California NeuroAIDS Tissue Network

加州神经艾滋病组织网络

• 批准号: 8540465
• 负责人: IGOR GRANT
• 金额: $ 119.59万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540465
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Address; Age-Years; Aging; Aliquot; Anti-Retroviral Agents; Antiviral Agents; Autopsy; Brain; California; Cessation of life; Collaborations; Collection; Communities; County; Data; Data Quality; Disease; Enrollment; Ensure; Epidemic; Funding; HIV; Highly Active Antiretroviral Therapy; Hour; Individual; International; Life; Link; Liquid substance; Medical center; Methods; Neurocognitive; Neurologic; Neuropsychology; Participant; Pathologic; Persons; Plasma; Positioning Attribute; Principal Investigator; Protocols documentation; Psychiatry; Qualifying; Recruitment Activity; Research; Research Personnel; Resources; Risk; Serum; Site; Specimen; Technical Expertise; Tissue Banking; Tissue Banks; Tissue Sample; Tissues; United States National Institutes of Health; Work; clinical research site; cohort; follow-up; human old age (65+); meetings; neurobehavioral; neuropathology; neuropsychological; public health relevance; quality assurance; response; success; AIDS neuropathy; Acquired Immunodeficiency Syndrome; Address; Age-Years; Aging; Aliquot; Anti-Retroviral Agents; Antiviral Agents; Autopsy; Brain; California; Cessation of life; Collaborations; Collection; Communities; County; Data; Data Quality; Disease; Enrollment; Ensure; Epidemic; Funding; HIV; Highly Active Antiretroviral Therapy; Hour; Individual; International; Life; Link; Liquid substance; Medical center; Methods; Neurocognitive; Neurologic; Neuropsychology; Participant; Pathologic; Persons; Plasma; Positioning Attribute; Principal Investigator; Protocols documentation; Psychiatry; Qualifying; Recruitment Activity; Research; Research Personnel; Resources; Risk; Serum; Site; Specimen; Technical Expertise; Tissue Banking; Tissue Banks; Tissue Sample; Tissues; United States National Institutes of Health; Work; clinical research site; cohort; follow-up; human old age (65+); meetings; neurobehavioral; neuropathology; neuropsychological; public health relevance; quality assurance; response; success

DESCRIPTION (provided by applicant): This is a renewal application for the California NeuroAIDS Tissue Network (CNTN) in response to the RFA- MH-13-070. The overarching objective of the CNTN remains the same today as it was when it was first established in 1998: to serve as a tissue bank resource comprised of CNS autopsy material from HIV- infected individuals who are well characterized neuropsychological and neuromedically in life. The CNTN has been very successful in meeting this primary objective. To date, we have enrolled a total of 821 participants, including 303 autopsies, 39,600 aliquots of plasma, 27,500 aliquots of CSF, 18,700 aliquots of serum, and 5,600 aliquots of PBMCs. For the current application, we are restructuring our cohort to best target and obtain autopsies from high priority cases that are aligned with the three thematic priorities identified in the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long term HAART, and c) HIV and aging. Specifically, we will target continuation of HIV+ participants who 1) are at greatest risk for death, 2) have been on ART for more than 10 years, and are greater than 50 years of age, which will provide valuable cases to the NNTC resource that are aligned with the NIH three thematic priorities. Specifically, we will recruit a cohort of 4 older (65+ years old) participants from a new collaboration with the Eisenhower Medical Center (EMC) in Palm Springs given that more than 10% H1V+ persons in Riverside County are 65,or older. CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. CNTN contributes to the NNTC by: 1) leading the NNTC Neuropsychology and Psychiatry subcommittee and overseeing quality assurance for these data, 2) guiding the methods for historical antiretroviral collection, 3) contributing to the refinement of the common NNTC assessment and neuropathology protocols, 4) providing review and fulfillment of NNTC-wide tissue and sample requests, and 5) serving on the NNTC Steering Committee.. The CNTN will work closely with the NNTC to ensure continued success of this exceptional national and international resource for research on neuroAIDS.

描述（由申请人提供）：这是针对RFA-MH-13-070的加利福尼亚神经辅助组织网络（CNTN）的续签应用。 CNTN的总体目标与1998年首次建立时保持不变：作为由CNS尸检材料组成的组织库资源，来自感染的HIV感染的个体，这些材料具有良好的神经心理学和生活中的神经疗法。 CNTN在满足这一主要目标方面非常成功。迄今为止，我们总共招募了821名参与者，其中包括303个尸检，39,600个等离子体，27,500名CSF等分试样，18,700个血清等分试样和5,600个PBMC。对于当前的应用，我们将同类群体重组为最佳目标，并从与RFA中确定的三个主题优先级一致的高优先级案例中获取尸检：a）来自中枢神经系统储层的HIV消除； b）在长期HAART和C）HIV和衰老的环境中与HIV相关的神经认知障碍（手）的机制。具体而言，我们将针对持续艾滋病毒+参与者的持续人物，他们1）处于最大死亡风险，2）已经使用了10年以上的艺术，并且大于50岁，这将为与NIH的NIH三个主题优先事项一致的NNTC资源提供有价值的案例。具体来说，我们将招募与棕榈泉的艾森豪威尔医疗中心（EMC）的新合作中的4个年龄较大（65岁以上）的参与者，因为河滨县的10％H1V+人有65％或更老。 CNTN是国家神经辅助组织联盟（NNTC）的活跃参与者，该联盟（NNTC）是四个由NIH资助的神经辅助组织组织的伙伴关系。 CNTN contributes to the NNTC by: 1) leading the NNTC Neuropsychology and Psychiatry subcommittee and overseeing quality assurance for these data, 2) guiding the methods for historical antiretroviral collection, 3) contributing to the refinement of the common NNTC assessment and neuropathology protocols, 4) providing review and fulfillment of NNTC-wide tissue and sample requests, and 5) serving on NNTC指导委员会。CNTN将与NNTC紧密合作，以确保这项非凡的国家和国际神经助理研究的成功。