GUMC Zebrafish Shared Resource Aquatic Habitat Modernization Project

GUMC斑马鱼共享资源水生栖息地现代化项目

• 批准号: 10734150
• 负责人: ERIC GLASGOW
• 金额: $ 31.73万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2024-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10734150
• 关键词: Academic Medical Centers; Aging; Animal Experimentation; Animals; Award; Biological Models; Biomedical Research; Breeding; Cancer Model; Comprehensive Cancer Center; Consult; Dedications; Developmental Biology; Dose; Education; Education and Outreach; Electricity; Embryo; Ensure; Equipment; Event; Expenditure; Film; Filtration; Fishes; Floor; Funding; Goals; Grant; Habitats; Health; Health Services Accessibility; Housing; Image; Immunology; Institution; International; Knowledge; Life Support Systems; Longevity; Maintenance; Malignant Neoplasms; Medical Research; Mission; Modeling; Modernization; Monitor; NCI Center for Cancer Research; Neurobiology; Neurologic; Neurosciences; Oncology; Organism; Persons; Phenotype; Plumbing; Positioning Attribute; Printing; Pump; R24; Reproducibility; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Rotation; Services; Site; Source; Standardization; Stress; Students; System; Technology; Training; Transgenic Organisms; United States National Institutes of Health; Universities; Update; Water; Work; Workload; Zebrafish; career; community center; design; experimental study; improved; medical schools; member; model organism; mutant; oocyte quality; operation; outreach; professor; programs; screening; sensor; wasting; water quality; wireless fidelity

Abstract: The Georgetown University Medical Center (GUMC) Zebrafish Shared Resource (ZSR), a member of the Lombardi Comprehensive Cancer Center (LCCC) Research Consortium, provides expertise and ready access to zebrafish as a model for biomedical research to the GUMC community. Under the direction of Dr. Eric Glasgow, Assistant Professor of Oncology, and with assistance from Dr. Matthew Swift, the ZSR has provided research services and support for dozens of investigators, both internal and external, to incorporate zebrafish models into their research. The ZSR was the first of its kind to offer full-service access to zebrafish models anywhere and is an essential part of GUMC fulfilling its mission to offer a full range of state-of-the-art research services expected of a top national academic medical center. The current aquatic life support system utilized by the facility was built in 2004. Due to maintenance by and expertise of the ZSR director, the facility has far outlasted its projected useful lifespan, as well as that of the company that built it, Aquatic Habitats. A complete upgrade of the current system is necessary in order to maintain and enhance the efficiency and standardization of our zebrafish husbandry. A modern, technologically advanced aquatic animal system equipped with water quality assessment sensors will increase the housing capacity, doubling the number fish; decrease the husbandry workload increasing operational efficiencies; increase sustainability by saving energy, water, and materials; standardize husbandry conditions; and improve the consistency and quality of egg laying. These improvements will increase research capacity of the ZSR, as well as improving the rigor, reproducibility, and translatability of our zebrafish-based research. We are applying for this R24 grant in order to purchase a new aquatic system that will accomplish these goals and allow GUMC to expand on its position as one of the leaders in utilizing the zebrafish model for research into oncology, immunology, neuroscience, and developmental biology. If awarded, the grant will cover necessary expenditures related to the purchase of the new system and required support equipment.

摘要：乔治敦大学医学中心（GUMC）斑马鱼共享资源（ZSR），成员 伦巴第综合癌症中心（LCCC）研究联盟的专业知识和准备就绪 进入斑马鱼作为向GUMC社区进行生物医学研究的模型。在博士的指导下 肿瘤学助理教授Eric Glasgow，在Matthew Swift博士的协助下，ZSR有 为数十名内部和外部调查人员提供了研究服务和支持 斑马鱼模型进入他们的研究。 ZSR是第一个提供全方位服务访问斑马鱼的人 在任何地方模型，是GUMC履行其使命的重要组成部分，以提供全面的最先进 研究服务期望是国家顶级学术医学中心。当前的水生生命支持系统 该设施使用的设施建于2004年。由于ZSR主管的维护和专业知识，该设施 远远超过了预计有用的寿命以及建造它的水生栖息地的寿命。一个 为了维持和提高效率和 斑马鱼饲养的标准化。现代技术先进的水生动物系统 配备水质评估传感器将增加住房能力，使数量增加一倍。 减少饲养工作量提高运营效率；通过节省能源来提高可持续性 水和材料；标准化饲养条件；并提高产卵的一致性和质量。 这些改进将提高ZSR的研究能力，并提高严格，可重复性， 以及我们基于斑马鱼的研究的翻译性。我们正在申请此R24赠款，以购买 新的水上系统将实现这些目标，并允许GUMC扩大其作为其中之一的地位 领导者利用斑马鱼模型进行肿瘤学，免疫学，神经科学和 发展生物学。如果授予，赠款将涵盖与购买有关的必要支出 新系统和所需的支持设备。