NATIONAL NEUROLOGICAL AIDS BANK

国家神经艾滋病银行

• 批准号: 8363433
• 负责人: ELYSE J SINGER
• 金额: $ 1.86万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363433
• 关键词: Acquired Immunodeficiency Syndrome; Adverse effects; Blood; Cerebrospinal Fluid; Cessation of life; Collaborations; Communities; Consensus; Development; Diabetes Mellitus; Diagnosis; Education; Epidemic; Female; Funding; Gender; Grant; HIV; HIV therapy; Hepatitis C; Hepatitis C virus; Hypertension; Life; Longitudinal Studies; Los Angeles; Magnetic Resonance Spectroscopy; Medical; Medical center; Minority Groups; Modeling; Monitor; National Center for Research Resources; Nervous system structure; Neurologic; Neuropsychology; Olives - dietary; Organ; Pathogenesis; Principal Investigator; Protocols documentation; Psychiatry; Qualifying; Research; Research Infrastructure; Research Personnel; Resources; Source; Substance abuse problem; Tissue Banks; Tissues; United States National Institutes of Health; Universities; University Hospitals; Urine; Viral Load result; cohort; computational anatomy; cost; lipid disorder; male; member; nervous system disorder; neuropathology; neuropsychological; quality assurance; racial and ethnic; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This application represents the renewal of National Neurological AIDS Bank (NNAB), a member of the National Neuro-AIDS Tissue Consortium (NNTC). NNAB is a longitudinal study of well-characterized subjects with advanced AIDS and HIV-seronegative (HIV-) subjects, who have agreed to have serial neurological and neuropsychological examinations during their life, and to donate blood, urine and cerebrospinal fluid (CSF) during life and their organs and tissues after their death. NNAB collects these tissues and organs and distributes them to qualified investigators for research into the pathogenesis of Neuro-AIDS. NNAB characterizes its cohort using standardized NNTC protocols in Neuromedicine, Neuropsychology, Psychiatry/Substance Abuse, and Neuropathology, to achieve consensus diagnoses that are monitored by the NNTC Quality Assurance Committees. In addition, NNAB independently collects information that is essential to study the association between co-morbid medical conditions, such as Hepatitis C virus (HCV) infection, hypertension, diabetes, lipid disorders, as well as the adverse effects of retroviral therapy and HIV neurological disease. The NNAB cohort is unique because of its diversity, and reflects the gender, ethnic, and racial distribution of AIDS in Los Angeles. NNAB is 85% male and 15% female; over 60% of our cohort is a member of racial and ethnic minorities, 20% are monolingual in Spanish, and 8% have less than 6 years of education. In this renewal, we plan to expand our cohort, utilizing our collaborations among UCLA Medical Center, Olive View-UCLA Medical Center, Charles R. Drew University, and USC University Hospital. NNAB has stimulated the development of independently funded projects studying CSF viral load, HCV and the nervous system, and magnetic resonance spectroscopy (MRS) as a tool for following HIV neurological disease. These projects and the information they generate further enrich the value of our tissue collection. NNAB provides an increasingly important resource that mirrors the changing face of the AIDS epidemic and is capable of adapting as the needs of investigators dictate. NNAB provides an invaluable resource to the NNTC, the scientific community, and people living with AIDS.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该应用代表了国家神经辅助组织组织（NNTC）的成员国家神经艾滋病银行（NNAB）的更新。 NNAB是一项纵向研究，对具有高级辅助药和HIV辅助（HIV-）受试者的特征性受试者，他们同意在他们的生活中进行串行的神经系统和神经心理学检查，并在生命中及其organs及其死后捐赠血液，尿液，尿液，尿液，尿液脊髓液（CSF）。 NNAB收集这些组织和器官，并将其分配给合格的研究人员，以研究神经辅助的发病机理。 NNAB在神经医学，神经心理学，精神病学/药物滥用和神经病理学中使用标准化的NNTC方案来表征其队列，以实现由NNTC质量保证委员会监控的共识诊断。此外，NNAB独立收集有关研究合并症患者（例如丙型肝炎）感染（HCV）感染，高血压，糖尿病，脂质疾病以及逆转录病毒治疗和HIV神经系统疾病的不良影响的信息。 NNAB队列的多样性是独一无二的，并且反映了洛杉矶艾滋病的性别，种族和种族分布。 NNAB是男性85％，女性为15％；我们的队列中有60％以上是种族和少数民族的成员，有20％的西班牙语是单语，而8％的教育少于6年。在此续约中，我们计划利用我们在加州大学洛杉矶分校医疗中心，Olive View-Ucla医学中心，Charles R. Drew University和USC大学医院之间进行合作。 NNAB刺激了研究CSF病毒负荷，HCV和神经系统以及磁共振光谱（MRS）的独立资助项目的发展，作为遵循HIV神经系统疾病的工具。这些项目及其产生的信息进一步丰富了我们组织收集的价值。 NNAB提供了一个越来越重要的资源，可以反映艾滋病流行病的不断变化，并能够按照调查人员的要求来适应。 NNAB为NNTC，科学界和拥有艾滋病的人们提供了宝贵的资源。