Wadsworth Center's Human Health and Exposure Analysis Resource (WC-HHEAR)

沃兹沃斯中心的人类健康和暴露分析​​资源 (WC-HHEAR)

• 批准号: 10222672
• 负责人: Kurunthachalam Kannan
• 金额: $ 227.15万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10222672
• 关键词: Adipose tissue; Amniotic Fluid; Biological; Biological Assay; Biological Markers; Biological Monitoring; Blood; Chemicals; Client; Collaborations; Collection; Communication; Consult; Consultations; Coupled; Data; Data Reporting; Development; Ensure; Environmental Exposure; Environmental Health; Environmental Pollutants; Environmental Pollution; Follicular Fluid; Funding; Goals; Guidelines; Hair; Health; Heart; Human; Human Milk; Individual; Infrastructure; International; Knowledge; Laboratories; Laboratory Research; Leadership; Life; Liquid substance; Measurement; Measures; Meconium; Methodology; Methods; Mission; Nail plate; Paper; Periodicity; Phase; Placenta; Procedures; Production; Provider; Public Health; Publications; Publishing; Recommendation; Research Design; Research Institute; Research Personnel; Research Project Grants; Resource Development; Resources; Sampling; Schedule; Seminal Plasma; Shipping; Specimen; Spottings; Techniques; Testing; Tissues; Tooth structure; Trace Elements; Umbilical cord structure; United States National Institutes of Health; Work; base; bone; cost; data exchange; data harmonization; data quality; detection limit; environmental stressor; epidemiology study; experience; high standard; improved; instrumentation; interest; laboratory experience; novel; novel strategies; operation; pollutant; population survey; programs; prospective; success; symposium

PROJECT SUMMARY / ABSTRACT – OVERALL The proposed Wadsworth Center Human Health Exposure Analysis Resource (WC-HHEAR): Targeted Exposure Analysis Laboratory leverages access to a well-established targeted biomonitoring laboratory based at Wadsworth, which is recognized internationally as a world class public health laboratory and research institute. Wadsworth has developed significant capability and capacity for the targeted analyses required to help HHEAR become a success and has added experience from having been one of the six CHEAR laboratory hubs. The proposed WC-HHEAR resource is led by two MPIs with over 65 years of combined experience analyzing biospecimens for organic and inorganic targets, and who have collaborated together and with other researchers for two decades to advance our understanding of environmental exposures and human health; their collective contributions amount to over 700 published papers in the field of exposure measurements. The Administrative Core will provide an effective infrastructure and the support to ensure that WC-HHEAR is well-integrated into the Wadsworth’s Division of Environmental Health Sciences. Staff from the Administrative Core will work to confirm the day-to-day lab hub operations are smooth, and that excellent communications are maintained within the hub, and between the hub, the other HHEAR components, and with HHEAR clients. The proposed WC-HHEAR Targeted Analysis Resource (TAR), which is at the heart of this proposal, offers extensive capabilities that extend over 30 chemical classes, and hundreds of individual targets, and in many different biological tissues and fluids. The benefit to HHEAR clients includes multiple pre-and-post analytical consultations with experienced laboratory staff and subject matter experts that have reputations for high-quality analytical work. The TAR will also leverage the experience and capability that Wadsworth brings as an international provider of proficiency testing and as a producer of well-characterized biological reference materials that will help ensure the harmonization of data reported by laboratories world-wide for trace elements and trace organics in biological matrices. The WC-HHEAR Development Core will work to advance existing methods to improve efficiency, and achieve lower limits of detection, while working with increasingly smaller sample masses/volumes. The Development Core will also work to extend our capabilities in non-traditional matrices, increasing the number of targets measured and in many more matrices. Additionally, WC-HHEAR will adapt to the challenges ahead, whether driven by discoveries in the untargeted resource, or from HHEAR clients requesting increased throughput for our established assays.

项目概要/摘要——总体 拟议的沃兹沃斯中心人类健康暴露分析资源 (WC-HHEAR)：有针对性 暴露分析实验室利用基于完善的目标生物监测实验室的访问权限 沃兹沃思是国际公认的世界级公共卫生实验室和研究机构。 Wadsworth 已开发出帮助 HHEAR 所需的目标分析的重要能力和能力 取得了成功，并作为六个 CEAR 实验室中心之一积累了丰富的经验。 提议的 WC-HHEAR 资源由两个拥有超过 65 年综合分析经验的 MPI 领导 有机和无机目标的生物样本，以及与其他研究人员合作的人 二十年来增进我们对环境暴露和人类健康的理解； 在暴露测量领域已发表论文 700 多篇。 Core 将提供有效的基础设施和支持，以确保 WC-HHEAR 很好地集成到 沃兹沃斯环境健康科学部门的行政核心人员将努力确认。 实验室中心的日常运营顺利，并且中心内保持良好的通信， 以及集线器、其他 HHEAR 组件以及与 HHEAR 客户端之间的连接。 目标分析资源 (TAR) 是该提案的核心，它提供了广泛的功能，可扩展 超过 30 种化学类别、数百个单独目标以及许多不同的生物组织和体液。 HHEAR 客户的好处包括与经验丰富的实验室进行多次分析前和分析后咨询 因高质量分析工作而享有盛誉的工作人员和主题专家也将利用 TAR。 Wadsworth 作为国际能力验证提供商和 良好表征的生物参考材料的生产商，这将有助于确保数据的统一 世界各地实验室针对生物基质中的微量元素和微量有机物进行了报告 WC-HHEAR。 开发核心将致力于推进现有方法以提高效率，并实现更低的限制 检测，同时处理越来越小的样品质量/体积。开发核心也将。 努力扩展我们在非传统矩阵方面的能力，增加测量的目标数量和 此外，WC-HHEAR 将适应未来的挑战，无论是由发现驱动的。 在非目标资源中，或者来自 HHEAR 客户要求提高我们已建立的测定的通量。