EFFECTS OF OMEGA-3 FATTY ACIDS ON COGNITIVE PERFORMANCE

OMEGA-3 脂肪酸对认知能力的影响

基本信息

批准号：
8090503
负责人：
MATTHEW F MULDOON
金额：
$ 14.85万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8090503
关键词：
Adult Affect Age-Years American Apolipoprotein E Attention Award Blood Brain Cardiovascular Diseases Cardiovascular system Cell membrane Clinical Cognition Cognitive Communities Consumption Data Data Collection Dementia Development Diet Dietary intake Docosahexaenoic Acids Eating Education Eicosapentaenoic Acid Elderly Fatty Acids Fish Oils Fishes Gene Expression General Population Genotype Health Heart Diseases Human Impulsivity Incidence Individual Inflammation Intake Learning Link Malnutrition Measures Mediating Memory Mental Health Neuropsychological Tests Nutrient Omega-3 Fatty Acids Patients Performance Placebo Control Process Psyche structure Randomized Regulation Research Research Support Risk Short-Term Memory Signal Transduction Source Speed Supplementation Symptoms Testing Tissues Work cardiovascular disorder risk cognitive function executive function heart disease risk improved information processing middle age neuropsychological placebo controlled study programs research study secondary outcome treatment duration volunteer

项目摘要

DESCRIPTION (provided by applicant): The long-chain omega-3 fatty acids are essential nutrients found primarily in fish. Most Americans eat little fish and, therefore, may be at risk for health sequelae. Clinical trail evidence generally indicates beneficial effects of fish oil supplementation: a) on cardiovascular disease incidence in patients with heart disease and, b) in terms of symptom amelioration in psychiatric patient groups. However, the effects of supplementation in the general population are unknown. The applicant and his colleagues have recently received support to conduct a randomized and placebo-controlled clinical experiment in healthy, adult community volunteers to test the effects of fish oil supplementation on markers for cardiovascular disease risk, negative affect and impulsivity. New observational evidence now also links low dietary intake or tissue levels of omega-3 fatty acids to poor cognitive functioning or dementia. The objective of the proposed research is to examine in the context of the described study the putative cognitive effects of supplementation in healthy adults who habitually consume little or no fish. This new, secondary outcome would entail administration of a battery of neuropsychological tests assessing working and general memory, psychomotor speed, attention and executive function at baseline and after at the end of the treatment period. Any demonstrable improvements in cognitive performance with supplementation would indicate both that dietary deficiency negatively affects cognition and that such performance decrements are reversible in a practical manner through increased omega-3 fatty acid consumption. PUBLIC HEALTH RELEVANCE: The long-chain omega-3 fatty acids are essential nutrients that are highly concentrated in the brain yet Americans typically consume very little of these nutrients in their diets. Since some evidence links low intake with poor cognitive function, the planned research would test whether taking a supplement of omega-3 fatty acids improves mental speed, information processing, and memory.

描述（由申请人提供）：长链 omega-3 脂肪酸是主要存在于鱼类中的必需营养素。大多数美国人很少吃鱼，因此可能面临健康后遗症的风险。临床试验证据通常表明补充鱼油具有有益作用：a）对心脏病患者的心血管疾病发病率有好处，b）改善精神病患者群体的症状。然而，补充剂对普通人群的影响尚不清楚。申请人和他的同事最近获得了支持，在健康的成年社区志愿者中进行了一项随机和安慰剂对照的临床实验，以测试补充鱼油对心血管疾病风险、负面情绪和冲动标记的影响。现在新的观察证据也将低饮食摄入量或 omega-3 脂肪酸组织水平与认知功能不良或痴呆联系起来。拟议研究的目的是在所描述的研究背景下检查补充品对习惯很少或不吃鱼的健康成年人的认知影响。这一新的次要结果将需要进行一系列神经心理学测试，评估基线时和治疗期结束后的工作记忆和一般记忆、精神运动速度、注意力和执行功能。补充后认知能力的任何明显改善都表明饮食缺乏会对认知产生负面影响，而且这种能力下降实际上可以通过增加 omega-3 脂肪酸的消耗来逆转。公众健康相关性：长链 omega-3 脂肪酸是高度集中在大脑中的必需营养素，但美国人通常在饮食中摄入很少的这些营养素。由于一些证据表明摄入量低与认知功能较差有关，因此计划中的研究将测试补充 omega-3 脂肪酸是否可以提高思维速度、信息处理和记忆力。