Omega-3 Fatty Acids, Cardiovascular Risk and Behavior

Omega-3 脂肪酸、心血管风险和行为

基本信息

批准号：
8216010
负责人：
MATTHEW F MULDOON
金额：
$ 33.61万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-02-01 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8216010
关键词：
Adult Affect Affective Age-Years Aggressive behavior American American Heart Association Amygdaloid structure Anger Arachidonate 5-Lipoxygenase Atherosclerosis Attention Deficit Disorder Behavior Behavior assessment Behavioral Biological Availability Biological Markers Brain imaging Cardiovascular Diseases Carotid Arteries Cause of Death Cell physiology Chronic Coenzyme A Communities Consumption Detection Diet Eating Epidemiology Event Fatty Acids Fish Oils Fishes Forensic Medicine Genes Genetic Polymorphism Genetic Variation Goals Heart Diseases Heart Rate Homeostasis Hostility Impulsivity Individual Differences Inflammation Intake Interleukin-6 Intervention Interview Investigation Laboratories Ligase Link Lipoxygenase Literature Major Depressive Disorder Measures Medial Mental Depression Mental Health Methods Micronutrients Moods Neurophysiology - biologic function Observational Study Omega-3 Fatty Acids Participant Patients Personal Satisfaction Persons Phenotype Phospholipids Placebo Control Primary Prevention Production Program Research Project Grants Proteins Psychometrics Relative (related person)Reporting Research Rest Rewards Risk Behaviors Risk Factors Role Sampling Serum Stimulus Structure Supplementation Testing Thick Ultrasonography Variant Vascular Diseases Ventral Striatum base biobehavior cardiovascular disorder risk cardiovascular risk factor cyclooxygenase 2 cytokine depressive symptoms disability emotion regulation fatty acid metabolism heart disease risk heart rate variability heart rhythm inflammatory marker instrument mortality neuronal cell body pre-clinical promoter psychologic psychosocial relating to nervous system research study standard measure volunteer

项目摘要

Long-chain omega-3 fatty acids are available primarily via consumption of fish and are known to serve many important roles in cell function and body homeostasis. Furthermore, these micronutrients reduce cardiovascular disease (CVD) events when supplemented in the diets of patients with pre-existing heart disease. Given that Americans currently consume an average of only 120 mg of long-chain omega-3 fatty acids each day,the American Heart Association now recommends now recommends that all adults eat fish, particularly fatty fish, as least twice a week. As yet there is little direct evidence to support such an advisory since it is not clear either whether or how increasing fish consumption in the diet of the general pubic will reduce the risk of heart disease. In separate research, a relative deficiency in the omega-3 fatty acids has been associated with major depression, attention-deficit disorder and aggressive behavior in forensic samples. Once again, studies in healthy adults are lacking. Project 3 of this Program Project Grant application proposes to conduct two investigations, an observational study of 530 generally-healthy community volunteers 30-55 year of age,and,in a subset reporting low consumption of omega-3 fatty acids, a placebo-controlled supplementation experiment of 4 months duration. In both studies, markers of cardiovascular risk will be measured, as will psychological and behavioral characterises that have previously been linked to heart disease and omega-3 fatty acid availability. In addition, the observational study will include carotid ultrasound as a measure of pre-clinical atherosclerosis and functional brain imaging of regions regulating affect/threat detection and impulsivity/goal-directed behaviors. The research will test the hypotheses that high or raised EPA and DMA intake: 1) reduces CVD risk, 2) reduces depressive symptoms and antagonistic disposition, 3) reduces impulsivity and aggression, and 4) is related to activation of neural structures involved in affect and goal- directed behaviors. Finally, the effects of variation in genes regulating fatty acid metabolism will be studied.

长链 omega-3 脂肪酸主要通过食用鱼类获得，已知可用于多种用途在细胞功能和身体稳态中发挥重要作用。此外，这些微量营养素还可以减少在患有心脏病的患者的饮食中添加补充剂会导致心血管疾病 (CVD) 事件疾病。鉴于美国人目前平均仅消耗 120 毫克长链 omega-3 脂肪每天酸，美国心脏协会现在建议所有成年人吃鱼，尤其是富含脂肪的鱼，每周至少两次。到目前为止，还没有什么直接证据支持这样的建议因为尚不清楚公众是否愿意或如何增加饮食中的鱼类消费降低患心脏病的风险。在单独的研究中，omega-3 脂肪酸的相对缺乏导致法医样本显示，它与重度抑郁症、注意力缺陷障碍和攻击行为有关。再次缺乏对健康成年人的研究。本计划项目3 项目资助申请建议进行两项调查，一项针对 530 名总体健康的社区志愿者的观察性研究 30-55 岁，并且，在一个报告 omega-3 脂肪酸消耗量低的子集中，安慰剂对照为期4个月的补充实验。在这两项研究中，心血管风险的标志物将是测量，以及先前与心脏病相关的心理和行为特征和 omega-3 脂肪酸的可用性。此外，观察性研究将包括颈动脉超声作为临床前动脉粥样硬化的测量和调节情感/威胁检测区域的功能性脑成像和冲动/目标导向的行为。该研究将检验高或提高 EPA 和 DMA 摄入量：1) 降低 CVD 风险，2) 减少抑郁症状和对抗性倾向，3) 减少冲动和攻击性，4）与涉及情感和目标的神经结构的激活有关定向行为。最后，将研究调节脂肪酸代谢的基因变异的影响。