CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) as a Resource

CNS HIV 抗逆转录病毒治疗效果研究 (CHARTER) 作为资源

• 批准号: 8163758
• 负责人: IGOR GRANT
• 金额: $ 29.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-16 至 2015-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8163758
• 关键词: CNS; HIV; Anti; Retroviral; Therapy

The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) was funded in September 2002 in response to RFA NIMH-00-AI-0005 with the aim of exploring the changing presentation of HIV neurological complications in the context of highly active antiretroviral therapy (HAART). CHARTER¿s major aims were to determine how central and peripheral nervous system complications of HIV were being affected by different histories and regimens of ART. Over the past 8 years, the six-site CHARTER project has accumulated invaluable clinical and research data on 1598 participants, with longitudinal data being collected on 674 of these participants. Data includes neuromedical characterization, neuropsychological functioning, psychiatric and drug abuse variables, treatment data, brain imaging, and viral and host genetics information. Each CHARTER visit generates approximately 4000 individual variables; currently the database contains over 5 million datapoints. A key component of CHARTER is to serve as a catalyst for additional studies/analyses by making this wealth of data available to investigators. To date, the CHARTER Coordinating Core and CHARTER Resource have facilitated research requests for 70 investigators across 18 institutions. In order to continue to make samples and data available to the neuroAIDS community, we propose to extend the ¿CHARTER as a Resource¿ facilities beyond the original CHARTER Option Period.

CNS HIV 抗逆转录病毒治疗效果研究 (CHARTER) 于 2002 年 9 月响应 RFA NIMH-00-AI-0005 资助，旨在探索高效抗逆转录病毒治疗 (HAART) 背景下 HIV 神经系统并发症的变化。宪章其主要目标是确定不同的 ART 历史和治疗方案对 HIV 中枢和周围神经系统并发症的影响 在过去 8 年中，六个地点的 CHARTER 项目积累了 1598 名参与者的宝贵临床和研究数据。对其中 674 名参与者收集的纵向数据包括神经医学特征、神经心理功能、精神和药物滥用变量、治疗数据、脑成像以及病毒和宿主遗传学信息。 4000 个单独变量；目前数据库包含超过 500 万个数据点。 CHARTER 的一个关键组成部分是通过向研究人员提供大量数据来促进更多研究/分析。迄今为止，CHARTER 协调核心和 CHARTER 资源已满足了 18 个机构的 70 名研究人员的研究请求。 为了继续向神经艾滋病界提供样本和数据，我们建议延长 ¿宪章作为资源¿超出原始包机选择期限的设施。