ENVIRONMENTAL CHEMICAL ANALYSIS OF HUMAN SPECIMENS FOR DIPHR - PROJECT TRACKING AND CONSULTATION

DIPHR 人体样本的环境化学分析 - 项目跟踪和咨询

基本信息

批准号：
9305284
负责人：
Kurunthachalam Kannan
金额：
$ 5.03万
依托单位：
NYSDOH/HEALTH RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-20 至 2017-06-19
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9305284
关键词：
Acetaminophen Acids Adult Aliquot Aromatic Polycyclic Hydrocarbons Benzophenones Biological Markers Blood Caffeine Caring Chemicals Child Child health care Chlordan Chlorophenols Consultations Contracts Cotinine Coumestrol Creatinine Data Collection Development Dichlorodiphenyl Dichloroethylene Diet Elements Environment Environmental Exposure Epidemiologic Studies Fluorine Follicular Fluid Genistein Hair Health behavior Human Hydrocarbons Infant Intervention Studies Laboratories Lanthanoid Series Elements Life Life Style Melatonin Metals Mirex Mono-S Nail plate National Institute of Child Health and Human Development Newborn Infant Nicotine Observational Study Omentum Organ Oxidative Stress Parabens Perchlorates Peritoneal Fluid Pesticides Pharmaceutical Preparations Phenols Phytoestrogens Placenta Plasma Polybrominated Biphenyls Polychlorinated Biphenyls Population Pregnant Women Protocols documentation Pyrenes Reproduction Research Research Project Grants Saliva Sampling Scheme Scientist Seminal fluid Sleep Specific Gravity Specimen Spottings Stress Subgroup Tissues Tobacco smoke Trace Elements Triclosan Ultraviolet Rays Urine Vitamins Whole Blood adolescent health bisphenol A daidzein design dichlorodiphenyltrichloroethane enterodiol enterolactone environmental chemical equol inorganic phosphate interest metabolomics non-genetic o,p&apos -DDT organochlorine pesticide oxychlordane phthalates polybrominated diphenyl ether population health repository reproductive hormone

项目摘要

The Division of Intramural Population Health Research (DIPHR) conducts research on a variety of topics pertaining to human reproduction and development, child and adolescent health and behaviors, and care of pregnant women among other topics. Both observational and interventional research is designed and implemented by Division scientists, and most research includes multi-faceted collection of data and biospecimens. This includes subgroups of the population such as infants and children, who are likely to have even lower concentrations than adults. All biospecimens are collected using approved protocols and are de-identified prior banking in NICHD-supported repositories. A wide range of biospecimen types are collected including whole blood, plasma, serum, peritoneal fluid, urine, saliva, tissue (e.g. omental fat), organs (e.g., placenta), hair, nails, follicular and seminal fluids, semen, and newborn blood spots. The Division conducts research focusing on the relationship between environmental exposures and human reproduction and development, as broadly defined. The Division defines environment as non-genetic, including environmental chemicals, diet, and lifestyle. Within the scope of environmental chemicals, both persistent (e.g., metals and trace elements, organochlorine pesticides, perfluorochemicals, polybrominated biphenyls, polychlorinated biphenyls, polybrominated diphenyl ethers) and non-persistent (e.g. parabens, phenols, phthalates) chemicals are of interest. Of note is the Division’s research focusing on emerging classes of chemicals as well as biomarkers of lifestyle exposures and diet. Moreover, ophisticated aliquoting schemes are typically required for much of the Division’s research to enable additional biomedical laboratory analyses to compliment the environmental analyses. For example, a plasma sample may be used for the quantification of persistent chemicals and for metabolomic analyses, while a urine sample may be analyzed for both short-lived chemicals, such as phthalates, and for reproductive hormones.

壁内人口健康研究（DIPHR）的划分进行了有关与人类繁殖和发展有关的各种主题，儿童和青少年健康和行为以及对孕妇的照顾以及其他主题的研究。观察性研究和介入研究都是由部门科学家设计和实施的，大多数研究包括多面数据和生物测量的收集。这包括婴儿和儿童等人口的亚组，这些人群的浓度可能比成人较低。所有生物测量都是使用批准的协议收集的，并在NICHD支持的存储库中被取消确定的银行业务。收集了广泛的生物植物类型，包括全血，血浆，血清，腹膜液，尿液，唾液，组织（例如肿瘤脂肪），器官（例如胎盘），头发，指甲，卵泡和卵泡液和精液，精液，精液和新生儿血液点。划分进行研究，重点是环境暴露与人类繁殖与发展之间的关系，如广义上的定义。该部门将环境定义为非遗传学，包括环境化学物质，饮食和生活方式。在环境化学物质的范围内，均具有持久性（例如金属和微量元素，有机氯农药，全氟化学物质，多溴化的二苯基，多溴化的二苯基醚）和非持久性（例如，羟基苯甲酸酯，苯酚，腓骨）具有兴趣。值得注意的是该部门的研究重点是新兴的化学物质以及生活方式暴露和饮食的生物标志物。此外，该部门的大部分研究通常需要光学等分方案，以使其他生物医学实验室分析能够补充环境分析。例如，血浆样品可用于定量持续化学物质和代谢组学分析，而可以分析两种短寿命化学物质（例如邻苯二甲酸盐）和复制激素的尿液样品。