NATIONAL NEUROLOGICAL AIDS BANK

国家神经艾滋病银行

• 批准号: 10355525
• 负责人: ELYSE J SINGER
• 金额: $ 141.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-10 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10355525
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adverse effects; Age; Aging; Aliquot; Anti-Retroviral Agents; Autopsy; Biological; Blood specimen; Central Nervous System Diseases; Central Nervous System Infections; Cerebrospinal Fluid; Collaborations; Communities; Data; Data Collection; Data Coordinating Center; Databases; Diabetes Mellitus; Enrollment; Equipment and supply inventories; Formalin; Freezing; Future; Geography; Goals; HIV; HIV Infections; HIV Seronegativity; HIV-1; Health; Human; Hyperlipidemia; Immune; Individual; Inflammation; Inflammatory Response; Knowledge; Laboratories; Life; Liquid substance; Long-Term Effects; Longevity; Medical; Mental disorders; Methodology; National NeuroAids Tissue Consortium; Nervous system structure; Neuraxis; Neurocognitive Deficit; Neurologic; Neuropathogenesis; Neuropsychology; Paraffin Embedding; Participant; Pathogenicity; Patients; Penetration; Peripheral; Peripheral Nervous System; Peripheral Nervous System Diseases; Persons; Population; Procedures; Protocols documentation; Provider; Publications; Research; Research Personnel; Resources; Sampling; Site; Slide; Source; Specimen; Standardization; Time; Tissue Donors; Tissue Embedding; Tissue Harvesting; Tissues; United States National Institutes of Health; Vascular Diseases; Viral; Viral reservoir; Work; antiretroviral therapy; biobank; clinical practice; clinical research site; cohort; comorbidity; data exchange; data sharing; data standards; high risk; human tissue; improved; interest; member; mortality risk; nervous system disorder; neuroAIDS; neurotoxic; peer; programs; quality assurance; recruit; research study; restoration; sample collection

Project Summary/Abstract Human immunodeficiency virus (HIV) remains a global threat to human health and an important cause of neurologic and psychiatric disorders, despite advances in longevity due to the use of antiretroviral therapy (ART). ART suppresses HIV replication and allows for partial immune restoration, but may fail to achieve adequate penetration of the central nervous system (CNS). Currently, ART does not eliminate latent HIV, does not clear viral reservoirs, and does not normalize the inflammatory response. Further, some ART may have neurotoxic effects. For these reasons, HIV-associated disorders of the CNS and peripheral nervous system (PNS) have persisted and evolved despite the use of ART in the aging HIV+ population. In order to cure HIV infection of the CNS and to elucidate the pathogenic mechanisms of CNS and PNS disease in ART-treated patients, as well as to continue ongoing studies of aging and HIV co- morbid conditions, NeuroAIDS investigators require a continuous and reliable source of well- characterized human tissues, fluids, and data. These invaluable resources are provided by the National Neurological AIDS Bank (NNAB), a member of the National NeuroAIDS Tissue Consortium (NNTC). Over the past 19 years, the NNAB has enrolled 806 participants, and currently follows a cohort of 171 active participants who have agreed to be tissue donors. Most of our donors have received serial, pre-mortem medical, neurologic, neuropsychologic and laboratory examinations. NNAB has also performed 259 tissue harvests of cohort members. Over the past 5 years, the NNAB has distributed 3,766 frozen tissue specimens, 853 fixed tissue specimens, 23,007 formalin fixed paraffin embedded tissue slides and 3,065 aliquots of fluids to NNTC-approved, qualified investigators. The NNTC is a consortium of 4 geographically dispersed clinical sites and a Data Coordinating Center (DCC). Over the past 5 years, NNTC has collectively fulfilled 123 specimen requests that generated 128 publications. The NNAB actively collaborates with the other NNTC clinical sites and the DCC to develop and maintain standard study protocols, to transfer data to the DCC, to review investigator requests for NNTC resources, and to allocate such resources in a fair and timely fashion. The NNTC works with the DCC to insure we maintain an accurate specimen inventory, and to support the harmonized central NNTC database. The NNAB looks forward to working with our participants, our colleagues, and our requesters for another 5 years to expand and develop this priceless and indispensable scientific resource.

项目摘要/摘要 人类免疫缺陷病毒（HIV）仍然是对人类健康的全球威胁，也是 尽管使用了抗逆转录病毒疗法（ART），但神经系统和精神疾病的长寿进步。 艺术抑制艾滋病毒复制并允许部分免疫修复，但可能无法实现足够的 中枢神经系统（CNS）的渗透。目前，艺术没有消除潜在的艾滋病毒，尚未清楚 病毒储层，不会使炎症反应正常化。此外，某些艺术可能具有神经毒性 效果。由于这些原因，中枢神经系统和周围神经系统（PNS）的HIV相关疾病具有 尽管在衰老的艾滋病毒+人群中使用了艺术，但仍在持续和进化。 为了治愈中枢神经系统的HIV感染，并阐明了中枢神经系统的致病机制 经过艺术治疗的患者的PNS病，以及继续进行衰老和HIV共同研究 病态状况，神经辅助调查人员需要一个持续可靠的良好来源 人类组织，流体和数据表征。这些宝贵的资源由 国家神经辅助银行国家神经艾滋病银行（NNAB），国家神经辅助组织的成员 （NNTC）。在过去的19年中，NNAB已注册806名参与者，目前遵循 同意成为组织捐献者的171名活跃参与者的队列。我们的大多数捐助者都有 接受了串行，验尸医学，神经系统，神经心理学和实验室检查。 NNAB还进行了259次组织收获的队列成员。在过去的5年中，NNAB 已经分布了3,766个冷冻组织样品，853个固定组织样品，23,007福尔马林固定石蜡 嵌入的组织载玻片和3,065个等分试样与NNTC批准的合格研究者。 NNTC是一个由4个地理分散的临床站点和一个数据协调中心的财团 （DCC）。在过去的5年中，NNTC共同满足了128个标本请求128的要求 出版物。 NNAB与其他NNTC临床站点和DCC积极合作以开发 并维护标准研究方案，以将数据传输到DCC，以审查研究者的要求 NNTC资源，并以公平而及时的方式分配此类资源。 NNTC与 DCC确保我们保持准确的标本清单，并支持协调的中央NNTC 数据库。 NNAB期待与我们的参与者，我们的同事和我们的请求者合作 再过5年，可以扩展和发展这种无价和必不可少的科学资源。