A longitudinal study of traumatic brain injury in a high-risk population

高危人群创伤性脑损伤的纵向研究

基本信息

批准号：
10676267
负责人：
KENT A KIEHL
金额：
$ 69万
依托单位：
LOVELACE BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-04 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676267
关键词：
Acceleration Address African American Age Algorithms Behavior Brain Brain Injuries Chronology Classification Clinical Clinical assessments Cognitive Communities Consent Data Data Set Databases Dementia Detection Diagnosis Diffusion Ethnic Origin Evaluation Female Follow-Up Studies Forensic Medicine Functional disorder Funding Future General Population Health Hispanic Image Impaired cognition Impairment Imprisonment Individual Injury Institution Laboratories Literature Longitudinal Studies Magnetic Resonance Imaging Measures Mental Depression Minority Groups Modeling National Institute of Neurological Disorders and Stroke Native Americans Neurocognitive Neurocognitive Deficit Neurodegenerative Disorders Neuropsychology Outcome Participant Pathologic Processes Pathology Phenotype Population Process Protocols documentation Public Health Race Recording of previous events Reproducibility Research Research Personnel Resources Risk Risk Factors Risk Taking Sampling Secure Severities Specific qualifier value Substance abuse problem Testing Time Traumatic Brain Injury Twin Multiple Birth Underserved Population United States National Institutes of Health Woman Work aged behavior prediction behavioral outcome brain based classification algorithm comorbidity data sharing ethnic diversity follow-up high risk population improved independent component analysis longitudinal dataset male men mild cognitive impairment mild traumatic brain injury multimodal neuroimaging neuroimaging neuroimaging marker offender pediatric trauma predictive modeling psychopathic personality sex social substance use tool

项目摘要

Project Summary/Abstract Traumatic brain injury (TBI) is a global concern that precipitates a diverse set of health consequences. TBI is a major concern in forensic populations -- an issue recently highlighted by calls for research by national public health institutions [1]. Indeed, upwards of 60% of inmates have a history of TBI, a rate seven times higher than the general population (8.5%) [2, 3]. TBI is a criminogenic risk factor [3, 4] and even mild TBI increases the rates of risk-taking behavior, substance use, and future offending [2, 4]. Over the last decade our team has been continuously funded by NIH to collect detailed clinical and neuroimaging protocols from over 4000 incarcerated men and women. We utilize a unique pair of twin mobile MRI units that are deployed directly on the secure grounds of forensic facilities, making it possible to conduct this research. Our dataset includes multimodal neuroimaging protocols, thorough clinical assessment, neuropsychological evaluations, and histories of TBI. All of our n>4000 offenders have consented to participate in longitudinal follow-up studies. For this project, we will commence a longitudinal study on n=300 individuals aged 35+, examining variables that will differentiate trajectories associated with cognitive impairments. We will also leverage advanced neuroimaging tools developed by our team to provide brain-based measures of cognitive decline and imaging-based classification tools for identifying brain injuries and comorbid conditions (i.e., substance abuse, psychopathy scores, depression, etc.). We will also examine how the brain injury profiles and comorbid conditions change over time. The availability of these unique resources to examine this highly underserved population makes this an exciting project with the potential to break new ground in our understanding of individual risk needs and divergent outcomes in TBI and neurodegenerative disease.

项目概要/摘要创伤性脑损伤 (TBI) 是一个全球性的问题，它会导致一系列不同的健康后果。 TBI 是一种法医群体主要关注的问题 -- -- 最近国家公众呼吁进行研究而强调的一个问题卫生机构[1]。事实上，超过 60% 的囚犯有 TBI 病史，这一比例是普通囚犯的七倍一般人群 (8.5%) [2, 3]。 TBI 是一种犯罪危险因素 [3, 4]，即使轻微的 TBI 也会增加犯罪率冒险行为、药物滥用和未来犯罪的风险 [2, 4]。在过去的十年里，我们的团队由 NIH 持续资助，从 4000 多名被监禁者中收集详细的临床和神经影像方案男女。我们利用一对独特的双移动 MRI 装置，直接部署在安全的法医设施的场地，使进行这项研究成为可能。我们的数据集包括多模式神经影像学方案、全面的临床评估、神经心理学评估和 TBI 病史。全部我们的 n> 4000 名罪犯中同意参加纵向跟踪研究。对于这个项目，我们将开始对 n=300 名 35 岁以上个体进行纵向研究，检查能够区分差异的变量与认知障碍相关的轨迹。我们还将利用先进的神经影像工具由我们的团队开发，提供基于大脑的认知衰退测量和基于成像的分类用于识别脑损伤和合并症的工具（即药物滥用、精神病评分、抑郁症等）。我们还将检查脑损伤情况和合并症如何随时间变化。可用这些独特的资源来检查这个服务严重不足的人群，这使得这是一个令人兴奋的事情该项目有可能在我们对个人风险需求和不同风险的理解方面开辟新天地 TBI 和神经退行性疾病的结果。