REPOSITORY SERVICES FOR THE MATERNAL AND PEDIATRIC INFECTIOUS DISEASES BRANCH SPECIMENS

孕产妇和儿童传染病分支标本保藏服务

• 批准号: 9536544
• 负责人: CHRISTOPHER PARSONS
• 金额: $ 43.13万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-09 至 2017-09-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9536544
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adipose tissue; Adolescent; Amniotic Fluid; Blood; Candida; Cell Extracts; Cells; Cervical; Child; Childhood; Clinical; Clinical Trials; Cohort Studies; Communicable Diseases; Contracts; Cryopreserved Cell; DNA; Data; Dental Plaque; Dose; Drug Kinetics; Endometrial; Equipment and supply inventories; Erythrocytes; Foundations; Freezing; Funding; Future; Goals; HIV; HIV Infections; HIV therapy; HIV-exposed uninfected infant; Human; IMPAACT; Infant; Infection; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Liquid substance; Meconium; Monitor; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; Participant; Perinatal; Pharyngeal structure; Placenta; Plasma; Population; Pregnant Women; Prevention; Protocols documentation; Public Health Schools; Research; Safety; Saliva; Science; Serum; Services; Ships; Site; Specimen; Spottings; Swab; Symptoms; System; Technology; Temperature; Tissues; Umbilical Cord Blood; United States; Urine; Vagina; Vertical Disease Transmission; Youth; antiretroviral therapy; base; blood lipid; combat; cytokine; data management; frontier; neutrophil; operation; pediatric human immunodeficiency virus; programs; repository; support network; young woman

The NICHD Human BioSpecimen Repository shall provide the services of storage, monitoring, and distribution for the Maternal and Pediatric Infectious Disease Branch (MPIDB). Required repository services therefore include planning discussions with repository staff to adequately prepare for specimens, receipt of specimens from multiple clinical centers, purchase of freezers to store the specimens, storage of the specimens at the required temperatures; an on-line, searchable inventory system of all specimens, and shipment of biospecimens to analytical labs. The Maternal and Pediatric Infectious Disease Branch (MPIDB) promotes research to investigate the impact of HIV and its treatment on specific populations (pregnant women, infants, children, and adolescents) with the goal of increasing our understanding so we can better combat this infection. There are two main networks supported by the MPIDB that actively collect specimens to be housed in the NICHD repository. These are PHACS (Pediatric HIV AIDS Cohort Study) and IMPMCT (International Maternal Pediatric and Adolescent AIDS Clinical Trials). The Pediatric HIV AIDS Cohort Study (PHACS) is a multicenter United States-based program that follows both perinatally HIV-infected youth and HIV-exposed/uninfected infants, children, and youth. The IMPAACT Network is focused on evaluating potential therapies for HIV infection and its related symptoms in infants, children, adolescents, and pregnant women, including clinical trials of HIV/AIDS interventions for and prevention of mother-to-child transmission. The research agenda includes studies on the pharmacokinetics, safety, optimal dosing, and long-term complications of new antiretroviral (ARV) therapies for HIV/AIDS in pediatric and adolescent populations and in pregnant women. NICHD-funded sites (via Westat contract) utilize the NICHD repository; NIAID-funded sites utilize a separate NIAID-supported repository. NICHD­ supported sites also perform other trials independently or within other networks. PHACS collects/stores the following types of specimens from the over 3000 participants currently being followed on 3 main protocols and additional substudies:

NICHD人类生物样本库应当提供存储、监测和服务。 因此，母婴传染病处 (MPIDB) 所需的样本库服务包括与样本库工作人员进行规划讨论，以充分准备样本、从多个临床中心接收样本、购买冰柜来储存样本、将样本储存在所需的温度；所有样本的在线可搜索库存系统，以及将生物样本运送到实验室分析。 母婴传染病处 (MPIDB) 促进研究艾滋病毒及其治疗对特定人群（孕妇、婴儿、儿童和青少年）的影响，目的是增进我们的了解，以便更好地对抗这种感染。 MPIDB 支持两个主要网络，它们主动收集标本并存放在 NICHD 存储库中。 艾滋病队列研究）和 IMPMCT（国际孕产妇儿科和青少年艾滋病） 临床试验）。 儿科艾滋病毒艾滋病队列研究 (PHACS) 是一项以美国为基础的多中心项目，跟踪围产期感染艾滋病毒的青少年以及暴露/未感染艾滋病毒的婴儿、儿童和青少年。 IMPAACT 网络专注于评估婴儿、儿童、青少年和孕妇的艾滋病毒感染及其相关症状的潜在疗法，包括针对艾滋病毒/艾滋病干预措施和预防母婴传播的临床试验。针对儿科和青少年人群以及孕妇的艾滋病毒/艾滋病新型抗逆转录病毒 (ARV) 疗法的药代动力学、安全性、最佳剂量和长期并发症的研究利用了 NICHD 资助的站点（通过 Westat 合同）。 NICHD 存储库；NIAID 资助的站点使用独立的 NIAID 支持的存储库，也可以独立或在其他网络内进行其他试验。 PHACS 从目前正在跟踪 3 个主要方案和其他子研究的 3000 多名参与者中收集/存储以下类型的标本：