MEASUREMENT OF ENVRIRONMENTAL CHEMICALS IN THE EAGeR TRIAL

EGeER 试验中环境化学物质的测量

• 批准号: 9569856
• 负责人: Kurunthachalam Kannan
• 金额: $ 67.73万
• 依托单位: NYSDOH/HEALTH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-22 至 2019-03-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9569856
• 关键词: Accounting; Adult; Area; Aromatic Polycyclic Hydrocarbons; Aspirin; Benzophenones; Biological Assay; Biological Markers; Chemicals; Contractor; Data; Data Sources; Detection; Dose; Endocrine Disruptors; Endocrine disruption; Evaluation; Exposure to; Fertility; Folic Acid; General Population; Gold; Impairment; Individual; Laboratories; Live Birth; Measurement; Measures; Methods; Occupational Exposure; Outcome; Ovulation; Oxidative Stress; Parabens; Phenols; Pregnancy; Pregnancy Outcome; Pregnancy loss; Property; Prospective Studies; Randomized Controlled Trials; Recording of previous events; Reproduction; Reproductive Health; Research; Risk; Role; Sampling; Serum; Site; Spottings; Testing; Time; Urine; Visit; Woman; Work; adverse pregnancy outcome; cost; environmental chemical; environmental chemical exposure; falls; follow-up; novel; phthalates; pregnant; prospective; repository; reproductive; sample collection; trial design

The Effects of Aspirin in Gestation and Reproduction (EAGeR) Trial is a multi-site, prospective doubleblind randomized controlled trial designed to assess the effects of low-dose aspirin in combination with folic acid treatment on pregnancy and gestation among 1228 women with a history of 1-2 pregnancy losses. A large biospecimen repository is available for analysis and offers a good platform for testing multiple hypotheses. This statement of work is for the measurement of stored biospecimens in the EAGeR Trial. The proposed assays will provide a rich data source on biomarker levels that can answer novel research questions in conjunction with the extensive data already collected in the EAGeR Trial. A growing body of evidence suggests that exposure to many common environmental chemicals, particularly those with endocrine-disrupting properties, may be associated with impaired fecundability and increased risk of adverse pregnancy outcomes. However, much of the findings to date have been equivocal. There is a need to further investigate the potential role of environmental chemical exposures in leading to adverse reproductive and gestational outcomes, particularly among prospective studies with gold standard ascertainment of reproductive and pregnancy outcomes. Due to much prior research being conducted among individuals with occupational exposure, there is also a need for additional research among healthy adults with similar exposure levels to the general population, to ascertain whether background exposure to key environmental chemicals may pose reproductive health risks. Finally, although phenols, such as BPA, and phthalates are known endocrine disruptors, few studies have evaluated their association with reproductive outcomes. There is also a great need for research on emerging endocrine disruptors, including parabens and benzophenones, and reproductive outcomes.

阿司匹林在妊娠和繁殖（急切）试验中的影响是一项多站点的，前瞻性的双盲随机对照试验，旨在评估低剂量阿司匹林与叶酸治疗对叶酸治疗对妊娠和妊娠1-2妊娠历史孕妇妊娠的妊娠和妊娠的影响。可用于分析的大型生物测量存储库，并为测试多个假设提供了一个良好的平台。这项工作声明是用于在急切的试验中测量存储的生物测量。拟议的测定法将提供有关生物标志物水平的丰富数据源，该数据可以与急切试验中已经收集的广泛数据一起回答新的研究问题。越来越多的证据表明，接触许多常见的环境化学物质，尤其是那些具有内分泌特性的环境化学物质，可能与繁殖力受损和不良妊娠结局的风险增加有关。但是，迄今为止的许多发现都是模棱两可的。有必要进一步研究环境化学暴露在导致不良生殖和妊娠结局中的潜在作用，尤其是在具有生殖和妊娠结局的黄金标准确定的前瞻性研究中。由于在职业曝光的个体中进行了许多事先研究，因此在与普通人群相似的健康成年人中还需要进行额外的研究，以确定背景暴露于关键环境化学物质是否可能构成生殖健康风险。最后，尽管BPA和邻苯二甲酸酯等酚是已知的内分泌干扰物，但很少有研究评估它们与生殖结果的关联。还需要研究新兴的内分泌破坏者，包括对羟基苯甲酸酯和苯甲酮，以及生殖结果。