Socio-moral processing in female stimulant abuse and psychopathy

女性兴奋剂滥用和精神病的社会道德处理

基本信息

批准号：
9545201
负责人：
KENT A KIEHL
金额：
$ 29.95万
依托单位：
THE MIND RESEARCH NETWORK
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-01 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9545201
关键词：
Address Adult Affective Age of Onset Alcohol or Other Drugs use Amphetamines Amygdaloid structure Anatomy Anterior Area Award Basal Ganglia Behavior Behavioral Biological Biological Markers Biological Neural Networks Brain Brain region Categories Cocaine Communities Corpus Callosum Crime Data Data Set Decision Making Dimensions Disease Dorsal Drug abuse Etiology Female Forensic Medicine Functional Magnetic Resonance Imaging Funding Future Grant Image Analysis Impairment Imprisonment Intervention Lead Linguistics Magnetic Resonance Imaging Medial Mind Modality Modeling Morals Multimodal Imaging National Institute of Drug Abuse Nature Neuroanatomy Neurobiology Neurocognitive Outcome Parietal Participant Pattern Pharmaceutical Preparations Physiologic pulse Population Prefrontal Cortex Prisons Process Psychopath Public Health Publishing Relapse Research Sampling Severities Sex Characteristics Stimulus Structure Substance Use Disorder Substance abuse problem System Task Performances Temporal Lobe Testing Work amphetamine use anti social antisocial behavior base behavior test behavioral outcome brain circuitry cocaine use comorbidity cost density design frontal lobe functional MRI scan gender difference gray matter hemodynamics high risk improved interest male methamphetamine abuse neural circuit neuroimaging neuromechanism novel offender predictive modeling psychopathic personality public health relevance relapse prediction relating to nervous system response sex stimulant abuse substance abuse treatment trait treatment strategy white matter

项目摘要

There continues to be great interest and relevance to public health with regard to understanding the neurobiological systems that underlie the comorbidity of substance use disorders and other psychiatric conditions. In the previous funding period, we focused our efforts upon characterizing the neural circuitry underlying moral decision making in incarcerated adult males with varying levels of two frequently cooccurring conditions: stimulant abuse and psychopathy. Here we propose to extend this work to incarcerated adult females, to examine longitudinal outcomes, and to apply state-of-the-art image analyses to our predictive models. Studies published by our research team and others have demonstrated sex/gender differences in the degree and expression of psychopathic traits, patterns of stimulant abuse, and moral decision-making. However, the neural circuitry that underlies these sex differences is not well understood. We have also discovered substantial sex differences in regional gray matter density (n>500). Collectively, these sex differences could have significant implications for substance abuse treatment strategies and biomarkers of treatment prediction and outcome in males and females. We will implement the research strategy with a large incarcerated female population by deploying a unique mobile MRI scanner to the regional prison facility. Female participants will be stratified by their level of lifetime stimulant (cocaine, amphetamine) use severity and psychopathic traits (high, medium, low) and will undergo anatomical and functional MRI scanning while completing multi-modal (i.e., linguistic and picture) decision-making tasks. We will compare the results to those we obtained in the prior funding period with our male incarcerated sample (n>300). We will also examine functional network and dynamic network connectivity in females using a new multiband EPI pulse sequence, and collect longitudinal outcomes after release to the community and test behavioral/ neuropredictive models of relapse and future antisocial behavior. This work is expected to generate a large, robust dataset that characterizes the overlapping and unique aspects of neural circuitry underlying stimulant use and psychopathy in females and males. The proposed research is in line with the recent call by NIDA for projects aimed at examining male-female differences, and effects specific to females, to improve our understanding of the nature and etiology of drug abuse

关于理解神经生物学系统的合并症是药物使用障碍和其他精神病学的合并症状况。在上一个资金期间，我们将精力集中在表征神经电路上在不同水平的被监禁的成年男性中的基本道德决策经常合作条件：刺激性滥用和精神病。在这里，我们建议将这项工作扩展到被监禁成年女性，检查纵向结果，并将最新图像分析应用于我们的预测型号。我们的研究团队和其他人发表的研究表明了性别/性别差异精神病性状的程度和表达，刺激性滥用的模式和道德决策。但是，基于这些性别差异的神经回路尚不清楚。我们也有在区域灰质密度（n> 500）上发现了很大的性别差异。共同，这些性别差异可能对药物滥用治疗策略和生物标志物具有重大影响男性和女性的治疗预测和结果。我们将大量实施研究策略通过将独特的移动MRI扫描仪部署到区域监狱设施中，从而监禁女性。女性参与者将根据其终身兴奋剂（可卡因，苯丙胺）的水平进行分层和精神病性状（高，中，低），并且会进行解剖和功能性的MRI扫描完成多模式（即语言和图片）决策任务。我们将将结果与我们在以前的资金期间与男性被监禁的样本（n> 300）获得的。我们也会使用新的Multiband Epi脉冲检查女性的功能网络和动态网络连接序列，并在释放社区后收集纵向结果并测试行为/ 复发和未来反社会行为的神经审查模型。预计这项工作将产生一个大型的强大的数据集表征了刺激剂的神经回路的重叠和独特方面在女性和男性中使用和精神病。拟议的研究与NIDA最近呼吁旨在检查男女差异和特定女性的影响，以改善我们的了解药物滥用的性质和病因