Distress, Fish Oil, Inflammation, and Heart Disease

痛苦、鱼油、炎症和心脏病

• 批准号: 7140283
• 负责人: MATTHEW F MULDOON
• 金额: $ 10.88万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7140283
• 关键词: acute phase protein; behavioral /social science research tag; cardiovascular disorder risk; chronic disease /disorder; clinical research; coronary disorder; depression; dietary lipid; human data; human tissue; inflammation; interleukin 6; lipid structure; malnutrition; marine animal oil; mathematical model; nutrition related tag; omega 3 fatty acid; phospholipids; psychological stressor; statistics /biometry

DESCRIPTION (provided by applicant): Psychological distress, including depression, and coronary heart disease (CHD) remain major causes of morbidity and mortality. Furthermore, psychological distress, itself, appears to increase the risk of CHD. However, the biological mechanism(s) through which psychological distress and CHD are related remain poorly understood. Recent evidence implicates deficient dietary consumption of fish oil (supplying omega-3 fatty acids) in both psychological distress and CHD. The proposed research would utilize structural equation modeling to test a hypothesized model positing that psychological distress and CHD share a causal factor - dietary omega-3 fatty acid deficiency - in which chronic, systemic inflammation serves as the mediating variable. Subjects will be 300 healthy community volunteers; already participating in a funded investigation (HL40962). The requested grant would: a) support additional assays of phospholipid fatty acid composition, interleukin-6 and C-reactive protein made possible through a new collaboration between the principal investigator and Dr. Jeffrey Yao, and b) support biostatistical analysis using structural equation modeling. Results of the study could redirect current conceptualizations of the relationship between psychological factors and CHD risk, and lead to randomized clinical trials testing new interventions.

描述（由申请人提供）：心理困扰，包括抑郁症和冠心病（CHD）仍然是发病和死亡的主要原因。此外，心理困扰本身似乎会增加患冠心病的风险。然而，心理困扰与冠心病相关的生物学机制仍知之甚少。最近的证据表明饮食中鱼油（提供 omega-3 脂肪酸）摄入不足会导致心理困扰和冠心病。拟议的研究将利用结构方程模型来测试一个假设模型，该模型假设心理困扰和冠心病有一个共同的因果因素——饮食中 omega-3 脂肪酸缺乏——其中慢性全身炎症作为中介变量。受试者为300名健康社区志愿者；已参与一项资助调查 (HL40962)。所申请的资助将：a) 支持通过首席研究员和 Jeffrey Yao 博士之间的新合作，对磷脂脂肪酸组成、白细胞介素 6 和 C 反应蛋白进行更多测定，b) 支持使用结构方程模型进行生物统计分析。该研究的结果可能会改变当前对心理因素与冠心病风险之间关系的概念，并导致随机临床试验测试新的干预措施。