Omega-3 Fatty Acids, Cardiovascular Risk and Behavior

Omega-3 脂肪酸、心血管风险和行为

• 批准号: 7318147
• 负责人: MATTHEW F MULDOON
• 金额: $ 30.39万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-07 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7318147
• 关键词: Acids; Adult; Affect; Affective; Age-Years; Aggressive behavior; American; American Heart Association; Amygdaloid structure; Anger; Applications Grants; Arachidonate 5-Lipoxygenase; Atherosclerosis; Attention Deficit Disorder; Behavior; Behavior assessment; Behavioral; Biological Availability; Biological Markers; Brain imaging; Cardiovascular Diseases; Carotid Arteries; Cause of Death; Cell physiology; Chronic; Coenzyme A; Communities; Consumption; Detection; Diet; Docosahexaenoic Acids; Eating; Event; Fatty Acids; Fish Oils; Fishes; Forensic Medicine; Genes; Genetic Polymorphism; Genetic Variation; Goals; Heart Diseases; Heart Rate; Homeostasis; Hostility; Impulsivity; Individual Differences; Inflammation; Inflammatory; Intake; Interleukin-6; Intervention; Interview; Investigation; Laboratories; Ligase; Link; Lipoxygenase; Literature; Major Depressive Disorder; Measures; Medial; Mental Depression; Mental Health; Methods; Micronutrients; Moods; Neurophysiology - biologic function; Observational Study; Omega-3 Fatty Acids; Participant; Patients; Personal Satisfaction; Persons; Phenotype; Phospholipids; Placebo Control; Primary Prevention; Production; Program Research Project Grants; Proteins; Psychometrics; Relative (related person); Reporting; Research; Research Personnel; Rest; Rewards; Risk Behaviors; Risk Factors; Role; Sampling; Serum; Standards of Weights and Measures; Stimulus; Structure; Supplementation; Testing; Thick; Ultrasonography; United States Environmental Protection Agency; Variant; Vascular Diseases; Ventral Striatum; Week; base; cardiovascular disorder risk; cardiovascular risk factor; cysteine rich protein; cytokine; day; depressive symptoms; disability; emotion regulation; fatty acid metabolism; heart disease risk; heart rhythm; instrument; mortality; pre-clinical; programs; promoter; psychologic; psychosocial; relating to nervous system; research study; volunteer

Long-chain omega-3 fatty acids are available primarily via consumption of fish and are known to serve many important roles in cell function and body homeostasis. Furthermore, these micronutrients reduce cardiovascular disease (CVD) events when supplemented in the diets of patients with pre-existing heart disease. Given that Americans currently consume an average of only 120 mg of long-chain omega-3 fatty acids each day,the American Heart Association now recommends now recommends that all adults eat fish, particularly fatty fish, as least twice a week. As yet there is little direct evidence to support such an advisory since it is not clear either whether or how increasing fish consumption in the diet of the general pubic will reduce the risk of heart disease. In separate research, a relative deficiency in the omega-3 fatty acids has been associated with major depression, attention-deficit disorder and aggressive behavior in forensic samples. Once again, studies in healthy adults are lacking. Project 3 of this Program Project Grant application proposes to conduct two investigations, an observational study of 530 generally-healthy community volunteers 30-55 year of age,and,in a subset reporting low consumption of omega-3 fatty acids, a placebo-controlled supplementation experiment of 4 months duration. In both studies, markers of cardiovascular risk will be measured, as will psychological and behavioral characterises that have previously been linked to heart disease and omega-3 fatty acid availability. In addition, the observational study will include carotid ultrasound as a measure of pre-clinical atherosclerosis and functional brain imaging of regions regulating affect/threat detection and impulsivity/goal-directed behaviors. The research will test the hypotheses that high or raised EPA and DMA intake: 1) reduces CVD risk, 2) reduces depressive symptoms and antagonistic disposition, 3) reduces impulsivity and aggression, and 4) is related to activation of neural structures involved in affect and goal- directed behaviors. Finally, the effects of variation in genes regulating fatty acid metabolism will be studied. Relevance: CVD remains a leading cause of death and disability, and the search for new preventative interventions remains a prioty. Increasing fish and fish oil consmption appears to reduce mortality in patients with prexisiting heart disease and may have salutory effects on psychological health and well-being. The proposed research will more clearly establish whether fish oil supplementation reduces heart disease risk factors and is associated with other benefial effects on mood, antagonsitic disposition and impulsivity.

长链omega-3脂肪酸主要是通过食用鱼类的，已知可以为许多 在细胞功能和身体稳态中的重要作用。此外，这些微量营养素还原 心血管疾病（CVD）事件在饮食中补充饮食 疾病。鉴于美国人目前平均消耗120毫克的长链omega-3脂肪 酸每天，美国心脏协会现在建议现在建议所有成年人吃鱼， 特别是脂肪鱼，至少每周两次。到目前为止，几乎没有直接证据支持这种咨询 由于尚不清楚一般耻骨饮食中的鱼类消耗是否会增加 降低心脏病的风险。在单独的研究中，omega-3脂肪酸的相对缺乏具有 与大抑郁症，注意力缺陷障碍和法医样本中的侵略性行为有关。 再次缺乏对健康成年人的研究。该计划项目3的项目赠款申请提出了 为了进行两项调查，一项对530个健康社区志愿者的观察性研究30-55 年龄，并且在报告欧米茄3脂肪酸消耗的子集中，安慰剂对照 持续4个月的补充实验。在这两项研究中，心血管风险的标记将是 经过测量，心理和行为的特征也将与心脏病联系在一起 和omega-3脂肪酸的可用性。此外，观察性研究将包括颈动脉超声 临床前动脉粥样硬化和调节影响/威胁检测的区域功能性脑成像的度量 和冲动/目标指导的行为。该研究将检验高EPA或提高EPA的假设以及 DMA摄入量：1）降低CVD风险，2）减少抑郁症状和拮抗性，3）减少 冲动性和侵略性，以及4）与激活情感和目标有关的神经结构的激活 定向行为。最后，将研究调节脂肪酸代谢的基因变异的影响。 相关性：CVD仍然是死亡和残疾的主要原因，并寻求新的预防措施 干预措施仍然是一种挑战。鱼油和鱼油的增加似乎降低了患者的死亡率 具有预见的心脏病，可能会对心理健康和福祉产生有益的影响。这 拟议的研究将更清楚地确定补充鱼油是否会降低心脏病风险 因素，与其他对情绪，反语言性格和冲动性的受益影响有关。