Socio-moral processing in female stimulant abuse and psychopathy
女性兴奋剂滥用和精神病的社会道德处理
基本信息
- 批准号:9545201
- 负责人:
- 金额:$ 29.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-01 至 2018-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAffectiveAge of OnsetAlcohol or Other Drugs useAmphetaminesAmygdaloid structureAnatomyAnteriorAreaAwardBasal GangliaBehaviorBehavioralBiologicalBiological MarkersBiological Neural NetworksBrainBrain regionCategoriesCocaineCommunitiesCorpus CallosumCrimeDataData SetDecision MakingDimensionsDiseaseDorsalDrug abuseEtiologyFemaleForensic MedicineFunctional Magnetic Resonance ImagingFundingFutureGrantImage AnalysisImpairmentImprisonmentInterventionLeadLinguisticsMagnetic Resonance ImagingMedialMindModalityModelingMoralsMultimodal ImagingNational Institute of Drug AbuseNatureNeuroanatomyNeurobiologyNeurocognitiveOutcomeParietalParticipantPatternPharmaceutical PreparationsPhysiologic pulsePopulationPrefrontal CortexPrisonsProcessPsychopathPublic HealthPublishingRelapseResearchSamplingSeveritiesSex CharacteristicsStimulusStructureSubstance Use DisorderSubstance abuse problemSystemTask PerformancesTemporal LobeTestingWorkamphetamine useanti socialantisocial behaviorbasebehavior testbehavioral outcomebrain circuitrycocaine usecomorbiditycostdensitydesignfrontal lobefunctional MRI scangender differencegray matterhemodynamicshigh riskimprovedinterestmalemethamphetamine abuseneural circuitneuroimagingneuromechanismnoveloffenderpredictive modelingpsychopathic personalitypublic health relevancerelapse predictionrelating to nervous systemresponsesexstimulant abusesubstance abuse treatmenttraittreatment strategywhite matter
项目摘要
There continues to be great interest and relevance to public health with regard to understanding the
neurobiological systems that underlie the comorbidity of substance use disorders and other psychiatric
conditions. In the previous funding period, we focused our efforts upon characterizing the neural circuitry
underlying moral decision making in incarcerated adult males with varying levels of two frequently cooccurring
conditions: stimulant abuse and psychopathy. Here we propose to extend this work to incarcerated
adult females, to examine longitudinal outcomes, and to apply state-of-the-art image analyses to our predictive
models. Studies published by our research team and others have demonstrated sex/gender differences in the
degree and expression of psychopathic traits, patterns of stimulant abuse, and moral decision-making.
However, the neural circuitry that underlies these sex differences is not well understood. We have also
discovered substantial sex differences in regional gray matter density (n>500). Collectively, these sex
differences could have significant implications for substance abuse treatment strategies and biomarkers of
treatment prediction and outcome in males and females. We will implement the research strategy with a large
incarcerated female population by deploying a unique mobile MRI scanner to the regional prison facility.
