CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) as a Resource

CNS HIV 抗逆转录病毒治疗效果研究 (CHARTER) 作为资源

• 批准号: 8540327
• 负责人: IGOR GRANT
• 金额: $ 31.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-16 至 2015-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540327
• 关键词: AIDS neuropathy; Anti-Retroviral Agents; Back; Brain imaging; California; Clinical Research; Collaborations; Communities; Complement; Data; Data Set; Databases; Dictionary; Disease; Drug abuse; Feedback; Fostering; Funding; Genetic; HIV; Highly Active Antiretroviral Therapy; Image; Individual; Medical; Morbidity - disease rate; Neurocognitive; Neurologic; Neuropathy; Participant; Peripheral Nervous System Diseases; Procedures; Process; Protocols documentation; Research; Research Personnel; Research Project Grants; Resources; Sampling; System; Texas; Universities; Viral; Visit; Washington; antiretroviral therapy; base; catalyst; medical schools; mortality; neuropsychological; performance site; quality assurance

The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) was funded in 2002 with the aim of exploring the changing presentation of HIV neurological complications in the context of Highly Active Antiretroviral Therapy (HAART). The six performance sites of CHARTER (Johns Hopkins University, Mt. Sinai Medical School, University of California at San Diego, University of Texas Medical Branch at Galveston, University of Washington, Washington University at St. Louis), were able to standardize neuromedical, neuropsychological, psychiatric, neuropathy, and imaging protocols along with on-going quality assurance procedures. Two key conclusions to emerge from the CHARTER project are that HIV-Associated Neurocognitive Disorders (HAND) and peripheral neuropathy remain highly prevalent despite effective HIV treatments that have significantly reduced mortality and non-neurologic morbidities. The CHARTER project has accumulated invaluable clinical and research data with longitudinal data being collected on 674 participants. Data includes neuromedical characterization, neuropsychological functioning, psychiatric and drug abuse variables, treatment data, brain imaging, and viral and host genetics information. Each CHARTER visit generates approximately 4000 individual variables; currently the database contains over 5 million data points. A key component of the CHARTER project is to serve as a catalyst for additional studies and analyses by making this wealth of samples and data available to investigators. In order to continue to make samples and data sets available to the NeuroAIDS community, ¿CHARTER as a Resource¿ will be enhanced with the following; 1) CHARTER Imaging Utilities; 2) Document Collaboration Utilities to facilitate cross institutional collaboration (e.g., check-in/check-out systems, change tracking and automated document back-ups); 3) User Management Enhancements (e.g., access to warehoused data and community based utilities to foster cross institutional collaboration); and 4) Data Dictionary Enhancements. In addition, CHARTER as a Resource will solicit feedback from users to further enhance the Resource utilities. These enhancements will complement carefully constructed and established mechanisms for a) announcing the availability of the resource, b) soliciting requests, c) facilitating scientific review of all requests, and d) processing and distributing samples and data to scientific requestors.

CNS HIV 抗逆转录病毒治疗效果研究 (CHARTER) 于 2002 年资助，旨在探索高效抗逆转录病毒治疗 (HAART) 背景下 HIV 神经并发症的变化。 CHARTER 的六个实施地点（约翰·霍普金斯大学，山）。西奈医学院、加州大学圣地亚哥分校、德克萨斯大学加尔维斯顿分校医学分院、华盛顿大学、华盛顿大学圣路易斯分校）能够标准化神经医学， CHARTER 项目得出的两个关键结论是，尽管有效的 HIV 治疗已取得显着效果，但 HIV 相关神经认知障碍 (HAND) 和周围神经病变仍然非常普遍。降低死亡率和非神经系统发病率。 CHARTER 项目积累了宝贵的临床和研究数据，收集了 674 名参与者的纵向数据，数据包括神经医学特征、神经心理功能、精神病和药物滥用变量、治疗数据、脑成像以及每次 CHARTER 访问都会生成。大约 4000 个单独变量；目前该数据库包含超过 500 万个数据点，CHARTER 项目的一个关键组成部分是通过向研究人员提供大量样本和数据来促进进一步的研究和分析。 为了继续向 NeuroAIDS 社区提供样本和数据集，¿宪章作为资源¿将通过以下功能进行增强： 1) CHARTER 成像实用程序； 2) 促进跨机构协作的文档协作实用程序（例如，签入/签出系统、变更跟踪和自动文档备份）； （例如，访问仓库数据和基于社区的实用程序以促进跨机构协作）；以及 4) 数据字典增强 此外，CHARTER 作为资源将征求用户的反馈以进一步加强。增强资源效用。 这些增强功能将补充精心构建和建立的机制：a) 宣布资源的可用性，b) 征求请求，c) 促进对所有请求的科学审查，以及 d) 处理并向科学请求者分发样本和数据。