National Neurological AIDS Bank

国家神经艾滋病银行

• 批准号: 8539923
• 负责人: ELYSE J SINGER
• 金额: $ 118.25万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-10 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8539923
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Address; Age; Aging; Area; Autopsy; Award; Back; Behavioral; Blood; California; Case Report Form; Cerebrospinal Fluid; Climacteric; Collaborations; Collection; Data; Data Collection; Data Coordinating Center; Databases; Development; Dictionary; Disease; Educational Background; Enrollment; Ensure; Epidemic; Equipment and supply inventories; Evolution; Failure; Funding; Future; Gender; Goals; HIV; HIV-1; Highly Active Antiretroviral Therapy; Human; Individual; Language; Life; Linguistics; Liquid substance; Location; Methods; Neurocognitive; Neurologic; Neuropathogenesis; Participant; Patients; Peripheral; Persons; Population; Positioning Attribute; Principal Investigator; Procedures; Process; Quality Control; Recruitment Activity; Regimen; Research; Research Personnel; Research Project Grants; Research Support; Resources; Review Committee; Science; Site; Source; Specific qualifier value; Specimen; Standardization; Tissues; United States National Institutes of Health; Update; Viral; Work; abstracting; age related; base; clinical research site; cohort; data acquisition; high risk; human tissue; improved; meetings; mortality; nervous system disorder; pandemic disease; public health relevance; quality assurance; racial and ethnic; sample collection; tissue resource; trend

DESCRIPTION (provided by applicant): Human immunodeficiency virus type-1 (HIV) remains a near-inexorable cause of neurological and behavioral disease (NeuroAIDS) despite the prolonged survival of many HIV-infected (HIV+) individuals associated with use of highly active antiretroviral therapy (HAART). The failure of current HAART regimens to eliminate HIV from the CNS has led to the development of a protected viral reservoir, new forms of HIV associated neurocognitive disorder (HAND), and increasing numbers of age-related neurological disorders in older HIV+ persons. In order to address these evolving issues, investigators require well-characterized human CNS tissues and fluids from well-characterized cohorts. Thus, the human tissues, fluids, and data provided by the National Neurological AIDS Bank (NNAB) and National NeuroAIDS Tissue Consortium (NNTC), remain essential for investigators to perform studies that will benefit HIV+ patients. To date, the NNAB has successfully recruited 719 participants of diverse racial, ethnic, linguistic, and educational backgrounds and both genders. We follow a living cohort of 184 participants, and we have performed 228 autopsies, of which 86% of descendants had pre-mortem study data. We have supplied 216 requests for tissues and data, and we have generated numerous independently funded research projects at UCLA that enhance our resources and further the science of NeuroAIDS. We actively collaborate with the other NNTC clinical sites and the NNTC Data Coordinating Committee (DCC) to maintain an up-to-date central database and specimen inventory and to fulfill requests for tissues, fluids, and data. Since the advent of the NNTC initiative, our participants have lived longer than was anticipated. This has engendered new problems and has forced us to be scientifically nimble and to rapidly adjust to the changing face of the HIV pandemic. The NNAB, adapting in turn, has successful research projects and collaborations that interact with the Bank and advance the very field of NeuroAIDS. We look forward to continuing our work with our colleagues at the other clinical sites, the DCC, and the NIH, on this important and for many, life- changing project.

描述（由申请人提供）：尽管许多HIV感染（HIV+）个体长期存在与使用高度活性抗逆转录病毒疗法（HAART）相关的许多HIV（HIV+）个体的生存率延长，但人类免疫缺陷病毒类型1型（HIV）仍然是神经系统和行为疾病（神经辅助）的几乎可感染的原因。当前HAART方案从中枢神经系统中消除HIV的失败导致了受保护的病毒储量的发展，新形式的HIV相关神经认知障碍（HARD）以及年龄较大的HIV+患者与年龄相关的神经系统疾病的数量越来越多。为了解决这些不断发展的问题，研究人员需要特征良好的人类中枢神经系统组织和特征良好的人群的流体。因此，国家神经系统艾滋病库（NNAB）和国家神经辅助组织（NNTC）提供的人体组织，流体和数据对于研究人员进行将使HIV+患者受益的研究仍然至关重要。迄今为止，NNAB已成功招募了719名种族，种族，语言和教育背景以及两种性别的参与者。我们遵循184名参与者的活生生队列，我们​​进行了228次尸检，其中86％的后代具有验尸前研究数据。我们已经提供了216个有关组织和数据的请求，并且在UCLA中生成了许多独立资助的研究项目，从而增强了我们的资源并进一步发展了神经助长的科学。我们与其他NNTC临床站点和NNTC数据协调委员会（DCC）积极合作，以维持最新的中央数据库和标本清单，并满足有关组织，流体和数据的请求。自NNTC倡议的出现以来，我们的参与者的寿命比预期的要长。这引发了新问题，并迫使我们在科学上敏捷，并迅速适应艾滋病毒大流行的面孔。 NNAB依次适应了成功的研究项目和合作，这些项​​目与银行互动并推进了神经辅助的领域。我们期待在其他临床网站，DCC和NIH上继续与同事继续我们的工作，这是对许多重要的，改变生活的项目。