Extralenticular Aspects of Accommodation and Presbyopia

调节和老花眼的晶状体外方面

基本信息

批准号：
9198869
负责人：
PAUL L KAUFMAN
金额：
$ 62.49万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-01-01 至 2019-12-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): We seek to continue and advance our group's study of human accommodative amplitude (the maximum ability of the eye to focus on near objects) and accommodative loss (presbyopia, literally "old eye") the most common ocular affliction in the world. Through our group's recent research in the monkey model, we have made the significant discovery of the existence of new extralenticular-zonular structures (PVZ INS-LE strands), which are linked to accommodation. In particular, we hypothesize that these structures may act as a strut to the posterior lens equator during accommodation and thereby facilitate accommodative lens thickening. Likewise, preliminary studies in the monkey eye suggest cistern-like structures in the vitreous, which we hypothesize play a role in fluid exchange between the anterior and posterior segments during accommodation. Despite these novel discoveries, it is clear that aspects of accommodation and the definitive mechanisms that result in presbyopia are yet to be fully determined and studied. Likewise, we hypothesize that age-related immobility of the ciliary muscle is due to posterior restriction. We postulate that, if cerain posterior restrictions are eliminated, mobility of the muscle can be restored and can facilitate th function of accommodating intraocular lenses (IOLs). The goals of our proposed research are: 1) To investigate and define the new players in the posterior restriction of the ciliary muscle, elucidation of which may be crucial in preserving forward ciliary body (FCB) movement and in enabling the function of the next-generation accommodating IOLs; 2) Determine the posterior extent of choroid/retina accommodative movement (i e., optic nerve region) with implications for accommodative mechanism and biomechanical models; 3) Define the role that the various intraocular structures (i.e., anterior hyaloid, vitreous zonule, vitreous cistern-like structure, PZ INS-LE strand, Hannover's Canal) play during accommodation and their change with age in the rhesus monkey (due to similarities to the human eye); and 4) To identify a biological target for human presbyopia therapy, albeit not necessarily a therapeutic surgical procedure for that target in the human eye. We believe the identification of, and proposed continued research of, these and associated structures will affect the understanding of how the eye accommodates earlier in life, and thereby change how we understand and treat presbyopia. The energy and excitement in our group is high, based upon our recent progress and the promises they hold for those with presbyopia.

描述（由申请人提供）：我们寻求继续并推进我们小组对人类调节幅度（眼睛聚焦近处物体的最大能力）和调节丧失（老花眼，字面意思是“老眼”）最常见的眼部疾病的研究通过我们课题组最近对猴子模型的研究，我们发现了新的晶状体外小带结构（PVZ INS-LE）的存在。特别是，我们认为这些结构在调节过程中可能充当后晶状体赤道的支柱，从而促进调节晶状体增厚。类似地，对猴眼的初步研究表明，在猴眼中存在类似水池的结构。我们首创的玻璃体在调节过程中前段和后段之间的液体交换中发挥着作用，尽管有这些新发现，但很明显，调节方面和导致老花眼的确定机制尚未完全确定和确定。同样，我们发现与年龄相关的睫状肌不动是由于后部限制造成的。我们假设，如果消除某些后部限制，肌肉的活动性可以恢复，并可以促进调节人工晶状体（IOL）的功能。我们提出的研究目标是：1）调查和定义睫状肌后部限制的新参与者，阐明其对于保持睫状体（FCB）向前运动至关重要。以及实现下一代可调节人工晶状体的功能； 2) 确定脉络膜/视网膜可调节运动（即视神经区域）的后部范围，这对可调节机制和生物力学模型有影响； 3) 定义人工晶状体的作用；各种眼内结构（即前玻璃体、玻璃体小带、玻璃体池样结构、PZ INS-LE链，汉诺威运河）在恒河猴的调节过程中玩耍及其随年龄的变化（由于与人眼的相似性）；4）确定人类老花眼治疗的生物目标，但不一定是针对该目标的治疗性外科手术我们相信，对这些及相关结构的识别和建议的持续研究将影响对眼睛在生命早期如何适应的理解，从而改变我们对老花眼的能量和兴奋的理解和治疗。根据我们最近的进展以及他们对老花眼患者的承诺，该群体的地位很高。