ACCOMMODATING INTRAOCULAR LENSES

调节人工晶状体

• 批准号: 8358209
• 负责人: PAUL L KAUFMAN
• 金额: $ 0.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358209
• 关键词: Age; Animals; Cell Nucleus; Cornea; Data; Electrodes; Eye; Funding; Grant; Implant; Implanted Electrodes; Inflammation; Intraocular lens implant device; Keratoplasty; Macaca mulatta; Monkeys; National Center for Research Resources; Operative Surgical Procedures; Pathology; Positioning Attribute; Presbyopia; Primates; Principal Investigator; Refractometry; Research; Research Infrastructure; Resources; Services; Shapes; Source; Ultrasonographic Biomicroscopy; United States National Institutes of Health; Wisconsin; cost; design; device Artificial lens; lens; next generation; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the accommodative ability of intraocular lenses in rhesus monkeys following central stimulation. PROGRESS: Electrodes were implanted into the Edinger Westphal nucleus of 6 rhesus monkeys so that accommodation could be stimulated centrally. The lens substance was replaced with artificial lenses designed by NuLens. The ability of these lenses to accommodate, change shape and position after central stimulation was determined using refractometry and ultrasound biomicroscopy. Accommodation of 8.0 diopters was induced during stimulation. Thus, these lenses have the potential to reverse the onset of presbyopia with age. It was determined that four animals with inflammation due to the intraocular lens surgery and severe corneal opacification required a corneal transplant in one or both eyes. Donor monkeys were located and corneal transplants were performed. Accommodation experiments were conducted. Once accommodation data could no longer be gathered, all four animals were euthanized. Two rhesus monkeys each maintain accommodation from 3 to 8 diopters in one eye. Experiments are conducted quarterly to document NuLens IOL functionality. Potentially two additional rhesus monkeys will receive an electrode implant followed by the next generation NuLens IOL. This research used WNPRC Animal and Pathology Services. PUBLICATIONS: None.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 目的：确定恒河猴中枢刺激后人工晶状体的调节能力。 进步： 将电极植入 6 只恒河猴的 Edinger Westphal 核中，以便集中刺激调节。 镜片物质被 NuLens 设计的人造镜片取代。 使用折射测量和超声生物显微镜确定这些晶状体在中枢刺激后适应、改变形状和位置的能力。在刺激期间诱导8.0屈光度的调节。 因此，这些镜片有可能逆转随着年龄增长而出现的老花眼。经确定，四只因人工晶状体手术而患有炎症和严重角膜混浊的动物需要一只或两只眼睛进行角膜移植。找到供体猴并进行角膜移植。进行了住宿实验。一旦无法再收集住宿数据，所有四只动物都被安乐死。 两只恒河猴每只一只眼睛的屈光度保持在 3 到 8 之间。每季度进行一次实验来记录 NuLens IOL 功能。 可能会有另外两只恒河猴接受电极植入，然后接受下一代 NuLens IOL。 这项研究使用了 WNPRC 动物和病理学服务。 出版物： 没有任何。