膜病变或血压升高迹象之前识别糖尿病视网膜病变和高血压风险增加的退伍军人已变得显而易见。人群研究表明，动脉和静脉直径的变化与这些并发症的未来发展相关。 目的：确定彩色眼底照片中视网膜血管衍生生物标志物作为糖尿病退伍军人糖尿病视网膜病变（DR）和高血压的非侵入性独立危险因素的潜在效用。 方法： 目标 1. 我们将评估自动导出的视网膜血管参数（动脉和视网膜血管宽度和分支关系），作为至少 2 年后在当前血压正常的情况下未来发展为高血压的早期生物标志物。我们将比较 500 名患有糖尿病的退伍军人的视网膜图像中的生物标志物，这些退伍军人在成像时都没有高血压，与 3 年后诊断为高血压和未诊断为高血压的人相比。 目标 2. 评估自动导出的视网膜血管参数，作为糖尿病视网膜病变发生风险的早期生物标志物（根据国际临床糖尿病视网膜病变和糖尿病黄斑水肿严重程度量表，定义为从低于中度的视网膜病变转变且无明显黄斑水肿）患有糖尿病的高危退伍军人。我们将比较 4000 名患有糖尿病的退伍军人的视网膜图像中的生物标志物，这些退伍军人目前没有 DR，其中约 10% 的人在至少两年后出现视网膜病变，而其余的则没有。