Neurocognitive Abnormalities in Stimulant Abuse among High-Risk Women

高危女性滥用兴奋剂导致的神经认知异常

基本信息

批准号：
10669260
负责人：
KENT A KIEHL
金额：
$ 80.89万
依托单位：
LOVELACE BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10669260
关键词：
Address Amphetamines Amygdaloid structure Anatomy Anterior Antisocial Personality Disorder Area Award Basal Ganglia Biological Biological Markers Borderline Personality Disorder Brain Cocaine Cognition Cognitive Therapy Communities Consultations Corpus Callosum Data Data Set Decision Making Diffusion Dorsal Drug abuse Emotional Ensure Equipment Etiology Female Forensic Medicine Functional disorder Future Health High Risk Woman Image Impairment Imprisonment Individual Differences Intervention Lead Linguistics Magnetic Resonance Imaging Mental Health Mental disorders Methamphetamine Mindfulness Training Modeling Morals Multimodal Imaging National Institute of Drug Abuse Nature Neuroanatomy Neurobiology Neurocognitive Outcome Participant Pathologic Pathway Analysis Pattern Personality Personality Traits Pharmaceutical Preparations Physiologic pulse Population Prediction of Response to Therapy Prisons Process Psychopath Public Health Published Comment Publishing Relapse Request for Applications Research Resources Sampling Severities Sex Differences Social outcome Stimulant Substance Use Disorder Substance abuse problem System Task Performances Temporal Lobe Testing Time Treatment outcome United States National Institutes of Health Woman Work anti social antisocial behavior behavior test cognitive process comorbidity cost density design frontal lobe functional MRI scan gender difference gray matter high risk high risk population improved independent component analysis interest men multimodality neural circuit neural network neuromechanism novel offender predictive modeling programs psychopathic personality relapse prediction response sex stimulant abuse stimulant use trait treatment strategy white matter

项目摘要

Project Abstract There continues to be great interest and public/health/relevance with regard to understanding the neurobiological systems that underlie the comorbidity of substance use disorders and other psychiatric conditions. In a previous R01 award, we focused our efforts upon characterizing the neural circuitry underlying moral decision making in incarcerated men with varying levels of two frequently co-occurring conditions: stimulant abuse and psychopathy. Here we propose to extend this work to incarcerated women, examine longitudinal outcomes, and apply stateof-the-art network analyses for predictive models. Studies published by our research team have demonstrated sex differences in the degree and expression of psychopathic traits, patterns of stimulant abuse, and moral decision-making. However, the neural circuitry that underlies these sex differences is not well understood. We have also identified substantial sex differences in regional gray matter volume and density in our extant samples. Collectively, sex differences in pathophysiology could have significant implications for treatment strategies and differential biomarkers of treatment prediction and outcome in men and women. We will implement the research strategy with a large incarcerated population by deploying a unique mobile MRI scanner to the regional women’s prison. Participants will be stratified by their level of lifetime stimulant (cocaine, amphetamine) use severity and psychopathic traits (high, medium, low) and will undergo anatomical and functional MRI scanning while completing multi-modal (i.e., linguistic and picture) decision-making tasks. We will also examine functional network and dynamic network connectivity in women using a new multiband EPI pulse sequence, and collect longitudinal outcomes after release to the community and test behavioral and neuropredictive models of relapse and future antisocial behavior. This work is expected to generate a large, robust dataset that characterizes the overlapping and unique aspects of neural circuitry underlying stimulant use and psychopathy in females. The proposed research is in line with recent priorities emphasized by NIDA for projects aimed at examining gender differences, and effects specific to females, to improve our understanding of the nature and etiology of drug abuse.

项目摘要关于理解神经生物学具有物质使用障碍和其他精神疾病的合并症的系统。在上一个 R01奖，我们将精力集中在表征道德决策基础的神经回路上被监禁的男性具有不同水平的两个经常出现的疾病：刺激性滥用和精神病。在这里，我们建议将这项工作扩展到被监禁的妇女，检查纵向结果，并应用网络分析的状态进行预测模型。我们的研究团队发表的研究表明精神病特征的程度和表达的性别差异，刺激性滥用的模式和道德决策。但是，基于这些性别差异的神经回路尚不清楚。我们还确定了我们广泛样本中区域灰质体积和密度的实质性差异。总的来说，病理生理学的性别差异可能对治疗策略和男女治疗预测和结果的差异生物标志物。我们将实施研究通过向区域妇女部署独特的移动MRI扫描仪，与大量监禁人口的战略监狱。参与者将根据其终身兴奋剂（可卡因，苯丙胺）的水平进行分层精神病性状（高，中，低），并且会进行解剖和功能性MRI扫描完成多模式（即语言和图片）决策任务。我们还将检查功能使用新的多播EPI脉冲序列的女性网络和动态网络连通性，并收集释放社区后的纵向结果，并测试退休的行为和神经审查模型和未来的反社会行为。预计这项工作将产生一个大型，坚固的数据集，以表征在女性中使用刺激性使用和精神病的神经回路的重叠和独特的方面。拟议的研究与NIDA对旨在检查性别的项目强调的最新优先事项一致差异和特定于女性的影响，以提高我们对药物性质和病因的理解虐待。