Focal Structure-Function Relationships in Macular Layers from 3D Spectral OCT

3D 光谱 OCT 黄斑层的焦点结构-功能关系

• 批准号: 7729130
• 负责人: Michael David Abramoff
• 金额: $ 35.85万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7729130
• 关键词: 3-Dimensional; Address; Adherence; Age; Age Distribution; Age-Years; Anatomy; Anterior; Anterior Ischemic Optic Neuropathy; Axon; Biometry; Burn injury; Characteristics; Clinical; Collaborations; Data; Data Analyses; Devices; Enrollment; Environment; Eye; Frequencies; Glaucoma; Image; Image Analysis; Imaging Device; Knowledge; Link; Location; Measures; Medical Imaging; Methods; Monitor; Morphology; Neuropathy; Ophthalmologist; Ophthalmology; Optical Coherence Tomography; Papillary; Patients; Perimetry; Productivity; Property; Protocols documentation; Qualifying; Reproducibility; Research; Research Personnel; Retina; Retinal; Retinal Diseases; Retinal Ganglion Cells; Structural Models; Structure; Structure-Activity Relationship; Study Subject; Testing; Texture; Thick; Three-Dimensional Image; Three-dimensional analysis; Tissues; Vision; Visual; Visual Fields; Work; age difference; base; central visual field; design; disease diagnosis; experience; functional status; ganglion cell; imaging Segmentation; in vivo; indexing; macula; member; novel strategies; optic nerve disorder; patient oriented research; predictive modeling; public health relevance; relating to nervous system; retinal nerve fiber layer

DESCRIPTION (provided by applicant): This proposal seeks to elucidate the structure-function relationships between visual field threshold sensitivity and the structural features of the retinal layers. The study will address which structural properties of the layers of the macula - obtained from three-dimensional image analysis of spectral domain optical coherence tomography (3-D OCT) - are associated with visual sensitivity, a measure of function. Specifically, we will investigate how structural measures of localized columnar regions of the macula, including layer thickness and texture, are associated with the threshold sensitivity of those macular columns measured at corresponding locations in the central 10 degrees with 10-2 perimetry. The project is driven by an important clinical problem - the poor reliability and reproducibility of the visual field as a measure of irreversible damage to the retinal ganglion cells and their axons in optic neuropathies including glaucoma. If the expected associations are confirmed by 3-D image analysis of spectral domain OCT of the macular layers, the new approach has the potential to become an objective and reproducible addition to the functional assessment of the status of damage. The overriding hypothesis motivating the proposed research is that macular visual sensitivity can be predicted from macular structure and texture properties as imaged and quantified by comprehensive analysis of 3-D spectral-domain OCT. We have identified the following specific aims: Aim 1: Refine and validate our existing method of segmenting retinal layers from 3-D spectral OCT images; derive global and focal structural indices, such as thickness and texture, of each retinal layer in the peripapillary and the macular regions of the retina in normal eyes and in eyes with central visual field damage from glaucoma and anterior ischemic optic neuropathy. Aim 2: Determine how the structural indices derived from the retinal ganglion cell and other intraretinal layers in the macula correlate with the thickness of the corresponding ganglion cell axons in the retinal nerve fiber layer. This will be demonstrated in normal eyes and in eyes with a wide range of macular sensitivity loss from glaucoma and anterior ischemic optic neuropathy. Aim 3: Model the structural-functional relationships in the macula by comparing and registering visual sensitivity at 68 locations (Humphrey 10-2 test averaged over 3 repeats) with their corresponding structural indices of the segmented layers. Derive a predictive model of function from structural properties of the macular layers in the same set of normal and damaged eyes used in Aim 2. The work will be performed in in-vivo acquired 3-D OCT images accompanied by visual field sensitivity test data from 30 normal, 5 glaucoma, and 20 unilateral anterior ischemic optic neuropathy subjects. PUBLIC HEALTH RELEVANCE: Three dimensional spectral OCT imaging provides a wealth of information about the morphology and tissue characteristics of retinal layers. We propose to study structural and functional relationships of the macular intraretinal layers using this new 3-D OCT imaging device. This study has potentially important consequences for glaucoma, anterior ischemic neural neuropathy, and other retinal disease diagnosis and treatment.

描述（由申请人提供）：该提案旨在阐明视野阈值灵敏度与视网膜层结构特征之间的结构功能关系。该研究将探讨黄斑层的哪些结构特性（通过谱域光学相干断层扫描（3-D OCT）的三维图像分析获得）与视觉灵敏度（功能测量）相关。具体来说，我们将研究黄斑局部柱状区域的结构测量（包括层厚度和纹理）如何与使用 10-2 视野检查在中央 10 度相应位置测量的黄斑柱的阈值敏感性相关。该项目是由一个重要的临床问题驱动的——作为衡量青光眼等视神经病变中视网膜神经节细胞及其轴突不可逆损伤的指标，视野的可靠性和再现性较差。如果预期的关联通过黄斑层谱域 OCT 的 3D 图像分析得到证实，那么新方法有可能成为损伤状态功能评估的客观且可重复的补充。推动本研究的首要假设是，通过 3D 频域 OCT 的综合分析，可以根据成像和量化的黄斑结构和纹理特性来预测黄斑视觉敏感性。我们确定了以下具体目标： 目标 1：完善并验证我们现有的从 3-D 光谱 OCT 图像中分割视网膜层的方法；得出正常眼和因青光眼和前部缺血性视神经病变导致中央视野损伤的眼的视乳头周围和视网膜黄斑区域的每个视网膜层的整体和焦点结构指数，例如厚度和纹理。目标 2：确定黄斑中视网膜神经节细胞和其他视网膜内层的结构指数如何与视网膜神经纤维层中相应神经节细胞轴突的厚度相关。这将在正常眼睛和因青光眼和前部缺血性视神经病变而导致黄斑敏感性大范围丧失的眼睛中得到证实。目标 3：通过比较和记录 68 个位置的视觉敏感度（Humphrey 10-2 测试平均超过 3 次重复）与其相应的分段层结构指数，对黄斑中的结构功能关系进行建模。根据目标 2 中使用的同一组正常和受损眼睛的黄斑层结构特性推导功能预测模型。这项工作将在体内采集的 3-D OCT 图像中进行，并附有来自30 名正常受试者、5 名青光眼受试者和 20 名单侧前部缺血性视神经病变受试者。公共健康相关性：三维光谱 OCT 成像提供了有关视网膜层形态和组织特征的丰富信息。我们建议使用这种新型 3D OCT 成像设备研究黄斑视网膜内层的结构和功能关系。这项研究对青光眼、前部缺血性神经病和其他视网膜疾病的诊断和治疗具有潜在的重要影响。