Female participants will be stratified by their level of lifetime stimulant (cocaine, amphetamine) use severity
and psychopathic traits (high, medium, low) and will undergo anatomical and functional MRI scanning while
completing multi-modal (i.e., linguistic and picture) decision-making tasks. We will compare the results to
those we obtained in the prior funding period with our male incarcerated sample (n>300). We will also
examine functional network and dynamic network connectivity in females using a new multiband EPI pulse
sequence, and collect longitudinal outcomes after release to the community and test behavioral/
neuropredictive models of relapse and future antisocial behavior. This work is expected to generate a large,
robust dataset that characterizes the overlapping and unique aspects of neural circuitry underlying stimulant
use and psychopathy in females and males. The proposed research is in line with the recent call by NIDA for
projects aimed at examining male-female differences, and effects specific to females, to improve our
understanding of the nature and etiology of drug abuse
人们对于了解公共卫生仍然抱有极大的兴趣和相关性。
导致物质使用障碍和其他精神疾病合并症的神经生物学系统
状况。在之前的资助期间,我们的重点是表征神经回路
两种经常同时发生的不同程度的被监禁成年男性的基本道德决策
状况:兴奋剂滥用和精神病。在这里,我们建议将这项工作扩展到被监禁的人
成年女性,检查纵向结果,并将最先进的图像分析应用于我们的预测
模型。我们的研究团队和其他人发表的研究表明,性别/性别差异
精神病特征的程度和表达、兴奋剂滥用的模式以及道德决策。
然而,这些性别差异背后的神经回路尚不清楚。我们还有
发现区域灰质密度存在显着的性别差异(n>500)。总的来说,这些性别
差异可能对药物滥用治疗策略和药物滥用生物标志物产生重大影响
男性和女性的治疗预测和结果。我们将大力实施研究战略
通过在地区监狱设施中部署独特的移动核磁共振扫描仪来减少被监禁的女性人口。
女性参与者将根据她们终生使用兴奋剂(可卡因、安非他明)的严重程度进行分层
和精神病特征(高、中、低),并将接受解剖和功能 MRI 扫描,同时
完成多模态(即语言和图片)决策任务。我们将比较结果
我们在之前的资助期间通过男性被监禁样本 (n>300) 获得的数据。我们也会
使用新的多频带 EPI 脉冲检查女性的功能网络和动态网络连接
序列,并在发布到社区后收集纵向结果并测试行为/
复发和未来反社会行为的神经预测模型。这项工作预计将产生大量
强大的数据集,描述了兴奋剂背后的神经回路的重叠和独特方面
女性和男性的使用和精神病。拟议的研究符合 NIDA 最近的呼吁
旨在研究男女差异以及对女性的具体影响的项目,以改善我们的
了解药物滥用的性质和病因
项目成果
期刊论文数量(0)
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{{ truncateString('KENT A KIEHL', 18)}}的其他基金
Cloud based neuroimaging analysis for identifying traumatic braininjuries and related changes
基于云的神经影像分析,用于识别创伤性脑损伤和相关变化
- 批准号:
10827676 - 财政年份:2023
- 资助金额:
$ 29.95万 - 项目类别:
Neurocognitive Abnormalities in Stimulant Abuse among High-Risk Women
高危女性滥用兴奋剂导致的神经认知异常
- 批准号:
10522796 - 财政年份:2022
- 资助金额:
$ 29.95万 - 项目类别:
Neurocognitive Abnormalities in Stimulant Abuse among High-Risk Women
高危女性滥用兴奋剂导致的神经认知异常
- 批准号:
10669260 - 财政年份:2022
- 资助金额:
$ 29.95万 - 项目类别:
A longitudinal study of traumatic brain injury in a high-risk population
高危人群创伤性脑损伤的纵向研究
- 批准号:
10531141 - 财政年份:2022
- 资助金额:
$ 29.95万 - 项目类别:
A longitudinal study of traumatic brain injury in a high-risk population
高危人群创伤性脑损伤的纵向研究
- 批准号:
10676267 - 财政年份:2022
- 资助金额:
$ 29.95万 - 项目类别:
Mindfulness for Alcohol Abusing Offenders: Mechanisms and Outcomes
酗酒者的正念:机制和结果
- 批准号:
10668853 - 财政年份:2018
- 资助金额:
$ 29.95万 - 项目类别:
Mindfulness for Alcohol Abusing Offenders: Mechanisms and Outcomes
酗酒者的正念:机制和结果
- 批准号:
10398036 - 财政年份:2018
- 资助金额:
$ 29.95万 - 项目类别:
Mindfulness for Alcohol Abusing Offenders: Mechanisms and Outcomes
酗酒者的正念:机制和结果
- 批准号:
9915815 - 财政年份:2018
- 资助金额:
$ 29.95万 - 项目类别:
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