ACCOMMODATING INTRAOCULAR LENSES

调节人工晶状体

• 批准号: 8173099
• 负责人: PAUL L KAUFMAN
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173099
• 关键词: Age; Animals; Appearance; Behavior; Cell Nucleus; Computer Retrieval of Information on Scientific Projects Database; Cornea; Data; Electrodes; Eye; Funding; Grant; Implant; Implanted Electrodes; Inflammation; Institution; Intraocular lens implant device; Keratoplasty; Macaca mulatta; Measurable; Monkeys; Operative Surgical Procedures; Positioning Attribute; Presbyopia; Procedures; Refractometry; Research; Research Personnel; Resources; Services; Shapes; Source; Specialist; Time; Transplantation; Ultrasonographic Biomicroscopy; United States National Institutes of Health; Vision; design; device Artificial lens; improved; lens; next generation; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the accommodative ability of intraocular lenses in rhesus monkeys following central stimulation. Electrodes were implanted into the Edinger Westphal nucleus of 6 rhesus monkeys so that accommodation could be stimulated centrally. The lens substance was replaced with artificial lenses designed by NuLens. The ability of these lenses to accommodate, change shape and position after central stimulation was determined using refractometry and ultrasound biomicroscopy. Accommodation of 8.0 diopters was induced during stimulation. Thus, these lenses have the potential to reverse the onset of presbyopia with age. It was determined that four animals with inflammation due to the intraocular lens surgery and severe corneal opacification required a corneal transplant in one or both eyes. Donor monkeys were located and corneal transplants were performed. Four months post transplant, slit lamp examination (SLE) revealed no rejection signs in two animals, but all corneas appeared slightly hazy. The haziness was more pronounced in the bilaterally treated monkeys. Dr. Neal Barney, one of our corneal specialists, examined these animals numerous times since their transplant procedure. He felt that these animals would maintain slightly hazy corneas, but had successfully tolerated the transplant procedure with an appearance and behavior consistent with improved vision. Since no measurable accommodation data was gathered in the two animals with more pronounced cornea haziness, those animals were euthanized. Three rhesus monkeys maintain accommodation from 3 to 8 diopters for at least eight months post IOL insertion. Experiments are conducted quarterly to document the NuLens IOL functionality. Potentially two additional rhesus monkeys will receive an electrode implant followed by the next generation NuLens IOL. This research used WNPRC Research Services.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：确定中央刺激后恒河猴中眼内镜头的可容纳能力。 将电极植入了6只恒河猴的Edinger Westphal核中，以便可以在中心刺激适应。 将镜头物质代替由努龙设计的人造镜头。 使用折射率和超声生物显微镜确定这些镜头可容纳，改变形状和位置的能力。 在刺激期间诱导了8.0局的容纳。 因此，这些镜片有可能随着年龄的增长而扭转长老会的发作。据确定，由于眼内晶状体手术和严重的角膜无情而引起炎症的四只动物需要一只或两只眼睛的角膜移植。位置并进行了角膜移植。移植后四个月，缝隙灯检查（SLE）显示两只动物没有拒绝迹象，但所有角膜似乎都略有朦胧。在双侧处理的猴子中，朦胧更为明显。我们的角膜专家之一尼尔·巴尼（Neal Barney）博士自移植手术以来就多次检查了这些动物。他认为这些动物会保持略带朦胧的角膜，但成功地忍受了移植程序，其外观和行为与改善的视力一致。 由于在具有更明显的角膜朦胧的两只动物中没有收集可衡量的住宿数据，因此这些动物被安乐死了。 IOL插入后至少八个月，三只恒河猴在3至8个二线剂中保持住宿。每季度进行实验以记录努伦族IOL功能。潜在的另外两个恒河猴将接收一个电极植入物，然后再获得下一代Nulens IOL。 这项研究使用了WNPRC研究服务。