REPOSITORY SERVICES FOR THE MATERNAL AND PEDIATRIC INFECTIOUS DISEASES BRANCH SPECIMENS

孕产妇和儿童传染病分支标本保藏服务

• 批准号: 10934306
• 负责人: CHRISTOPHER PARSONS
• 金额: $ 3.08万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-09 至 2020-09-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10934306
• 关键词: Adipose tissue; Adolescent; Amniotic Fluid; Biological Specimen Banks; Blood; Candida; Cell Extracts; Cells; Cervical; Child; Childhood; Clinical Trials; Cohort Studies; Communicable Diseases; Contracts; Cryopreserved Cell; DNA; Data; Dental Plaque; Dose; Drug Kinetics; Dryness; Endometrial; Equipment and supply inventories; Erythrocytes; Foundations; Funding; Future; Goals; HIV; HIV Infections; HIV therapy; HIV-exposed uninfected infant; HIV/AIDS; Human; Infant; Infection; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Liquid substance; Meconium; Monitor; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; Participant; Peripheral Blood Mononuclear Cell; Pharyngeal structure; Placenta; Plasma; Population; Pregnant Women; Prevention; Protocols documentation; Public Health Schools; Research; Safety; Saliva; Science; Serum; Services; Site; Specimen; Spottings; Swab; Symptoms; System; Technology; Temperature; Tissues; Umbilical Cord Blood; United States; Urine; Vagina; Vertical Disease Transmission; Youth; antiretroviral therapy; blood lipid; clinical center; combat; cytokine; data management; frontier; neutrophil; operation; pediatric human immunodeficiency virus; perinatal HIV; programs; repository; support network; young woman

The NICHD Human BioSpecimen Repository shall provide the services of storage, monitoring, and distribution for the Maternal and Pediatric Infectious Disease Branch (MPIDB). Required repository services therefore include planning discussions with repository staff to adequately prepare for specimens, receipt of specimens from multiple clinical centers, purchase of freezers to store the specimens, storage of the specimens at the required temperatures; an on-line, searchable inventory system of all specimens, and shipment of biospecimens to analytical labs. The Maternal and Pediatric Infectious Disease Branch (MPIDB) promotes research to investigate the impact of HIV and its treatment on specific populations (pregnant women, infants, children, and adolescents) with the goal of increasing our understanding so we can better combat this infection. There are two main networks supported by the MPIDB that actively collect specimens to be housed in the NICHD repository. These are PHACS (Pediatric HIV AIDS Cohort Study) and IMPMCT (International Maternal Pediatric and Adolescent AIDS Clinical Trials). The Pediatric HIV AIDS Cohort Study (PHACS) is a multicenter United States-based program that follows both perinatally HIV-infected youth and HIV-exposed/uninfected infants, children, and youth. The IMPAACT Network is focused on evaluating potential therapies for HIV infection and its related symptoms in infants, children, adolescents, and pregnant women, including clinical trials of HIV/AIDS interventions for and prevention of mother-to-child transmission. The research agenda includes studies on the pharmacokinetics, safety, optimal dosing, and long-term complications of new antiretroviral (ARV) therapies for HIV/AIDS in pediatric and adolescent populations and in pregnant women. NICHD-funded sites (via Westat contract) utilize the NICHD repository; NIAID-funded sites utilize a separate NIAID-supported repository. NICHD­ supported sites also perform other trials independently or within other networks. PHACS collects/stores the following types of specimens from the over 3000 participants currently being followed on 3 main protocols and additional substudies:

NICHD人类生物循环存储库应提供存储，监视和 孕产妇和小儿传染病分支（MPIDB）的分布。因此，所需的存储库服务包括与存储库工作人员进行的计划讨论，以充分准备标本，从多个临床中心收到标本，购买冰柜以存放标本，存储标本在所需的温度下；所有标本的在线，可搜索的库存系统，以及将生物测量运送到分析实验室的运输。 孕产妇和小儿传染病分支（MPIDB）促进了研究，以研究HIV及其对特定人群（孕妇，婴儿，儿童和青少年）的治疗的影响，目的是提高我们的理解，以便我们更好地应对这种感染。 MPIDB支持的两个主要网络积极收集要容纳在NICHD存储库中的标本。这些是PHAC（小儿艾滋病毒 艾滋病队列研究）和IMPMCT（国际母亲小儿和青少年艾滋病 临床试验）。 小儿艾滋病毒艾滋病队列研究（PHACS）是一项基于美国的多中心计划，遵循周围感染了HIV的青年和受HIV暴露/未感染的婴儿，儿童和青年。 该网络的重点是评估艾滋病毒感染的潜在疗法及其在婴儿，儿童，青少年和孕妇中的相关症状，包括艾滋病毒/艾滋病干预措施的临床试验，以预防和预防母亲传播。该研究议程包括有关新抗逆转录病毒（ARV）疗法的药代动力学，安全性，最佳剂量以及针对儿科和青少年种群以及孕妇的HIV/艾滋病的长期并发症。 NICHD资助的站点（通过西合同）利用NICHD存储库； NIAID资助的站点利用单独的NIAID支持的存储库。 NICHD支持的站点还独立或在其他网络中执行其他试验。 PHACS收集/存储以下类型的标本类型，目前正在遵循3个主要协议和其他物质的3000多名参与者：