NATIONAL NEUROLOGICAL AIDS BANK

国家神经艾滋病银行

基本信息

批准号：
8363433
负责人：
ELYSE J SINGER
金额：
$ 1.86万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8363433
关键词：
Acquired Immunodeficiency Syndrome Adverse effects Blood Cerebrospinal Fluid Cessation of life Collaborations Communities Consensus Development Diabetes Mellitus Diagnosis Education Epidemic Female Funding Gender Grant HIV HIV therapy Hepatitis C Hepatitis C virus Hypertension Life Longitudinal Studies Los Angeles Magnetic Resonance Spectroscopy Medical Medical center Minority Groups Modeling Monitor National Center for Research Resources Nervous system structure Neurologic Neuropsychology Olives - dietary Organ Pathogenesis Principal Investigator Protocols documentation Psychiatry Qualifying Research Research Infrastructure Research Personnel Resources Source Substance abuse problem Tissue Banks Tissues United States National Institutes of Health Universities University Hospitals Urine Viral Load result cohort computational anatomy cost lipid disorder male member nervous system disorder neuropathology neuropsychological quality assurance racial and ethnic tool

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This application represents the renewal of National Neurological AIDS Bank (NNAB), a member of the National Neuro-AIDS Tissue Consortium (NNTC). NNAB is a longitudinal study of well-characterized subjects with advanced AIDS and HIV-seronegative (HIV-) subjects, who have agreed to have serial neurological and neuropsychological examinations during their life, and to donate blood, urine and cerebrospinal fluid (CSF) during life and their organs and tissues after their death. NNAB collects these tissues and organs and distributes them to qualified investigators for research into the pathogenesis of Neuro-AIDS. NNAB characterizes its cohort using standardized NNTC protocols in Neuromedicine, Neuropsychology, Psychiatry/Substance Abuse, and Neuropathology, to achieve consensus diagnoses that are monitored by the NNTC Quality Assurance Committees. In addition, NNAB independently collects information that is essential to study the association between co-morbid medical conditions, such as Hepatitis C virus (HCV) infection, hypertension, diabetes, lipid disorders, as well as the adverse effects of retroviral therapy and HIV neurological disease. The NNAB cohort is unique because of its diversity, and reflects the gender, ethnic, and racial distribution of AIDS in Los Angeles. NNAB is 85% male and 15% female; over 60% of our cohort is a member of racial and ethnic minorities, 20% are monolingual in Spanish, and 8% have less than 6 years of education. In this renewal, we plan to expand our cohort, utilizing our collaborations among UCLA Medical Center, Olive View-UCLA Medical Center, Charles R. Drew University, and USC University Hospital. NNAB has stimulated the development of independently funded projects studying CSF viral load, HCV and the nervous system, and magnetic resonance spectroscopy (MRS) as a tool for following HIV neurological disease. These projects and the information they generate further enrich the value of our tissue collection. NNAB provides an increasingly important resource that mirrors the changing face of the AIDS epidemic and is capable of adapting as the needs of investigators dictate. NNAB provides an invaluable resource to the NNTC, the scientific community, and people living with AIDS.

该子项目是利用资源的众多研究子项目之一由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持并且子项目的主要研究者可能是由其他来源提供的，包括其他 NIH 来源。子项目可能列出的总成本代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。该申请代表国家神经艾滋病库 (NNAB) 的更新，该银行是国家神经艾滋病组织联盟 (NNTC) 的成员。 NNAB 是一项针对晚期艾滋病患者和 HIV 血清阴性 (HIV-) 受试者的纵向研究，这些受试者同意在其一生中进行一系列神经学和神经心理学检查，并在治疗期间捐献血液、尿液和脑脊液 (CSF)。生命及其死后的器官和组织。 NNAB 收集这些组织和器官，并将其分发给合格的研究人员，用于研究神经艾滋病的发病机制。 NNAB 使用神经医学、神经心理学、精神病学/药物滥用和神经病理学方面的标准化 NNTC 协议来描述其队列，以实现由 NNTC 质量保证委员会监控的共识诊断。此外，NNAB 独立收集对于研究共病医疗状况之间的关联至关重要的信息，例如丙型肝炎病毒 (HCV) 感染、高血压、糖尿病、血脂紊乱，以及逆转录病毒治疗和 HIV 神经系统疾病的不良影响。疾病。 NNAB 队列因其多样性而独一无二，反映了洛杉矶艾滋病的性别、民族和种族分布。 NNAB 中 85% 为男性，15% 为女性；我们的群体中超过 60% 的人是少数种族和族裔成员，20% 的人只会说西班牙语，8% 的人受教育时间少于 6 年。在这次更新中，我们计划利用加州大学洛杉矶分校医学中心、Olive View-加州大学洛杉矶分校医学中心、查尔斯·R·德鲁大学和南加州大学医院之间的合作来扩大我们的队列。 NNAB 刺激了独立资助项目的发展，这些项目研究脑脊液病毒载量、丙型肝炎病毒和神经系统，以及磁共振波谱 (MRS) 作为追踪 HIV 神经系统疾病的工具。这些项目及其产生的信息进一步丰富了我们组织收集的价值。 NNAB 提供了越来越重要的资源，反映了艾滋病流行不断变化的面貌，并且能够根据调查人员的需求进行调整。 NNAB 为 NNTC、科学界和艾滋病患者提供了宝贵的资源。