Age-related differences in neurobiological systems supporting emotion

支持情绪的神经生物系统与年龄相关的差异

基本信息

批准号：
10606216
负责人：
Mallory Jean Feldman
金额：
$ 3.92万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10606216
关键词：
Address Adult Affective Affective Symptoms Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Attention Award Brain Brain scan Cardiovascular Diseases Cardiovascular system Central Nervous System Cognitive aging Cohort Studies Communities Data Data Analytics Decision Making Dementia Development Disease Elderly Emotional Emotional disorder Emotions Equation Functional Magnetic Resonance Imaging Grant Health Health Promotion Healthcare Informal Social Control Interoception Journals Knowledge Learning Life Link Longevity Measurement Measures Memory Mental Health Mentorship Methodology Methods Modeling Motivation Neurobiology Older Population Participant Patient Self-Report Peer Review Peripheral Peripheral Nervous System Personal Satisfaction Persons Physiological Physiology Policies Policy Maker Population Postdoctoral Fellow Prevention Process Productivity Regulation Reporting Research Sampling Scientific Advances and Accomplishments Scientist Structure Supervision Support System System Techniques Testing Training United States National Institutes of Health age difference age related aging population bodily sensation cognitive process comparative efficacy emotion regulation emotional experience experience falls geriatric depression graph learning graph theory investigator training lectures multimodality neurobiological mechanism novel physical conditioning positive emotional state skill acquisition social relationships support network symposium ultra high resolution young adult

Address Adult Affective Affective Symptoms Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Attention Award Brain Brain scan Cardiovascular Diseases Cardiovascular system Central Nervous System Cognitive aging Cohort Studies Communities Data Data Analytics Decision Making Dementia Development Disease Elderly Emotional Emotional disorder Emotions Equation Functional Magnetic Resonance Imaging Grant Health Health Promotion Healthcare Informal Social Control Interoception Journals Knowledge Learning Life Link Longevity Measurement Measures Memory Mental Health Mentorship Methodology Methods Modeling Motivation Neurobiology Older Population Participant Patient Self-Report Peer Review Peripheral Peripheral Nervous System Personal Satisfaction Persons Physiological Physiology Policies Policy Maker Population Postdoctoral Fellow Prevention Process Productivity Regulation Reporting Research Sampling Scientific Advances and Accomplishments Scientist Structure Supervision Support System System Techniques Testing Training United States National Institutes of Health age difference age related aging population bodily sensation cognitive process comparative efficacy emotion regulation emotional experience experience falls geriatric depression graph learning graph theory investigator training lectures multimodality neurobiological mechanism novel physical conditioning positive emotional state skill acquisition social relationships support network symposium ultra high resolution young adult

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项目摘要

PROJECT SUMMARY Our global population is aging faster than ever, promising challenges for healthcare and community wellness. Affective processes are known to support health and wellbeing across the lifespan. Consequently, a better understanding of these processes has profound implications for the prevention and treatment of health disorders (e.g., geriatric depression, cardiovascular disease, dementia) and for policies supporting adults into later life. Older adults reliably report greater positive emotions, less aroused negative emotions, and greater emotion regulation efficacy compared to younger adults. These changes have primarily been attributed to age-related shifts in cognitive processes like attention, memory, motivation, control, and self-regulation. However, older adults also demonstrate less robust autonomic responding during emotion, lesser sensitivity to bodily sensations (interoception), and maladaptive gut-based decision-making. Collectively, these findings point to a novel hypothesis: the Physiological Hypothesis of Emotional Aging (PHEA). PHEA hypothesizes that age-related shifts in functional activation and connectivity within the allostatic interoceptive brain network (AIN) produce changes in emotional experience via concurrent changes in interoception and peripheral reactivity. The proposed project evaluates this hypothesis across three scientific aims leveraging data from sponsor Lindquist’s on-going cohort study of adults (n = 120, 18-80 years old). Participants in this study complete an in-lab session, one week of experience sampling, and a functional brain scan yielding measures of physiological reactivity, interoceptive ability, and emotional reactivity both in-lab and in-daily life. The proposed project is accompanied by 6 specific training objectives that will help the applicant to build new expertise in the neurobiology of affective aging, cutting- edge experimental methodologies (e.g., in-scanner acquisition of autonomic physiology, ultrahigh resolution functional brain scanning), and data analytic techniques (e.g., graph theory). The scientific aims and training objectives outlined in this proposal will better our understanding of basic mechanisms underlying healthy and disordered emotional aging; will help scientists, practitioners and policymakers address the health needs of our aging population; and will support the applicant’s transition into a productive and independent research scientist.

项目摘要我们的全球人口比以往任何时候都更快，对医疗保健和社区健康的挑战承诺。情感过程已知可以支持整个生命周期的健康和福祉。因此，更好对这些过程的理解对预防和治疗健康疾病具有深远的影响（例如，老年抑郁症，心血管疾病，痴呆症）以及支持成年人晚期生活的政策。老年人可靠地报告了更大的积极情绪，较少引起的负面情绪和更大的情绪与年轻人相比，调节效率。这些变化主要归因于年龄相关认知过程中的转变，例如注意力，记忆，动机，控制和自我调节。但是，年龄较大成年人在情绪期间还表现出较少的自主反应，对身体感觉的敏感性较小（Interoception）和基于适应不良的肠道决策。总的来说，这些发现指出了一部小说假设：情绪衰老的生理假设（PHEA）。 PHEA假设与年龄相关的变化在功能激活和连通性中，同性观察性脑网络（AIN）产生变化在情感体验中，通过拦截和外围反应性的同时变化。拟议的项目在三个科学目的中评估了这一假设成人研究（n = 120，18-80岁）。这项研究的参与者完成了一次单击课程，一周经验采样，功能性脑扫描产生身体反应性，互感的度量能力和情感反应性，包括在线和每日生活。拟议的项目由6个特定的培训目标将帮助申请人建立新的专业知识，以了解情感衰老的神经生物学边缘实验方法（例如，自主生理学内扫描仪，超高分辨率功能性脑扫描）和数据分析技术（例如，图理论）。科学目的和培训该提案中概述的目标将更好地理解我们对基本机制的理解健康且无序的情绪衰老；将帮助科学家，从业者和政策制定者解决人口老龄化的健康需求；并将支持申请人向富有成效的过渡和独立研究科学家。