EFFECTS OF OMEGA-3 FATTY ACIDS ON COGNITIVE PERFORMANCE

OMEGA-3 脂肪酸对认知能力的影响

基本信息

批准号：
7648335
负责人：
MATTHEW F MULDOON
金额：
$ 15.15万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7648335
关键词：
Adult Affect Age-Years American Apolipoprotein E Attention Award Blood Brain Cardiovascular Diseases Cardiovascular system Cell membrane Clinical Cognition Cognitive Communities Consumption Data Data Collection Dementia Development Diet Dietary intake Docosahexaenoic Acids Eating Education Elderly Fatty Acids Fish Oils Fishes Gene Expression General Population Genotype Health Heart Diseases Human Impulsivity Incidence Individual Inflammation Intake Learning Link Malnutrition Measures Mediating Memory Mental Health Neuropsychological Tests Nutrient Omega-3 Fatty Acids Patients Performance Placebo Control Process Psyche structure Randomized Regulation Research Research Support Risk Short-Term Memory Signal Transduction Source Speed Supplementation Symptoms Testing Tissues Work cardiovascular disorder risk cognitive function executive function heart disease risk improved information processing middle age neuropsychological placebo controlled study programs public health relevance research study secondary outcome treatment duration volunteer

项目摘要

DESCRIPTION (provided by applicant): The long-chain omega-3 fatty acids are essential nutrients found primarily in fish. Most Americans eat little fish and, therefore, may be at risk for health sequelae. Clinical trail evidence generally indicates beneficial effects of fish oil supplementation: a) on cardiovascular disease incidence in patients with heart disease and, b) in terms of symptom amelioration in psychiatric patient groups. However, the effects of supplementation in the general population are unknown. The applicant and his colleagues have recently received support to conduct a randomized and placebo-controlled clinical experiment in healthy, adult community volunteers to test the effects of fish oil supplementation on markers for cardiovascular disease risk, negative affect and impulsivity. New observational evidence now also links low dietary intake or tissue levels of omega-3 fatty acids to poor cognitive functioning or dementia. The objective of the proposed research is to examine in the context of the described study the putative cognitive effects of supplementation in healthy adults who habitually consume little or no fish. This new, secondary outcome would entail administration of a battery of neuropsychological tests assessing working and general memory, psychomotor speed, attention and executive function at baseline and after at the end of the treatment period. Any demonstrable improvements in cognitive performance with supplementation would indicate both that dietary deficiency negatively affects cognition and that such performance decrements are reversible in a practical manner through increased omega-3 fatty acid consumption. PUBLIC HEALTH RELEVANCE: The long-chain omega-3 fatty acids are essential nutrients that are highly concentrated in the brain yet Americans typically consume very little of these nutrients in their diets. Since some evidence links low intake with poor cognitive function, the planned research would test whether taking a supplement of omega-3 fatty acids improves mental speed, information processing, and memory.

描述（由申请人提供）：长链omega-3脂肪酸是主要在鱼类中发现的必需营养素。大多数美国人吃了很少的鱼，因此可能有后遗症的风险。临床跟踪证据通常表明补充鱼油的有益作用：a）心脏病患者的心血管疾病发病率，b）在精神病患者组的症状改善方面。但是，补充对普通人群的影响尚不清楚。申请人及其同事最近在健康的成人社区志愿者中进行了随机和安慰剂对照的临床实验的支持，以测试补充鱼油对心血管疾病风险，负面影响和冲动性的标志物的影响。现在，新的观察证据也将低饮食摄入量或omega-3脂肪酸的组织水平与认知功能或痴呆症差。拟议的研究的目的是在描述的研究的背景下检查补充习惯几乎没有或根本没有鱼的健康成年人的假定认知作用。这个新的次要结果将需要进行一系列神经心理学测试，以评估工作和一般记忆，心理运动速度，注意力和执行功能在基线时以及治疗期结束后。补充认知表现的任何明显改善都将表明饮食不足会对认知产生负面影响，并且通过增加omega-3脂肪酸消耗，这种绩效降低以实际方式可逆。公共卫生相关性：长链omega-3脂肪酸是必不可少的营养素，它们高度集中在大脑中，但美国人通常在饮食中消耗的这些营养素很少。由于一些证据将低摄入量与认知功能较差联系起来，因此计划的研究将测试服用omega-3脂肪酸是否可以改善精神速度，信息处理和记忆。