Externalizing outcomes in high risk youth

高危青少年的外化结果

基本信息

批准号：
10391465
负责人：
KENT A KIEHL
金额：
$ 65.13万
依托单位：
LOVELACE BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-05 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10391465
关键词：
Academia Adolescence Adolescent Adult Age of Onset Aggressive behavior Alcohols Anterior Area Attention Behavioral Biological Brain Brain imaging Collaborations Collection Complex Consent Crime Criminology Dangerousness Data Data Set Development Discipline Drug usage Evaluation Event Expenditure Family Firearms Follow-Up Studies Forensic Medicine Funding Future Gender Health Health Status Healthcare Image Impairment Imprisonment Individual Intervention Interview Investigation Knowledge Lateral Lead Life Life Cycle Stages MRI Scans Machine Learning Magnetic Resonance Imaging Maps Measures Medial Mental Health Methods Modeling Neurocognitive Neuropsychological Tests New Mexico Outcome Participant Pathologic Pattern Pharmaceutical Preparations Property Psychological Factors Psychosocial Factor Relapse Research Rest Risk Sampling Scanning Security Sociology Statistical Models Structure Substance abuse problem Sum Techniques Time United States United States National Institutes of Health Violence Work Youth anti social antisocial behavior behavioral outcome brain magnetic resonance imaging callous unemotional trait cognitive control cognitive neuroscience cohort convict correctional system cost developmental psychology efficacious treatment externalizing behavior follow-up high dimensionality high risk indexing maladaptive behavior multidimensional data multimodal data neural circuit neurodevelopment neuroimaging neuromechanism novel outcome prediction pediatric trauma predictive modeling prevent prospective protective factors psychologic psychosocial relating to nervous system repeat offender social social factors substance use trait impulsivity treatment strategy young adult

项目摘要

Project Summary/abstract Public attention has often been drawn to the relationship between violence and mental health issues, but violent behavior is a very complex phenomenon undergirded by myriad social, psychological, environmental, and biological influences. This project intends to investigate these influences among a large sample of previously incarcerated youth, following up with them and collecting valuable longitudinal data. Our team worked with these youth and their families collecting detailed psychological, behavioral, and neuroimaging measures as part of a previous NIH-funded investigation. The current project aims to re-assess these individuals (now young adults) to examine long-range positive (i.e., desistance from drug use/antisocial behavior) and negative (relapse to drugs, antisocial behavior) outcomes. We will collect new neuroimaging scans, which combined with prior MRI data, will be useful for quantifying trajectories of change that map to persistence and desistence from externalizing outcomes. Advanced machine-learning approaches will be utilized in conjunction with structural, functional, network, and dynamic network brain measures in addition to behavioral and psychological measures. Machine learning approaches are capable of identifying patterns in high-dimensional data and delineating the unique combinations of variables that are most predictive of specific outcome variables. Using these methods, we intend to define neural mechanisms that predict outcomes. We also aim to identify combinations of variables that confer greater risk for persistent antisocial behavior and violence. The translational value of this work will be to clarify informative patterns of data that may indicate preventable outcomes. Furthermore, neural measures indicative of specific vulnerability will be identified as specific targets for treatment and novel intervention strategies. By identifying specific vulnerabilities and the changes that accompany positive outcomes, we will be closer to understanding the best way to recognize and prevent costly violent behavior.

项目摘要/摘要公众的关注经常引起暴力与心理健康问题之间的关系，但暴力行为是一个非常复杂的现象，受到无数社会，心理，环境，和生物学影响。该项目旨在调查大量样本中的这些影响以前被监禁的年轻人跟进他们并收集了宝贵的纵向数据。我们的团队与这些年轻人及其家人一起收集详细的心理，行为和神经影像学作为先前NIH资助的调查的一部分措施。当前的项目旨在重新评估这些个体（现为年轻人）检查远距离阳性（即停止药物使用/反社会行为）和阴性（对药物的复发，反社会行为）的结果。我们将收集新的神经影像学扫描与先前的MRI数据相结合，将有助于量化该映射到的变化轨迹持久性和对外在结果的持久性。高级机器学习方法将是与结构，功能，网络和动态网络大脑测量一起使用行为和心理措施。机器学习方法能够识别高维数据并描述最可预测特定变量的独特组合结果变量。使用这些方法，我们打算定义预测结果的神经机制。我们还旨在确定变量的组合，这些变量赋予持续反社会行为的更大风险和暴力。这项工作的翻译价值将是阐明可能表明的数据的信息模式可预防的结果。此外，指示特定脆弱性的神经测量将被确定为治疗和新干预策略的特定目标。通过确定特定漏洞和伴随积极成果的变化，我们将更加了解认识和认可的最佳方法防止昂贵的暴力行为。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Quantitative Head Dynamics Associated with Interpersonal (Grandiose-Manipulative) Psychopathic Traits in Incarcerated Youth.

DOI：
10.1007/s10862-022-09988-2
发表时间：
2022-12
期刊：
JOURNAL OF PSYCHOPATHOLOGY AND BEHAVIORAL ASSESSMENT
影响因子：
1.6
作者：
Rodriguez, Samantha N;Gullapalli, Aparna R;Maurer, J Michael;Tirrell, Palmer S;Egala, Ugesh;Anderson, Nathaniel E;Harenski, Carla L;Kiehl, Kent A
通讯作者：
Kiehl, Kent A

Anomalous Moral Intuitions in Juvenile Offenders with Psychopathic Traits.

具有精神病特征的青少年罪犯的异常道德直觉。

DOI：
10.1016/j.jrp.2020.103962
发表时间：
2020
期刊：
Journal of research in personality
影响因子：
3.3
作者：
Fernandes,Sharlene;Aharoni,Eyal;Harenski,CarlaL;Caldwell,Michael;Kiehl,KentA
通讯作者：
Kiehl,KentA

Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders.

DOI：
10.1016/j.nicl.2023.103343
发表时间：
2023
期刊：
NEUROIMAGE-CLINICAL
影响因子：
4.2
作者：
Allen, Corey H.;Shold, Jenna;Maurer, J. Michael;Reynolds, Brooke L.;Anderson, Nathaniel E.;Harenski, Carla L.;Harenski, Keith A.;Calhoun, Vince D.;Kiehl, Kent A.
通讯作者：
Kiehl, Kent A.

Investigating error-related processing in incarcerated adolescents with self-report psychopathy measures.

DOI：
10.1016/j.biopsycho.2017.11.009
发表时间：
2018-03
期刊：
Biological psychology
影响因子：
2.6
作者：
Maurer JM;Steele VR;Fink BC;Vincent GM;Calhoun VD;Kiehl KA
通讯作者：
Kiehl KA

Psychometric properties of the Trauma Checklist 2.0 and its predictive utility of felony re-offending among high-risk juvenile offenders.

DOI：
10.1186/s13034-023-00656-1
发表时间：
2023-09-21
期刊：
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
影响因子：
5.6
作者：
Shold, Jenna N.;Maurer, J. Michael;Reynolds, Brooke L.;Gullapalli, Aparna R.;Allen, Corey H.;Edwards, Bethany G.;Anderson, Nathaniel E.;Harenski, Carla L.;Neumann, Craig S.;Kiehl, Kent A.
通讯作者：
Kiehl, Kent A.