National Neurological AIDS Bank

国家神经艾滋病银行

• 批准号: 8539923
• 负责人: ELYSE J SINGER
• 金额: $ 118.25万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-10 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8539923
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Address; Age; Aging; Area; Autopsy; Award; Back; Behavioral; Blood; California; Case Report Form; Cerebrospinal Fluid; Climacteric; Collaborations; Collection; Data; Data Collection; Data Coordinating Center; Databases; Development; Dictionary; Disease; Educational Background; Enrollment; Ensure; Epidemic; Equipment and supply inventories; Evolution; Failure; Funding; Future; Gender; Goals; HIV; HIV-1; Highly Active Antiretroviral Therapy; Human; Individual; Language; Life; Linguistics; Liquid substance; Location; Methods; Neurocognitive; Neurologic; Neuropathogenesis; Participant; Patients; Peripheral; Persons; Population; Positioning Attribute; Principal Investigator; Procedures; Process; Quality Control; Recruitment Activity; Regimen; Research; Research Personnel; Research Project Grants; Research Support; Resources; Review Committee; Science; Site; Source; Specific qualifier value; Specimen; Standardization; Tissues; United States National Institutes of Health; Update; Viral; Work; abstracting; age related; base; clinical research site; cohort; data acquisition; high risk; human tissue; improved; meetings; mortality; nervous system disorder; pandemic disease; public health relevance; quality assurance; racial and ethnic; sample collection; tissue resource; trend

DESCRIPTION (provided by applicant): Human immunodeficiency virus type-1 (HIV) remains a near-inexorable cause of neurological and behavioral disease (NeuroAIDS) despite the prolonged survival of many HIV-infected (HIV+) individuals associated with use of highly active antiretroviral therapy (HAART). The failure of current HAART regimens to eliminate HIV from the CNS has led to the development of a protected viral reservoir, new forms of HIV associated neurocognitive disorder (HAND), and increasing numbers of age-related neurological disorders in older HIV+ persons. In order to address these evolving issues, investigators require well-characterized human CNS tissues and fluids from well-characterized cohorts. Thus, the human tissues, fluids, and data provided by the National Neurological AIDS Bank (NNAB) and National NeuroAIDS Tissue Consortium (NNTC), remain essential for investigators to perform studies that will benefit HIV+ patients. To date, the NNAB has successfully recruited 719 participants of diverse racial, ethnic, linguistic, and educational backgrounds and both genders. We follow a living cohort of 184 participants, and we have performed 228 autopsies, of which 86% of descendants had pre-mortem study data. We have supplied 216 requests for tissues and data, and we have generated numerous independently funded research projects at UCLA that enhance our resources and further the science of NeuroAIDS. We actively collaborate with the other NNTC clinical sites and the NNTC Data Coordinating Committee (DCC) to maintain an up-to-date central database and specimen inventory and to fulfill requests for tissues, fluids, and data. Since the advent of the NNTC initiative, our participants have lived longer than was anticipated. This has engendered new problems and has forced us to be scientifically nimble and to rapidly adjust to the changing face of the HIV pandemic. The NNAB, adapting in turn, has successful research projects and collaborations that interact with the Bank and advance the very field of NeuroAIDS. We look forward to continuing our work with our colleagues at the other clinical sites, the DCC, and the NIH, on this important and for many, life- changing project.

描述（由申请人提供）：尽管许多 HIV 感染者 (HIV+) 因使用高活性抗逆转录病毒药物而得以延长生存期，但 1 型人类免疫缺陷病毒 (HIV) 仍然是神经和行为疾病 (NeuroAIDS) 近乎不可避免的原因。治疗（HAART）。目前的HAART疗法未能消除中枢神经系统中的HIV，导致受保护的病毒库的形成、新形式的HIV相关神经认知障碍(HAND)以及老年HIV阳性者中与年龄相关的神经障碍数量的增加。为了解决这些不断发展的问题，研究人员需要来自特征明确的群体的特征明确的人类中枢神经系统组织和液体。因此，国家神经艾滋病库 (NNAB) 和国家神经艾滋病组织联盟 (NNTC) 提供的人体组织、体液和数据对于研究人员开展造福 HIV+ 患者的研究仍然至关重要。迄今为止，NNAB 已成功招募了 719 名不同种族、民族、语言和教育背景的参与者，不分性别。我们追踪了 184 名参与者的活生生队列，并进行了 228 次尸检，其中 86% 的后代拥有尸检前研究数据。我们已经提供了 216 个组织和数据请求，并且在加州大学洛杉矶分校发起了许多独立资助的研究项目，这些项目增强了我们的资源并进一步推动了神经艾滋病科学的发展。我们积极与其他 NNTC 临床中心和 NNTC 数据协调委员会 (DCC) 合作，维护最新的中央数据库和标本库存，并满足对组织、液体和数据的要求。自从 NNTC 倡议出现以来，我们的参与者的寿命比预期的要长。这产生了新的问题，迫使我们在科学上保持灵活性，并迅速适应艾滋病毒大流行不断变化的面貌。 NNAB 也相应地进行了调整，拥有成功的研究项目和合作，与世行互动并推动 NeuroAIDS 领域的发展。我们期待与其他临床中心、DCC 和 NIH 的同事继续合作，共同开展这一重要且改变许多人生活的项目。