Wadsworth Center's Human Health and Exposure Analysis Resource (WC-HHEAR)

沃兹沃斯中心的人类健康和暴露分析​​资源 (WC-HHEAR)

• 批准号: 10434774
• 负责人: Kurunthachalam Kannan
• 金额: $ 148.83万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10434774
• 关键词: Adipose tissue; Amniotic Fluid; Biological; Biological Assay; Biological Markers; Biological Monitoring; Blood; Chemicals; Client; Collaborations; Collection; Communication; Consult; Consultations; Coupled; Data; Data Reporting; Development; Dryness; Ensure; Environmental Exposure; Environmental Health; Environmental Pollutants; Follicular Fluid; Funding; Goals; Guidelines; Hair; Health; Heart; Human; Human Milk; Individual; Infrastructure; International; Knowledge; Laboratories; Laboratory Study; Leadership; Life; Liquid substance; Measurement; Measures; Meconium; Methodology; Methods; Mission; Nail plate; Paper; Periodicals; Phase; Placenta; Procedures; Production; Provider; Public Health; Publications; Publishing; Recommendation; Research Design; Research Institute; Research Personnel; Research Project Grants; Resource Development; Resources; Sampling; Schedule; Seminal Plasma; Shipping; Specimen; Spottings; Techniques; Testing; Tissues; Tooth structure; Trace Elements; Umbilical cord structure; United States National Institutes of Health; Work; bone; cost; data exchange; data harmonization; data quality; detection limit; environmental stressor; epidemiology study; experience; high standard; improved; instrumentation; interest; laboratory experience; novel; novel strategies; operation; pollutant; population survey; programs; prospective; success; symposium

PROJECT SUMMARY / ABSTRACT – OVERALL The proposed Wadsworth Center Human Health Exposure Analysis Resource (WC-HHEAR): Targeted Exposure Analysis Laboratory leverages access to a well-established targeted biomonitoring laboratory based at Wadsworth, which is recognized internationally as a world class public health laboratory and research institute. Wadsworth has developed significant capability and capacity for the targeted analyses required to help HHEAR become a success and has added experience from having been one of the six CHEAR laboratory hubs. The proposed WC-HHEAR resource is led by two MPIs with over 65 years of combined experience analyzing biospecimens for organic and inorganic targets, and who have collaborated together and with other researchers for two decades to advance our understanding of environmental exposures and human health; their collective contributions amount to over 700 published papers in the field of exposure measurements. The Administrative Core will provide an effective infrastructure and the support to ensure that WC-HHEAR is well-integrated into the Wadsworth’s Division of Environmental Health Sciences. Staff from the Administrative Core will work to confirm the day-to-day lab hub operations are smooth, and that excellent communications are maintained within the hub, and between the hub, the other HHEAR components, and with HHEAR clients. The proposed WC-HHEAR Targeted Analysis Resource (TAR), which is at the heart of this proposal, offers extensive capabilities that extend over 30 chemical classes, and hundreds of individual targets, and in many different biological tissues and fluids. The benefit to HHEAR clients includes multiple pre-and-post analytical consultations with experienced laboratory staff and subject matter experts that have reputations for high-quality analytical work. The TAR will also leverage the experience and capability that Wadsworth brings as an international provider of proficiency testing and as a producer of well-characterized biological reference materials that will help ensure the harmonization of data reported by laboratories world-wide for trace elements and trace organics in biological matrices. The WC-HHEAR Development Core will work to advance existing methods to improve efficiency, and achieve lower limits of detection, while working with increasingly smaller sample masses/volumes. The Development Core will also work to extend our capabilities in non-traditional matrices, increasing the number of targets measured and in many more matrices. Additionally, WC-HHEAR will adapt to the challenges ahead, whether driven by discoveries in the untargeted resource, or from HHEAR clients requesting increased throughput for our established assays.

项目摘要 /摘要 - 总体 拟议的Wadsworth中心人类健康暴露分析资源（WC-HHEAR）：针对性 暴露分析实验室利用访问良好的目标生物监测实验室的访问权限 在沃兹沃思（Wadsworth），在国际上被认为是世界一流的公共卫生实验室和研究所。 沃兹沃思（Wadsworth 成为成功，并增加了六个Chear实验室中心之一的经验。这 拟议的WC-HHEAR资源由两个MPI领导，拥有超过65年的合并经验分析 有机和无机靶标的生物测量，并与其他研究人员合作 二十年来，我们对环境暴露和人类健康的理解；他们的集体 在暴露测量领域中，贡献等于700多个发表的论文。行政 核心将提供有效的基础架构和支持，以确保WC-HHEAR已充分融合到 沃兹沃思环境卫生科学系。行政核心的工作人员将有效确认 日常实验室集线器操作很顺利，并且在枢纽内保持出色的通信， 在集线器，其他HHEAR组件以及HHEAR客户之间。拟议的WC-HEAR 有针对性的分析资源（TAR）是该提案的核心，提供了广泛的功能来扩展 超过30种化学类别，数百个单个靶标，以及许多不同的生物组织和流体。 对HHEAR客户的好处包括与经验丰富的实验室的多次前和分析咨询 对高质量分析工作进行评论的员工和主题专家。焦油也将利用 沃兹沃思（Wadsworth）作为国际水平测试提供商的经验和能力 特征良好的生物参考材料的生产商，这些材料将有助于确保数据的协调 全球实验室报告的痕量元素和痕量有机物在生物材料中。 WC-HEAR 开发核心将努力提高现有方法以提高效率，并达到下限 检测，同时使用越来越小的样品质量/体积。发展核心也将 为扩展非传统物质的能力的工作，增加了测量的目标数量和 更多的矩阵。此外，WC-HHEAR将适应未来的挑战，无论是被发现驱动的 在未靶向的资源中，或者来自Hear客户，要求我们既定的测定法的吞吐量增加。