Distress, Fish Oil, Inflammation, and Heart Disease

痛苦、鱼油、炎症和心脏病

• 批准号: 6958824
• 负责人: MATTHEW F MULDOON
• 金额: $ 11.14万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6958824
• 关键词: acute phase protein; behavioral /social science research tag; cardiovascular disorder risk; chronic disease /disorder; clinical research; coronary disorder; depression; dietary lipid; human data; human tissue; inflammation; interleukin 6; lipid structure; malnutrition; marine animal oil; mathematical model; nutrition related tag; omega 3 fatty acid; phospholipids; psychological stressor; statistics /biometry; acute phase protein; behavioral /social science research tag; cardiovascular disorder risk; chronic disease /disorder; clinical research; coronary disorder; depression; dietary lipid; human data; human tissue; inflammation; interleukin 6; lipid structure; malnutrition; marine animal oil; mathematical model; nutrition related tag; omega 3 fatty acid; phospholipids; psychological stressor; statistics /biometry

DESCRIPTION (provided by applicant): Psychological distress, including depression, and coronary heart disease (CHD) remain major causes of morbidity and mortality. Furthermore, psychological distress, itself, appears to increase the risk of CHD. However, the biological mechanism(s) through which psychological distress and CHD are related remain poorly understood. Recent evidence implicates deficient dietary consumption of fish oil (supplying omega-3 fatty acids) in both psychological distress and CHD. The proposed research would utilize structural equation modeling to test a hypothesized model positing that psychological distress and CHD share a causal factor - dietary omega-3 fatty acid deficiency - in which chronic, systemic inflammation serves as the mediating variable. Subjects will be 300 healthy community volunteers; already participating in a funded investigation (HL40962). The requested grant would: a) support additional assays of phospholipid fatty acid composition, interleukin-6 and C-reactive protein made possible through a new collaboration between the principal investigator and Dr. Jeffrey Yao, and b) support biostatistical analysis using structural equation modeling. Results of the study could redirect current conceptualizations of the relationship between psychological factors and CHD risk, and lead to randomized clinical trials testing new interventions.

描述（由申请人提供）：心理困扰，包括抑郁症和冠状动脉疾病（CHD）仍然是发病率和死亡率的主要原因。此外，心理困扰本身似乎增加了CHD的风险。但是，与心理困扰和冠心病相关的生物学机制仍然对理解不足。最近的证据表明，在心理困扰和冠心病中，鱼油（供应omega-3脂肪酸）的饮食不足。拟议的研究将利用结构方程建模来测试一个假设的模型，该模型认为心理困扰和CHD具有因果关系因素 - 饮食中的omega -3脂肪酸缺乏 - 其中慢性，全身性炎症可作为中介变量。受试者将是300名健康的社区志愿者；已经参加了资助的调查（HL40962）。请求的赠款将：a）支持磷脂脂肪酸组成，白介素6和C反应蛋白的其他测定，这是通过首席研究员与Jeffrey Yao博士之间的新合作而实现的，而B）支持使用结构方程建模的生物统计学分析。该研究的结果可能会重定向心理因素与冠心病风险之间关系的当前概念化，并导致随机临床试验测试新的干预措施。