NATIONAL NEUROLOGICAL AIDS BANK

国家神经艾滋病银行

基本信息

批准号：
9924028
负责人：
ELYSE J SINGER
金额：
$ 25.76万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-05-10 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9924028
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Adverse effects Age Aging Aliquot Anti-Retroviral Agents Autopsy Biological Blood specimen Central Nervous System Diseases Central Nervous System Infections Cerebrospinal Fluid Collaborations Communities Data Data Collection Data Coordinating Center Databases Diabetes Mellitus Enrollment Equipment and supply inventories Formalin Freezing Future Geography Goals HIV HIV Infections HIV Seronegativity HIV-1 Health Human Hyperlipidemia Immune Individual Inflammation Inflammatory Response Knowledge Laboratories Life Liquid substance Long-Term Effects Longevity Medical Mental disorders Methodology National NeuroAids Tissue Consortium Nervous system structure Neuraxis Neurocognitive Deficit Neurologic Neuropathogenesis Neuropsychology Paraffin Embedding Participant Pathogenicity Patients Penetration Peripheral Peripheral Nervous System Peripheral Nervous System Diseases Persons Population Procedures Protocols documentation Provider Publications Research Research Personnel Resources Sampling Site Slide Source Specimen Standardization Time Tissue Donors Tissue Embedding Tissue Harvesting Tissues United States National Institutes of Health Vascular Diseases Viral Viral reservoir Work antiretroviral therapy biobank clinical practice clinical research site cohort comorbidity data exchange data sharing data standards high risk human tissue improved interest member mortality risk nervous system disorder neuroAIDS neurotoxic peer programs quality assurance recruit research study restoration sample collection

项目摘要

Project Summary/Abstract Human immunodeficiency virus (HIV) remains a global threat to human health and an important cause of neurologic and psychiatric disorders, despite advances in longevity due to the use of antiretroviral therapy (ART). ART suppresses HIV replication and allows for partial immune restoration, but may fail to achieve adequate penetration of the central nervous system (CNS). Currently, ART does not eliminate latent HIV, does not clear viral reservoirs, and does not normalize the inflammatory response. Further, some ART may have neurotoxic effects. For these reasons, HIV-associated disorders of the CNS and peripheral nervous system (PNS) have persisted and evolved despite the use of ART in the aging HIV+ population. In order to cure HIV infection of the CNS and to elucidate the pathogenic mechanisms of CNS and PNS disease in ART-treated patients, as well as to continue ongoing studies of aging and HIV co- morbid conditions, NeuroAIDS investigators require a continuous and reliable source of well- characterized human tissues, fluids, and data. These invaluable resources are provided by the National Neurological AIDS Bank (NNAB), a member of the National NeuroAIDS Tissue Consortium (NNTC). Over the past 19 years, the NNAB has enrolled 806 participants, and currently follows a cohort of 171 active participants who have agreed to be tissue donors. Most of our donors have received serial, pre-mortem medical, neurologic, neuropsychologic and laboratory examinations. NNAB has also performed 259 tissue harvests of cohort members. Over the past 5 years, the NNAB has distributed 3,766 frozen tissue specimens, 853 fixed tissue specimens, 23,007 formalin fixed paraffin embedded tissue slides and 3,065 aliquots of fluids to NNTC-approved, qualified investigators. The NNTC is a consortium of 4 geographically dispersed clinical sites and a Data Coordinating Center (DCC). Over the past 5 years, NNTC has collectively fulfilled 123 specimen requests that generated 128 publications. The NNAB actively collaborates with the other NNTC clinical sites and the DCC to develop and maintain standard study protocols, to transfer data to the DCC, to review investigator requests for NNTC resources, and to allocate such resources in a fair and timely fashion. The NNTC works with the DCC to insure we maintain an accurate specimen inventory, and to support the harmonized central NNTC database. The NNAB looks forward to working with our participants, our colleagues, and our requesters for another 5 years to expand and develop this priceless and indispensable scientific resource.

项目概要/摘要人类免疫缺陷病毒（HIV）仍然是对人类健康的全球性威胁，也是导致人类健康的重要原因。尽管由于使用抗逆转录病毒疗法（ART）而延长了寿命，但神经和精神疾病仍然存在。 ART 抑制 HIV 复制并允许部分免疫恢复，但可能无法达到足够的效果中枢神经系统（CNS）的渗透。目前，ART 并不能消除潜伏的 HIV，也不能清除病毒储存库，并且不能使炎症反应正常化。此外，某些 ART 可能具有神经毒性影响。由于这些原因，HIV 相关的中枢神经系统和周围神经系统 (PNS) 疾病已尽管在老龄化的艾滋病毒+人群中使用了抗逆转录病毒治疗，但这种情况仍然持续存在并不断发展。为了治愈中枢神经系统HIV感染并阐明中枢神经系统和中枢神经系统的致病机制接受 ART 治疗的患者中的 PNS 疾病，以及继续正在进行的衰老和 HIV 共同研究为了应对疾病状况，神经艾滋病研究人员需要持续可靠的良好来源表征人体组织、体液和数据。这些宝贵的资源由国家神经艾滋病银行 (NNAB)，国家神经艾滋病组织联盟成员 (NNTC)。在过去的 19 年里，NNAB 已招募了 806 名参与者，目前遵循由 171 名同意成为组织捐赠者的活跃参与者组成的队列。我们的大多数捐助者都有接受了一系列的尸前医学、神经病学、神经心理学和实验室检查。 NNAB 还对队列成员进行了 259 例组织采集。过去 5 年里，国家环境局已分发冷冻组织标本3,766份、固定组织标本853份、福尔马林固定石蜡23,007份向 NNTC 批准的合格研究人员提供包埋的组织载玻片和 3,065 份液体。 NNTC 是一个由 4 个地理位置分散的临床中心和一个数据协调中心组成的联盟（DCC）。在过去的 5 年里，NNTC 总共完成了 123 个样本请求，产生了 128 个样本。出版物。 NNAB 积极与其他 NNTC 临床中心和 DCC 合作开发并维护标准研究方案、将数据传输至 DCC、审查研究者的请求 NNTC 资源，并公平、及时地分配这些资源。 NNTC 与 DCC 确保我们保持准确的样本库存，并支持统一的中央 NNTC 数据库。 NNAB 期待与我们的参与者、同事和请求者合作再用五年时间来扩大和发展这一无价且不可或缺的科学资源。